Comput Math Methods Med - Spreading out muscle mass within a Hill-type model: a computer simulation study.

Tópicos

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Resumo

It is state of the art that muscle contraction dynamics is adequately described by a hyperbolic relation between muscle force and contraction velocity (Hill relation), thereby neglecting muscle internal mass inertia (first-order dynamics). Accordingly, the vast majority of modelling approaches also neglect muscle internal inertia. Assuming that such first-order contraction dynamics yet interacts with muscle internal mass distribution, this study investigates two questions: (i) what is the time scale on which the muscle responds to a force step? (ii) How does this response scale with muscle design parameters? Thereto, we simulated accelerated contractions of alternating sequences of Hill-type contractile elements and point masses. We found that in a typical small muscle the force levels off after about 0.2ms, contraction velocity after about 0.5ms. In an upscaled version representing bigger mammals' muscles, the force levels off after about 20ms, and the theoretically expected maximum contraction velocity is not reached. We conclude (i) that it may be indispensable to introduce second-order contributions into muscle models to understand high-frequency muscle responses, particularly in bigger muscles. Additionally, (ii) constructing more elaborate measuring devices seems to be worthwhile to distinguish viscoelastic and inertia properties in rapid contractile responses of muscles.

Resumo Limpo

state art muscl contract dynam adequ describ hyperbol relat muscl forc contract veloc hill relat therebi neglect muscl intern mass inertia firstord dynam accord vast major model approach also neglect muscl intern inertia assum firstord contract dynam yet interact muscl intern mass distribut studi investig two question time scale muscl respond forc step ii respons scale muscl design paramet thereto simul acceler contract altern sequenc hilltyp contractil element point mass found typic small muscl forc level ms contract veloc ms upscal version repres bigger mammal muscl forc level ms theoret expect maximum contract veloc reach conclud may indispens introduc secondord contribut muscl model understand highfrequ muscl respons particular bigger muscl addit ii construct elabor measur devic seem worthwhil distinguish viscoelast inertia properti rapid contractil respons muscl

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