Comput Math Methods Med - A review of the combination of experimental measurements and fibril-reinforced modeling for investigation of articular cartilage and chondrocyte response to loading.

Tópicos

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Resumo

The function of articular cartilage depends on its structure and composition, sensitively impaired in disease (e.g. osteoarthritis, OA). Responses of chondrocytes to tissue loading are modulated by the structure. Altered cell responses as an effect of OA may regulate cartilage mechanotransduction and cell biosynthesis. To be able to evaluate cell responses and factors affecting the onset and progression of OA, local tissue and cell stresses and strains in cartilage need to be characterized. This is extremely challenging with the presently available experimental techniques and therefore computational modeling is required. Modern models of articular cartilage are inhomogeneous and anisotropic, and they include many aspects of the real tissue structure and composition. In this paper, we provide an overview of the computational applications that have been developed for modeling the mechanics of articular cartilage at the tissue and cellular level. We concentrate on the use of fibril-reinforced models of cartilage. Furthermore, we introduce practical considerations for modeling applications, including also experimental tests that can be combined with the modeling approach. At the end, we discuss the prospects for patient-specific models when aiming to use finite element modeling analysis and evaluation of articular cartilage function, cellular responses, failure points, OA progression, and rehabilitation.

Resumo Limpo

function articular cartilag depend structur composit sensit impair diseas eg osteoarthr oa respons chondrocyt tissu load modul structur alter cell respons effect oa may regul cartilag mechanotransduct cell biosynthesi abl evalu cell respons factor affect onset progress oa local tissu cell stress strain cartilag need character extrem challeng present avail experiment techniqu therefor comput model requir modern model articular cartilag inhomogen anisotrop includ mani aspect real tissu structur composit paper provid overview comput applic develop model mechan articular cartilag tissu cellular level concentr use fibrilreinforc model cartilag furthermor introduc practic consider model applic includ also experiment test can combin model approach end discuss prospect patientspecif model aim use finit element model analysi evalu articular cartilag function cellular respons failur point oa progress rehabilit

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