Comput Math Methods Med - Molecular signature of cancer at gene level or pathway level? Case studies of colorectal cancer and prostate cancer microarray data.

Tópicos

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Resumo

With recent advances in microarray technology, there has been a flourish in genome-scale identification of molecular signatures for cancer. However, the differentially expressed genes obtained by different laboratories are highly divergent. The present discrepancy at gene level indicates a need for a novel strategy to obtain more robust signatures for cancer. In this paper we hypothesize that (1) the expression signatures of different cancer microarray datasets are more similar at pathway level than at gene level; (2) the comparability of the cancer molecular mechanisms of different individuals is related to their genetic similarities. In support of the hypotheses, we summarized theoretical and experimental evidences, and conducted case studies on colorectal and prostate cancer microarray datasets. Based on the above assumption, we propose that reliable cancer signatures should be investigated in the context of biological pathways, within a cohort of genetically homogeneous population. It is hoped that the hypotheses can guide future research in cancer mechanism and signature discovery.

Resumo Limpo

recent advanc microarray technolog flourish genomescal identif molecular signatur cancer howev differenti express gene obtain differ laboratori high diverg present discrep gene level indic need novel strategi obtain robust signatur cancer paper hypothes express signatur differ cancer microarray dataset similar pathway level gene level compar cancer molecular mechan differ individu relat genet similar support hypothes summar theoret experiment evid conduct case studi colorect prostat cancer microarray dataset base assumpt propos reliabl cancer signatur investig context biolog pathway within cohort genet homogen popul hope hypothes can guid futur research cancer mechan signatur discoveri

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