Comput Math Methods Med - Excitation-contraction coupling between human atrial myocytes with fibroblasts and stretch activated channel current: a simulation study.

Tópicos

{ model(2220) cell(1177) simul(1124) }
{ activ(1138) subject(705) human(624) }
{ signal(2180) analysi(812) frequenc(800) }
{ import(1318) role(1303) understand(862) }
{ model(3480) simul(1196) paramet(876) }
{ method(1557) propos(1049) approach(1037) }
{ data(1714) softwar(1251) tool(1186) }
{ studi(1410) differ(1259) use(1210) }
{ compound(1573) activ(1297) structur(1058) }
{ record(1888) medic(1808) patient(1693) }
{ state(1844) use(1261) util(961) }
{ method(1969) cluster(1462) data(1082) }
{ network(2748) neural(1063) input(814) }
{ take(945) account(800) differ(722) }
{ studi(2440) review(1878) systemat(933) }
{ problem(2511) optim(1539) algorithm(950) }
{ chang(1828) time(1643) increas(1301) }
{ clinic(1479) use(1117) guidelin(835) }
{ case(1353) use(1143) diagnosi(1136) }
{ perform(999) metric(946) measur(919) }
{ research(1085) discuss(1038) issu(1018) }
{ spatial(1525) area(1432) region(1030) }
{ gene(2352) biolog(1181) express(1162) }
{ first(2504) two(1366) second(1323) }
{ model(3404) distribut(989) bayesian(671) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ data(1737) use(1416) pattern(1282) }
{ inform(2794) health(2639) internet(1427) }
{ system(1976) rule(880) can(841) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
{ sequenc(1873) structur(1644) protein(1328) }
{ method(1219) similar(1157) match(930) }
{ featur(3375) classif(2383) classifi(1994) }
{ imag(2830) propos(1344) filter(1198) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ motion(1329) object(1292) video(1091) }
{ assess(1506) score(1403) qualiti(1306) }
{ treatment(1704) effect(941) patient(846) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ framework(1458) process(801) describ(734) }
{ error(1145) method(1030) estim(1020) }
{ learn(2355) train(1041) set(1003) }
{ concept(1167) ontolog(924) domain(897) }
{ algorithm(1844) comput(1787) effici(935) }
{ extract(1171) text(1153) clinic(932) }
{ design(1359) user(1324) use(1319) }
{ control(1307) perform(991) simul(935) }
{ care(1570) inform(1187) nurs(1089) }
{ general(901) number(790) one(736) }
{ method(984) reconstruct(947) comput(926) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ risk(3053) factor(974) diseas(938) }
{ system(1050) medic(1026) inform(1018) }
{ model(2341) predict(2261) use(1141) }
{ visual(1396) interact(850) tool(830) }
{ perform(1367) use(1326) method(1137) }
{ studi(1119) effect(1106) posit(819) }
{ blood(1257) pressur(1144) flow(957) }
{ health(3367) inform(1360) care(1135) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
{ data(3008) multipl(1320) sourc(1022) }
{ intervent(3218) particip(2042) group(1664) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ analysi(2126) use(1163) compon(1037) }
{ health(1844) social(1437) communiti(874) }
{ structur(1116) can(940) graph(676) }
{ high(1669) rate(1365) level(1280) }
{ cancer(2502) breast(956) screen(824) }
{ use(976) code(926) identifi(902) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ result(1111) use(1088) new(759) }
{ implement(1333) system(1263) develop(1122) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ decis(3086) make(1611) patient(1517) }
{ process(1125) use(805) approach(778) }
{ activ(1452) weight(1219) physic(1104) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

Myocytes have been regarded as the main objectives in most cardiac modeling studies and attracted a lot of attention. Connective tissue cells, such as fibroblasts (Fbs), also play crucial role in cardiac function. This study proposed an integrated myocyte-I sac-Fb electromechanical model to investigate the effect of Fbs and stretch activated ion channel current (I sac) on cardiac electrical excitation conduction and mechanical contraction. At the cellular level, an active Fb model was coupled with a human atrial myocyte electrophysiological model (including I sac) and a mechanical model. At the tissue level, electrical excitation conduction was coupled with an elastic mechanical model, in which finite difference method (FDM) was used to solve the electrical excitation equations, while finite element method (FEM) was used for the mechanics equations. The simulation results showed that Fbs and I sac coupling caused diverse effects on action potential morphology during repolarization, depolarized the resting membrane potential of the human atrial myocyte, slowed down wave propagation, and decreased strains in fibrotic tissue. This preliminary simulation study indicates that Fbs and I sac have important implications for modulating cardiac electromechanical behavior and should be considered in future cardiac modeling studies.

