Comput Math Methods Med - Dynamics of high-risk nonvaccine human papillomavirus types after actual vaccination scheme.

Tópicos

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Resumo

Human papillomavirus (HPV) has been identified as the main etiological factor in the developing of cervical cancer (CC). This finding has propitiated the development of vaccines that help to prevent the HPVs 16 and 18 infection. Both genotypes are associated with 70% of CC worldwide. In the present study, we aimed to determine the emergence of high-risk nonvaccine HPV after actual vaccination scheme to estimate the impact of the current HPV vaccines. A SIR-type model was used to study the HPV dynamics after vaccination. According to the results, our model indicates that the application of the vaccine reduces infection by target or vaccine genotypes as expected. However, numerical simulations of the model suggest the presence of the phenomenon called vaccine-induced pathogen strain replacement. Here, we report the following replacement mechanism: if the effectiveness of cross-protective immunity is not larger than the effectiveness of the vaccine, then the high-risk nonvaccine genotypes emerge. In this scenario, further studies of infection dispersion by HPV are necessary to ascertain the real impact of the current vaccines, primarily because of the different high-risk HPV types that are found in CC.

Resumo Limpo

human papillomavirus hpv identifi main etiolog factor develop cervic cancer cc find propiti develop vaccin help prevent hpvs infect genotyp associ cc worldwid present studi aim determin emerg highrisk nonvaccin hpv actual vaccin scheme estim impact current hpv vaccin sirtyp model use studi hpv dynam vaccin accord result model indic applic vaccin reduc infect target vaccin genotyp expect howev numer simul model suggest presenc phenomenon call vaccineinduc pathogen strain replac report follow replac mechan effect crossprotect immun larger effect vaccin highrisk nonvaccin genotyp emerg scenario studi infect dispers hpv necessari ascertain real impact current vaccin primarili differ highrisk hpv type found cc

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