Comput Math Methods Med - Novel application of a multiscale entropy index as a sensitive tool for detecting subtle vascular abnormalities in the aged and diabetic.

Tópicos

{ signal(2180) analysi(812) frequenc(800) }
{ patient(2315) diseas(1263) diabet(1191) }
{ detect(2391) sensit(1101) algorithm(908) }
{ blood(1257) pressur(1144) flow(957) }
{ decis(3086) make(1611) patient(1517) }
{ activ(1452) weight(1219) physic(1104) }
{ studi(1410) differ(1259) use(1210) }
{ age(1611) year(1155) adult(843) }
{ group(2977) signific(1463) compar(1072) }
{ activ(1138) subject(705) human(624) }
{ can(981) present(881) function(850) }
{ studi(1119) effect(1106) posit(819) }
{ imag(1947) propos(1133) code(1026) }
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{ imag(1057) registr(996) error(939) }
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{ treatment(1704) effect(941) patient(846) }
{ data(1714) softwar(1251) tool(1186) }
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Resumo

Although previous studies have shown the successful use of pressure-induced reactive hyperemia as a tool for the assessment of endothelial function, its sensitivity remains questionable. This study aims to investigate the feasibility and sensitivity of a novel multiscale entropy index (MEI) in detecting subtle vascular abnormalities in healthy and diabetic subjects. Basic anthropometric and hemodynamic parameters, serum lipid profiles, and glycosylated hemoglobin levels were recorded. Arterial pulse wave signals were acquired from the wrist with an air pressure sensing system (APSS), followed by MEI and dilatation index (DI) analyses. MEI succeeded in detecting significant differences among the four groups of subjects: healthy young individuals, healthy middle-aged or elderly individuals, well-controlled diabetic individuals, and poorly controlled diabetic individuals. A reduction in multiscale entropy reflected age- and diabetes-related vascular changes and may serve as a more sensitive indicator of subtle vascular abnormalities compared with DI in the setting of diabetes.

Resumo Limpo

although previous studi shown success use pressureinduc reactiv hyperemia tool assess endotheli function sensit remain question studi aim investig feasibl sensit novel multiscal entropi index mei detect subtl vascular abnorm healthi diabet subject basic anthropometr hemodynam paramet serum lipid profil glycosyl hemoglobin level record arteri puls wave signal acquir wrist air pressur sens system apss follow mei dilat index di analys mei succeed detect signific differ among four group subject healthi young individu healthi middleag elder individu wellcontrol diabet individu poor control diabet individu reduct multiscal entropi reflect age diabetesrel vascular chang may serv sensit indic subtl vascular abnorm compar di set diabet

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