Resumo Limpo

myocyt regard main object cardiac model studi attract lot attent connect tissu cell fibroblast fbs also play crucial role cardiac function studi propos integr myocytei sacfb electromechan model investig effect fbs stretch activ ion channel current sac cardiac electr excit conduct mechan contract cellular level activ fb model coupl human atrial myocyt electrophysiolog model includ sac mechan model tissu level electr excit conduct coupl elast mechan model finit differ method fdm use solv electr excit equat finit element method fem use mechan equat simul result show fbs sac coupl caus divers effect action potenti morpholog repolar depolar rest membran potenti human atrial myocyt slow wave propag decreas strain fibrot tissu preliminari simul studi indic fbs sac import implic modul cardiac electromechan behavior consid futur cardiac model studi

Resumos Similares

Med Biol Eng Comput - Influence of heterogeneous and anisotropic tissue conductivity on electric field distribution in deep brain stimulation. ( 0,907844554578004 )
Med Biol Eng Comput - Extracting the parameters of the double-dispersion Cole bioimpedance model from magnitude response measurements. ( 0,879776324788333 )
Comput. Biol. Med. - Simulating a dual-array electrode configuration to investigate the influence of skeletal muscle fatigue following functional electrical stimulation. ( 0,869886143785708 )
J Med Syst - Functional and mechanical evaluation of nerve stretch injury. ( 0,858352408043234 )
Med Biol Eng Comput - Improved numerical approach for electrical modeling of biological cell clusters. ( 0,856533497963041 )
Comput Math Methods Med - The influence of the specimen shape and loading conditions on the parameter identification of a viscoelastic brain model. ( 0,829454297088249 )
Comput Methods Programs Biomed - Development/global validation of a 6-month-old pediatric head finite element model and application in investigation of drop-induced infant head injury. ( 0,826655895414673 )
Med Biol Eng Comput - Effect of heterogeneities in the cellular microstructure on propagation of the cardiac action potential. ( 0,825743829825561 )
Comput. Biol. Med. - Simulation of the microscopic process during initiation of stent thrombosis. ( 0,824537271742085 )
Med Biol Eng Comput - The influence of skeletal muscle anisotropy on electroporation: in vivo study and numerical modeling. ( 0,816374657890261 )
Med Biol Eng Comput - Finite element modeling of mitral leaflet tissue using a layered shell approximation. ( 0,810857950199735 )
Comput. Biol. Med. - Estimation of saline-mixed tissue conductivity and ablation lesion size. ( 0,803386145495074 )
Comput Math Methods Med - Three-dimensional lower extremity joint loading in a carved ski and snowboard turn: a pilot study. ( 0,792125055209421 )
Comput. Biol. Med. - Effects of degenerated intervertebral discs on intersegmental rotations, intradiscal pressures, and facet joint forces of the whole lumbar spine. ( 0,788470496439198 )
Med Biol Eng Comput - Deformation and pressure propagation in deep tissue during mechanical painful pressure stimulation. ( 0,785082504736706 )
Comput Math Methods Med - Spreading out muscle mass within a Hill-type model: a computer simulation study. ( 0,781670443681566 )
Med Biol Eng Comput - Comparison of spinal cord stimulation profiles from intra- and extradural electrode arrangements by finite element modelling. ( 0,776732171288539 )
Int J Med Robot - Comparison of the biomechanical effects of pertrochanteric fixator and dynamic hip screw on an intertrochanteric femoral fracture using the finite element method. ( 0,76444093134425 )
Int J Comput Assist Radiol Surg - Multi-scale model for investigating the electrical properties and mechanical properties of liver tissue undergoing ablation. ( 0,763742677390489 )
Med Biol Eng Comput - Towards the development of a novel experimental shoulder simulator with rotating scapula and individually controlled muscle forces simulating the rotator cuff. ( 0,759927149631645 )
