Comput Math Methods Med - A time-varying seasonal autoregressive model-based prediction of respiratory motion for tumor following radiotherapy.

Tópicos

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Resumo

To achieve a better therapeutic effect and suppress side effects for lung cancer treatments, latency involved in current radiotherapy devices is aimed to be compensated for improving accuracy of continuous (not gating) irradiation to a respiratory moving tumor. A novel prediction method of lung tumor motion is developed for compensating the latency. An essential core of the method is to extract information valuable for the prediction, that is, the periodic nature inherent in respiratory motion. A seasonal autoregressive model useful to represent periodic motion has been extended to take into account the fluctuation of periodic nature in respiratory motion. The extended model estimates the fluctuation by using a correlation-based analysis for adaptation. The prediction performance of the proposed method was evaluated by using data sets of actual tumor motion and compared with those of the state-of-the-art methods. The proposed method demonstrated a high performance within submillimeter accuracy. That is, the average error of 1.0s ahead predictions was 0.931 ? 0.055mm. The accuracy achieved by the proposed method was the best among those by the others. The results suggest that the method can compensate the latency with sufficient accuracy for clinical use and contribute to improve the irradiation accuracy to the moving tumor.

Resumo Limpo

achiev better therapeut effect suppress side effect lung cancer treatment latenc involv current radiotherapi devic aim compens improv accuraci continu gate irradi respiratori move tumor novel predict method lung tumor motion develop compens latenc essenti core method extract inform valuabl predict period natur inher respiratori motion season autoregress model use repres period motion extend take account fluctuat period natur respiratori motion extend model estim fluctuat use correlationbas analysi adapt predict perform propos method evalu use data set actual tumor motion compar stateoftheart method propos method demonstr high perform within submillimet accuraci averag error s ahead predict mm accuraci achiev propos method best among other result suggest method can compens latenc suffici accuraci clinic use contribut improv irradi accuraci move tumor

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