Comput Math Methods Med - Segmentation of the striatum from MR brain images to calculate the 99mTc-TRODAT-1 binding ratio in SPECT images.

Tópicos

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Resumo

Quantification of regional (99m)Tc-TRODAT-1 binding ratio in the striatum regions in SPECT images is essential for differential diagnosis between Alzheimer's and Parkinson's diseases. Defining the region of the striatum in the SPECT image is the first step toward success in the quantification of the TRODAT-1 binding ratio. However, because SPECT images reveal insufficient information regarding the anatomical structure of the brain, correct delineation of the striatum directly from the SPECT image is almost impossible. We present a method integrating the active contour model and the hybrid registration technique to extract regions from MR T1-weighted images and map them into the corresponding SPECT images. Results from three normal subjects suggest that the segmentation accuracy using the proposed method was compatible with the expert decision but has a higher efficiency and reproducibility than manual delineation. The binding ratio derived by this method correlated well (R (2)=0.76) with those values calculated by commercial software, suggesting the feasibility of the proposed method.

Resumo Limpo

quantif region mtctrodat bind ratio striatum region spect imag essenti differenti diagnosi alzheim parkinson diseas defin region striatum spect imag first step toward success quantif trodat bind ratio howev spect imag reveal insuffici inform regard anatom structur brain correct delin striatum direct spect imag almost imposs present method integr activ contour model hybrid registr techniqu extract region mr tweight imag map correspond spect imag result three normal subject suggest segment accuraci use propos method compat expert decis higher effici reproduc manual delin bind ratio deriv method correl well r valu calcul commerci softwar suggest feasibl propos method

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