Comput Math Methods Med - Investigation of attenuation correction for small-animal single photon emission computed tomography.

Tópicos

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Resumo

The quantitative accuracy of SPECT is limited by photon attenuation and scatter effect when photons interact with atoms. In this study, we developed a new attenuation correction (AC) method, CT-based mean attenuation correction (CTMAC) method, and compared it with various methods that were often used currently to assess the AC phenomenon by using the small-animal SPECT/CT data that were acquired from various physical phantoms and a rat. The physical phantoms and an SD rat, which were injected with (99m)Tc, were scanned by a parallel-hole small-animal SPECT, and then they were imaged by the 80kVp micro-CT. Scatter was estimated and corrected by the triple-energy window (TEW) method. Absolute quantification was derived from a known activity point source scan. In the physical-phantom studies, we compared the images with original, scatter correction (SC) only, and the scatter-corrected images with AC performed by using Chang's method, CT-based attenuation correction (CTAC), CT-based iterative attenuation compensation during reconstruction (CTIACR), and the CTMAC. From the correction results, we find out that the errors of the previous six configurations are mostly quite similar. The CTMAC needs the shortest correction time while obtaining good AC results.

Resumo Limpo

quantit accuraci spect limit photon attenu scatter effect photon interact atom studi develop new attenu correct ac method ctbase mean attenu correct ctmac method compar various method often use current assess ac phenomenon use smallanim spectct data acquir various physic phantom rat physic phantom sd rat inject mtc scan parallelhol smallanim spect imag kvp microct scatter estim correct tripleenergi window tew method absolut quantif deriv known activ point sourc scan physicalphantom studi compar imag origin scatter correct sc scattercorrect imag ac perform use chang method ctbase attenu correct ctac ctbase iter attenu compens reconstruct ctiacr ctmac correct result find error previous six configur most quit similar ctmac need shortest correct time obtain good ac result

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