Comput Math Methods Med - Computational modeling of microabscess formation.

Tópicos

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Resumo

Bacterial infections can be of two types: acute or chronic. The chronic bacterial infections are characterized by being a large bacterial infection and/or an infection where the bacteria grows rapidly. In these cases, the immune response is not capable of completely eliminating the infection which may lead to the formation of a pattern known as microabscess (or abscess). The microabscess is characterized by an area comprising fluids, bacteria, immune cells (mainly neutrophils), and many types of dead cells. This distinct pattern of formation can only be numerically reproduced and studied by models that capture the spatiotemporal dynamics of the human immune system (HIS). In this context, our work aims to develop and implement an initial computational model to study the process of microabscess formation during a bacterial infection.

Resumo Limpo

bacteri infect can two type acut chronic chronic bacteri infect character larg bacteri infect andor infect bacteria grow rapid case immun respons capabl complet elimin infect may lead format pattern known microabscess abscess microabscess character area compris fluid bacteria immun cell main neutrophil mani type dead cell distinct pattern format can numer reproduc studi model captur spatiotempor dynam human immun system context work aim develop implement initi comput model studi process microabscess format bacteri infect

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