Comput Math Methods Med - Reliability of semiautomated computational methods for estimating tibiofemoral contact stress in the Multicenter Osteoarthritis Study.


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Recent findings suggest that contact stress is a potent predictor of subsequent symptomatic osteoarthritis development in the knee. However, much larger numbers of knees (likely on the order of hundreds, if not thousands) need to be reliably analyzed to achieve the statistical power necessary to clarify this relationship. This study assessed the reliability of new semiautomated computational methods for estimating contact stress in knees from large population-based cohorts. Ten knees of subjects from the Multicenter Osteoarthritis Study were included. Bone surfaces were manually segmented from sequential 1.0 Tesla magnetic resonance imaging slices by three individuals on two nonconsecutive days. Four individuals then registered the resulting bone surfaces to corresponding bone edges on weight-bearing radiographs, using a semi-automated algorithm. Discrete element analysis methods were used to estimate contact stress distributions for each knee. Segmentation and registration reliabilities (day-to-day and interrater) for peak and mean medial and lateral tibiofemoral contact stress were assessed with Shrout-Fleiss intraclass correlation coefficients (ICCs). The segmentation and registration steps of the modeling approach were found to have excellent day-to-day (ICC 0.93-0.99) and good inter-rater reliability (0.84-0.97). This approach for estimating compartment-specific tibiofemoral contact stress appears to be sufficiently reliable for use in large population-based cohorts.

Resumo Limpo

recent find suggest contact stress potent predictor subsequ symptomat osteoarthr develop knee howev much larger number knee like order hundr thousand need reliabl analyz achiev statist power necessari clarifi relationship studi assess reliabl new semiautom comput method estim contact stress knee larg populationbas cohort ten knee subject multicent osteoarthr studi includ bone surfac manual segment sequenti tesla magnet reson imag slice three individu two nonconsecut day four individu regist result bone surfac correspond bone edg weightbear radiograph use semiautom algorithm discret element analysi method use estim contact stress distribut knee segment registr reliabl daytoday interrat peak mean medial later tibiofemor contact stress assess shroutfleiss intraclass correl coeffici icc segment registr step model approach found excel daytoday icc good interrat reliabl approach estim compartmentspecif tibiofemor contact stress appear suffici reliabl use larg populationbas cohort

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