Comput Math Methods Med - Application of computational lower extremity model to investigate different muscle activities and joint force patterns in knee osteoarthritis patients during walking. ( 0,757905985319908 )
Comput Math Methods Med - The effect of inhibitory neuron on the evolution model of higher-order coupling neural oscillator population. ( 0,757322952268024 )
Comput Math Methods Med - Modeling the chemoelectromechanical behavior of skeletal muscle using the parallel open-source software library OpenCMISS. ( 0,756313790850803 )
Med Biol Eng Comput - Sensitivity studies of pediatric material properties on juvenile lumbar spine responses using finite element analysis. ( 0,753970820218417 )
Med Biol Eng Comput - Empirical quantification of internal and external rotation muscular co-activation ratios in healthy shoulders. ( 0,750282942714797 )
Comput Math Methods Med - Morphological measurement of living cells in methanol with digital holographic microscopy. ( 0,750126123528958 )
Med Biol Eng Comput - Influence of ischemic core muscle fibers on surface depolarization potentials in superfused cardiac tissue preparations: a simulation study. ( 0,747549127473624 )
Med Biol Eng Comput - A three-dimensional finite element model of the cervical spine: an investigation of whiplash injury. ( 0,739430264736465 )
Comput Methods Programs Biomed - A phenomenological mathematical model of the articular cartilage damage. ( 0,738587669113453 )
Med Biol Eng Comput - Transmembrane potential generated by a magnetically induced transverse electric field in a cylindrical axonal model. ( 0,735252894511849 )
Comput Math Methods Med - MRI-based multiscale model for electromagnetic analysis in the human head with implanted DBS. ( 0,734652322938987 )
Comput. Biol. Med. - Computational studies on strain transmission from a collagen gel construct to a cell and its internal cytoskeletal filaments. ( 0,734564410221552 )
Comput Math Methods Med - A finite element study of micropipette aspiration of single cells: effect of compressibility. ( 0,734466733869834 )
Comput Methods Programs Biomed - Experiment and hydro-mechanical coupling simulation study on the human periodontal ligament. ( 0,734104302397814 )
Med Biol Eng Comput - Effects of skin wrinkles, age and wetness on mechanical loads in the stratum corneum as related to skin lesions. ( 0,731461736834115 )
Med Biol Eng Comput - Where does transcranial magnetic stimulation (TMS) stimulate? Modelling of induced field maps for some common cortical and cerebellar targets. ( 0,729360043954222 )
Comput Math Methods Med - Superficial collagen fibril modulus and pericellular fixed charge density modulate chondrocyte volumetric behaviour in early osteoarthritis. ( 0,728622945365066 )
Int J Med Robot - A physics-based algorithm for real-time simulation of electrosurgery procedures in minimally invasive surgery. ( 0,727135513677228 )
Med Biol Eng Comput - Temporal evolution of skeletal regenerated tissue: what can mechanical investigation add to biological? ( 0,723327688143096 )
Comput Methods Programs Biomed - Growth plate stress distribution implications during bone development: a simple framework computational approach. ( 0,721025408626894 )
Med Biol Eng Comput - Mathematical modeling of stem cell proliferation. ( 0,72064536402487 )
Wiley Interdiscip Rev Syst Biol Med - A systems biology approach to synovial joint lubrication in health, injury, and disease. ( 0,720281053367854 )
Neural Comput - Deficient GABAergic gliotransmission may cause broader sensory tuning in schizophrenia. ( 0,719275131436428 )
Comput Math Methods Med - A review of the combination of experimental measurements and fibril-reinforced modeling for investigation of articular cartilage and chondrocyte response to loading. ( 0,718294384781346 )
Comput Math Methods Med - An approach for simulation of the muscle force modeling it by summation of motor unit contraction forces. ( 0,717905867191685 )
Med Biol Eng Comput - Change of mechanical vertebrae properties due to progressive osteoporosis: combined biomechanical and finite-element analysis within a rat model. ( 0,717580440080099 )
