Comput Math Methods Med - Simulation of spread and control of lesions in brain.

Tópicos

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Resumo

A simulation model for the spread and control of lesions in the brain is constructed using a planar network (graph) representation for the central nervous system (CNS). The model is inspired by the lesion structures observed in the case of multiple sclerosis (MS), a chronic disease of the CNS. The initial lesion site is at the center of a unit square and spreads outwards based on the success rate in damaging edges (axons) of the network. The damaged edges send out alarm signals which, at appropriate intensity levels, generate programmed cell death. Depending on the extent and timing of the programmed cell death, the lesion may get controlled or aggravated akin to the control of wild fires by burning of peripheral vegetation. The parameter phase space of the model shows smooth transition from uncontrolled situation to controlled situation. The simulations show that the model is capable of generating a wide variety of lesion growth and arrest scenarios.

Resumo Limpo

simul model spread control lesion brain construct use planar network graph represent central nervous system cns model inspir lesion structur observ case multipl sclerosi ms chronic diseas cns initi lesion site center unit squar spread outward base success rate damag edg axon network damag edg send alarm signal appropri intens level generat program cell death depend extent time program cell death lesion may get control aggrav akin control wild fire burn peripher veget paramet phase space model show smooth transit uncontrol situat control situat simul show model capabl generat wide varieti lesion growth arrest scenario

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