Comput Math Methods Med - A wavelet transform based method to determine depth of anesthesia to prevent awareness during general anesthesia.

Tópicos

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Resumo

Awareness during general anesthesia for its serious psychological effects on patients and some juristically problems for anesthetists has been an important challenge during past decades. Monitoring depth of anesthesia is a fundamental solution to this problem. The induction of anesthesia alters frequency and mean of amplitudes of the electroencephalogram (EEG), and its phase couplings. We analyzed EEG changes for phase coupling between delta and alpha subbands using a new algorithm for depth of general anesthesia measurement based on complex wavelet transform (CWT) in patients anesthetized by Propofol. Entropy and histogram of modulated signals were calculated by taking bispectral index (BIS) values as reference. Entropies corresponding to different BIS intervals using Mann-Whitney U test showed that they had different continuous distributions. The results demonstrated that there is a phase coupling between 3 and 4Hz in delta and 8-9Hz in alpha subbands and these changes are shown better at the channel T 7 of EEG. Moreover, when BIS values increase, the entropy value of modulated signal also increases and vice versa. In addition, measuring phase coupling between delta and alpha subbands of EEG signals through continuous CWT analysis reveals the depth of anesthesia level. As a result, awareness during anesthesia can be prevented.

Resumo Limpo

awar general anesthesia serious psycholog effect patient jurist problem anesthetist import challeng past decad monitor depth anesthesia fundament solut problem induct anesthesia alter frequenc mean amplitud electroencephalogram eeg phase coupl analyz eeg chang phase coupl delta alpha subband use new algorithm depth general anesthesia measur base complex wavelet transform cwt patient anesthet propofol entropi histogram modul signal calcul take bispectr index bis valu refer entropi correspond differ bis interv use mannwhitney u test show differ continu distribut result demonstr phase coupl hz delta hz alpha subband chang shown better channel t eeg moreov bis valu increas entropi valu modul signal also increas vice versa addit measur phase coupl delta alpha subband eeg signal continu cwt analysi reveal depth anesthesia level result awar anesthesia can prevent

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