Med Biol Eng Comput - Multi-scale study of nanoparticle transport and deposition in tissues during an injection process. ( 0,717534937215332 )
J Clin Monit Comput - Improved spatial resolution and electrogram wave direction independence with the use of an orthogonal electrode configuration. ( 0,714969110896425 )
Med Biol Eng Comput - Clinically oriented real-time monitoring of the individual's risk for deep tissue injury. ( 0,714968542076208 )
Med Biol Eng Comput - Mechanical and microarchitectural analyses of cancellous bone through experiment and computer simulation. ( 0,712456566682234 )
Comput Math Methods Med - Recent advances in computational mechanics of the human knee joint. ( 0,71015596018497 )
Med Biol Eng Comput - Characterization of cellular elastic modulus using structure based double layer model. ( 0,708173533047892 )
Med Biol Eng Comput - Biomechanical characterisation of fresh and cadaverous human small intestine: applications for abdominal trauma. ( 0,705349719663314 )
Comput Math Methods Med - Noninvasive measurement of conductivity anisotropy at larmor frequency using MRI. ( 0,70532590441332 )
J Clin Monit Comput - Spinal cord injury from electrocautery: observations in a porcine model using electromyography and motor evoked potentials. ( 0,70404718708464 )
Med Biol Eng Comput - Estimating nerve excitation thresholds to cutaneous electrical stimulation by finite element modeling combined with a stochastic branching nerve fiber model. ( 0,702434850228183 )
Comput. Biol. Med. - Biological-data-based finite-element stress analysis of mandibular bone with implant-supported overdenture. ( 0,700688588678566 )
Med Biol Eng Comput - A new method to include the gravitational forces in a finite element model of the scoliotic spine. ( 0,69976664823465 )
Med Biol Eng Comput - Flexible and stretchable micro-electrodes for in vitro and in vivo neural interfaces. ( 0,699690449240273 )
Comput Math Methods Med - Optimisation of ionic models to fit tissue action potentials: application to 3D atrial modelling. ( 0,698489049565164 )
Med Biol Eng Comput - Sensitivity of patient-specific vertebral finite element model from low dose imaging to material properties and loading conditions. ( 0,698182937318036 )
Med Biol Eng Comput - Biomechanical analysis of the effects of medial meniscectomy on degenerative osteoarthritis. ( 0,696347132441184 )
Comput Methods Programs Biomed - A patient specific electro-mechanical model of the heart. ( 0,695228923532416 )
Int J Comput Assist Radiol Surg - Surgical stent planning: simulation parameter study for models based on DICOM standards. ( 0,695062311688724 )
Comput. Aided Surg. - A biomechanical study regarding the effect of tissue harvesting from the thorax on its movement during inspiration. ( 0,692134876475689 )
Comput Math Methods Med - Numerical simulations of MREIT conductivity imaging for brain tumor detection. ( 0,690818345332603 )
Comput. Biol. Med. - Protein transport in the connecting cilium of a photoreceptor cell: modeling the effects of bidirectional protein transitions between the diffusion-driven and motor-driven kinetic states. ( 0,690314914430352 )
Med Biol Eng Comput - In-silico modeling of atrial repolarization in normal and atrial fibrillation remodeled state. ( 0,689850432049682 )
J Med Syst - Post-operative assessment of an implant fixation in anterior cruciate ligament reconstructive surgery. ( 0,688583488038138 )
J Clin Monit Comput - Digital resolution enhancement of intracardiac excitation maps during atrial fibrillation. ( 0,688011492436098 )
Med Biol Eng Comput - Intraoperative forces and moments analysis on patient head clamp during awake brain surgery. ( 0,686590993251849 )
Med Biol Eng Comput - Modeling and experimental methods to predict oxygen distribution in bone defects following cell transplantation. ( 0,686374192661075 )
Comput Methods Programs Biomed - Performance optimization of current focusing and virtual electrode strategies in retinal implants. ( 0,68505682969144 )
