Comput Math Methods Med - Modeling the relationship between fluorodeoxyglucose uptake and tumor radioresistance as a function of the tumor microenvironment.

Tópicos

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Resumo

High fluorodeoxyglucose positron emission tomography (FDG-PET) uptake in tumors has often been correlated with increasing local failure and shorter overall survival, but the radiobiological mechanisms of this uptake are unclear. We explore the relationship between FDG-PET uptake and tumor radioresistance using a mechanistic model that considers cellular status as a function of microenvironmental conditions, including proliferating cells with access to oxygen and glucose, metabolically active cells with access to glucose but not oxygen, and severely hypoxic cells that are starving. However, it is unclear what the precise uptake levels of glucose should be for cells that receive oxygen and glucose versus cells that only receive glucose. Different potential FDG uptake profiles, as a function of the microenvironment, were simulated. Predicted tumor doses for 50% control (TD50) in 2Gy fractions were estimated for each assumed uptake profile and for various possible cell mixtures. The results support the hypothesis of an increased avidity of FDG for cells in the intermediate stress state (those receiving glucose but not oxygen) compared to well-oxygenated (and proliferating) cells.

Resumo Limpo

high fluorodeoxyglucos positron emiss tomographi fdgpet uptak tumor often correl increas local failur shorter overal surviv radiobiolog mechan uptak unclear explor relationship fdgpet uptak tumor radioresist use mechanist model consid cellular status function microenvironment condit includ prolifer cell access oxygen glucos metabol activ cell access glucos oxygen sever hypox cell starv howev unclear precis uptak level glucos cell receiv oxygen glucos versus cell receiv glucos differ potenti fdg uptak profil function microenviron simul predict tumor dose control td gy fraction estim assum uptak profil various possibl cell mixtur result support hypothesi increas avid fdg cell intermedi stress state receiv glucos oxygen compar welloxygen prolifer cell

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