Comput Math Methods Med - Excitation-contraction coupling between human atrial myocytes with fibroblasts and stretch activated channel current: a simulation study.


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Myocytes have been regarded as the main objectives in most cardiac modeling studies and attracted a lot of attention. Connective tissue cells, such as fibroblasts (Fbs), also play crucial role in cardiac function. This study proposed an integrated myocyte-I sac-Fb electromechanical model to investigate the effect of Fbs and stretch activated ion channel current (I sac) on cardiac electrical excitation conduction and mechanical contraction. At the cellular level, an active Fb model was coupled with a human atrial myocyte electrophysiological model (including I sac) and a mechanical model. At the tissue level, electrical excitation conduction was coupled with an elastic mechanical model, in which finite difference method (FDM) was used to solve the electrical excitation equations, while finite element method (FEM) was used for the mechanics equations. The simulation results showed that Fbs and I sac coupling caused diverse effects on action potential morphology during repolarization, depolarized the resting membrane potential of the human atrial myocyte, slowed down wave propagation, and decreased strains in fibrotic tissue. This preliminary simulation study indicates that Fbs and I sac have important implications for modulating cardiac electromechanical behavior and should be considered in future cardiac modeling studies.

Resumo Limpo

myocyt regard main object cardiac model studi attract lot attent connect tissu cell fibroblast fbs also play crucial role cardiac function studi propos integr myocytei sacfb electromechan model investig effect fbs stretch activ ion channel current sac cardiac electr excit conduct mechan contract cellular level activ fb model coupl human atrial myocyt electrophysiolog model includ sac mechan model tissu level electr excit conduct coupl elast mechan model finit differ method fdm use solv electr excit equat finit element method fem use mechan equat simul result show fbs sac coupl caus divers effect action potenti morpholog repolar depolar rest membran potenti human atrial myocyt slow wave propag decreas strain fibrot tissu preliminari simul studi indic fbs sac import implic modul cardiac electromechan behavior consid futur cardiac model studi

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