Med Biol Eng Comput - Validation efforts and flexibilities of an eight-year-old human juvenile lumbar spine using a three-dimensional finite element model. ( 0,68345207266535 )
Neural Comput - Ambient GABA responsible for age-related changes in multistable perception. ( 0,681174481531349 )
Med Biol Eng Comput - Microfabricated substrates as a tool to study cell mechanotransduction. ( 0,680507136842507 )
Comput Methods Programs Biomed - Subject-specific finite element simulation of the human femur considering inhomogeneous material properties: a straightforward method and convergence study. ( 0,680102890954075 )
Comput Biol Chem - Macroscopic simulations of microtubule dynamics predict two steady-state processes governing array morphology. ( 0,680009482420563 )
Med Biol Eng Comput - Calibration of the mechanical properties in a finite element model of a lumbar vertebra under dynamic compression up to failure. ( 0,679754175678912 )
Med Biol Eng Comput - The remodeling of alveolar bone supporting the mandibular first molar with different levels of periodontal attachment. ( 0,678445901263166 )
Med Biol Eng Comput - The effects of femoral neck cut, cable tension, and muscles forces on the greater trochanter fixation. ( 0,678150445891564 )
Int J Comput Assist Radiol Surg - Bivariate optimization of orthodontic mini-implant thread height and pitch. ( 0,678142397084073 )
Comput Math Methods Med - Contribution to the determination of in vivo mechanical characteristics of human skin by indentation test. ( 0,676806969067308 )
Comput. Biol. Med. - Muscle activity detection in electromyograms recorded during periodic movements. ( 0,676646888506968 )
Comput Methods Programs Biomed - Anthropometric dependence of the response of a thorax FE model under high speed loading: validation and real world accident replication. ( 0,673948012913049 )
Med Biol Eng Comput - 3D finite element analysis on esthetic indirect dental restorations under thermal and mechanical loading. ( 0,673932135550912 )
Med Biol Eng Comput - Strain rate-dependent viscohyperelastic constitutive modeling of bovine liver tissue. ( 0,673830939596265 )
Med Biol Eng Comput - The potential of pulsed low intensity ultrasound to stimulate chondrocytes matrix synthesis in agarose and monolayer cultures. ( 0,672444204416761 )
Comput. Biol. Med. - Biomechanical simulation of various surface roughnesses and geometric designs on an immediately loaded dental implant. ( 0,672304754839196 )
Med Biol Eng Comput - Finite element analysis of the influence of loading rate on a model of the full lumbar spine under dynamic loading conditions. ( 0,671318934098762 )
Med Biol Eng Comput - Continuous flow left ventricular pump support and its effect on regional left ventricular wall stress: finite element analysis study. ( 0,669988358533199 )
Wiley Interdiscip Rev Syst Biol Med - Ischemic kidney injury and mechanisms of tissue repair. ( 0,669804096879285 )
Comput Methods Programs Biomed - 2D and 3D finite element analysis of central incisor generated by computerized tomography. ( 0,668804422502619 )
Comput. Biol. Med. - Design, analysis and verification of a knee joint oncological prosthesis finite element model. ( 0,668611305111801 )
Brief. Bioinformatics - Computational systems biology and in silico modeling of the human microbiome. ( 0,667064941864375 )
Med Biol Eng Comput - Modeling and analysis of coagulated liver tissue and its interaction with a scalpel blade. ( 0,666817035572863 )
Comput. Biol. Med. - Modeling skin thermal pain sensation: Role of non-Fourier thermal behavior in transduction process of nociceptor. ( 0,663915459973513 )
Int J Neural Syst - A new linear muscle fiber model for neural control of saccades. ( 0,663414039029885 )
Med Biol Eng Comput - Biomechanical analysis of traumatic mesenteric avulsion. ( 0,662446178434415 )
Comput Math Methods Med - Fluid structural analysis of human cerebral aneurysm using their own wall mechanical properties. ( 0,661727605060664 )