Comput Math Methods Med - Simulation of the Frank-Starling Law of the Heart.

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Resumo

We developed a lumped parameter, computer-based model of an equivalent electronic circuit for a one-atrium one-ventricle (frog) heart attached to a vascular circuit, to simulate a basic concept of cardiovascular physiology, the Frank-Starling Law of the Heart. A series of simulations was performed, to observe changes in cardiovascular variables (e.g., arterial pressure, ventricular volume, and valve flows) if either preload or afterload was increased. The simulated data agreed qualitatively, and quantitatively when experimental data are available, with data obtained on amphibian or on mammalian myocardium. In addition, the data obtained in these simulations improve our understanding of the mechanism(s) whereby the heart muscle adapts itself to increased distension (increased preload) or to impeded systolic contraction (increased afterload). The analysis of the measured valve flows suggests that the ventricle is a highly input sensitive pump because the input pressure determines the diastolic distension and, consequently, the force of ventricular systolic contraction. On the other hand, the ventricle is a relatively output insensitive pump. Therefore, not only atrium contraction, but also predominantly the preceding ventricular systolic contraction is the main mechanism of the subsequent diastolic ventricular filling. We conclude that the presented model enables the study of basic concepts of cardiovascular physiology.

Resumo Limpo

develop lump paramet computerbas model equival electron circuit oneatrium oneventricl frog heart attach vascular circuit simul basic concept cardiovascular physiolog frankstarl law heart seri simul perform observ chang cardiovascular variabl eg arteri pressur ventricular volum valv flow either preload afterload increas simul data agre qualit quantit experiment data avail data obtain amphibian mammalian myocardium addit data obtain simul improv understand mechan wherebi heart muscl adapt increas distens increas preload imped systol contract increas afterload analysi measur valv flow suggest ventricl high input sensit pump input pressur determin diastol distens consequ forc ventricular systol contract hand ventricl relat output insensit pump therefor atrium contract also predomin preced ventricular systol contract main mechan subsequ diastol ventricular fill conclud present model enabl studi basic concept cardiovascular physiolog

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