Comput Math Methods Med - Effective admittivity of biological tissues as a coefficient of elliptic PDE.

Tópicos

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Resumo

The electrical properties of biological tissues can be described by a complex tensor comprising a simple expression of the effective admittivity. The effective admittivities of biological tissues depend on scale, applied frequency, proportions of extra- and intracellular fluids, and membrane structures. The effective admittivity spectra of biological tissue can be used as a means of characterizing tissue structural information relating to the biological cell suspensions, and therefore measuring the frequency-dependent effective conductivity is important for understanding tissue's physiological conditions and structure. Although the concept of effective admittivity has been used widely, it seems that its precise definition has been overlooked. We consider how we can determine the effective admittivity for a cube-shaped object with several different biologically relevant compositions. These precise definitions of effective admittivity may suggest the ways of measuring it from boundary current and voltage data. As in the homogenization theory, the effective admittivity can be computed from pointwise admittivity by solving Maxwell equations. We compute the effective admittivity of simple models as a function of frequency to obtain Maxwell-Wagner interface effects and Debye relaxation starting from mathematical formulations. Finally, layer potentials are used to obtain the Maxwell-Wagner-Fricke expression for a dilute suspension of ellipses and membrane-covered spheres.

Resumo Limpo

electr properti biolog tissu can describ complex tensor compris simpl express effect admitt effect admitt biolog tissu depend scale appli frequenc proport extra intracellular fluid membran structur effect admitt spectra biolog tissu can use mean character tissu structur inform relat biolog cell suspens therefor measur frequencydepend effect conduct import understand tissu physiolog condit structur although concept effect admitt use wide seem precis definit overlook consid can determin effect admitt cubeshap object sever differ biolog relev composit precis definit effect admitt may suggest way measur boundari current voltag data homogen theori effect admitt can comput pointwis admitt solv maxwel equat comput effect admitt simpl model function frequenc obtain maxwellwagn interfac effect deby relax start mathemat formul final layer potenti use obtain maxwellwagnerfrick express dilut suspens ellips membranecov sphere

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