Comput Math Methods Med - Optimal treatment strategy for a tumor model under immune suppression.

Tópicos

{ cancer(2502) breast(956) screen(824) }
{ model(3480) simul(1196) paramet(876) }
{ model(3404) distribut(989) bayesian(671) }
{ framework(1458) process(801) describ(734) }
{ health(1844) social(1437) communiti(874) }
{ patient(2315) diseas(1263) diabet(1191) }
{ problem(2511) optim(1539) algorithm(950) }
{ control(1307) perform(991) simul(935) }
{ medic(1828) order(1363) alert(1069) }
{ first(2504) two(1366) second(1323) }
{ activ(1452) weight(1219) physic(1104) }
{ system(1976) rule(880) can(841) }
{ treatment(1704) effect(941) patient(846) }
{ perform(999) metric(946) measur(919) }
{ activ(1138) subject(705) human(624) }
{ time(1939) patient(1703) rate(768) }
{ featur(3375) classif(2383) classifi(1994) }
{ case(1353) use(1143) diagnosi(1136) }
{ data(3963) clinic(1234) research(1004) }
{ studi(1410) differ(1259) use(1210) }
{ import(1318) role(1303) understand(862) }
{ studi(1119) effect(1106) posit(819) }
{ signal(2180) analysi(812) frequenc(800) }
{ group(2977) signific(1463) compar(1072) }
{ gene(2352) biolog(1181) express(1162) }
{ use(976) code(926) identifi(902) }
{ use(1733) differ(960) four(931) }
{ implement(1333) system(1263) develop(1122) }
{ decis(3086) make(1611) patient(1517) }
{ method(2212) result(1239) propos(1039) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ data(1737) use(1416) pattern(1282) }
{ inform(2794) health(2639) internet(1427) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
{ sequenc(1873) structur(1644) protein(1328) }
{ method(1219) similar(1157) match(930) }
{ imag(2830) propos(1344) filter(1198) }
{ network(2748) neural(1063) input(814) }
{ imag(2675) segment(2577) method(1081) }
{ take(945) account(800) differ(722) }
{ studi(2440) review(1878) systemat(933) }
{ motion(1329) object(1292) video(1091) }
{ assess(1506) score(1403) qualiti(1306) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ error(1145) method(1030) estim(1020) }
{ chang(1828) time(1643) increas(1301) }
{ learn(2355) train(1041) set(1003) }
{ concept(1167) ontolog(924) domain(897) }
{ clinic(1479) use(1117) guidelin(835) }
{ algorithm(1844) comput(1787) effici(935) }
{ extract(1171) text(1153) clinic(932) }
{ method(1557) propos(1049) approach(1037) }
{ data(1714) softwar(1251) tool(1186) }
{ design(1359) user(1324) use(1319) }
{ model(2220) cell(1177) simul(1124) }
{ care(1570) inform(1187) nurs(1089) }
{ general(901) number(790) one(736) }
{ method(984) reconstruct(947) comput(926) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ howev(809) still(633) remain(590) }
{ risk(3053) factor(974) diseas(938) }
{ research(1085) discuss(1038) issu(1018) }
{ system(1050) medic(1026) inform(1018) }
{ model(2341) predict(2261) use(1141) }
{ visual(1396) interact(850) tool(830) }
{ compound(1573) activ(1297) structur(1058) }
{ perform(1367) use(1326) method(1137) }
{ blood(1257) pressur(1144) flow(957) }
{ spatial(1525) area(1432) region(1030) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ state(1844) use(1261) util(961) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ cost(1906) reduc(1198) effect(832) }
{ sampl(1606) size(1419) use(1276) }
{ data(3008) multipl(1320) sourc(1022) }
{ intervent(3218) particip(2042) group(1664) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ analysi(2126) use(1163) compon(1037) }
{ structur(1116) can(940) graph(676) }
{ high(1669) rate(1365) level(1280) }
{ drug(1928) target(777) effect(648) }
{ result(1111) use(1088) new(759) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ process(1125) use(805) approach(778) }
{ method(1969) cluster(1462) data(1082) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

We propose a mathematical model describing tumor-immune interactions under immune suppression. These days evidences indicate that the immune suppression related to cancer contributes to its progression. The mathematical model for tumor-immune interactions would provide a new methodology for more sophisticated treatment options of cancer. To do this we have developed a system of 11 ordinary differential equations including the movement, interaction, and activation of NK cells, CD8(+)T-cells, CD4(+)T cells, regulatory T cells, and dendritic cells under the presence of tumor and cytokines and the immune interactions. In addition, we apply two control therapies, immunotherapy and chemotherapy to the model in order to control growth of tumor. Using optimal control theory and numerical simulations, we obtain appropriate treatment strategies according to the ratio of the cost for two therapies, which suggest an optimal timing of each administration for the two types of models, without and with immunosuppressive effects. These results mean that the immune suppression can have an influence on treatment strategies for cancer.

Resumo Limpo

propos mathemat model describ tumorimmun interact immun suppress day evid indic immun suppress relat cancer contribut progress mathemat model tumorimmun interact provid new methodolog sophist treatment option cancer develop system ordinari differenti equat includ movement interact activ nk cell cdtcell cdt cell regulatori t cell dendrit cell presenc tumor cytokin immun interact addit appli two control therapi immunotherapi chemotherapi model order control growth tumor use optim control theori numer simul obtain appropri treatment strategi accord ratio cost two therapi suggest optim time administr two type model without immunosuppress effect result mean immun suppress can influenc treatment strategi cancer

Resumos Similares

J. Med. Internet Res. - Do cancer patients tweet? Examining the twitter use of cancer patients in Japan. ( 0,79179899383152 )
J Med Syst - The effect of artificial neural network model combined with six tumor markers in auxiliary diagnosis of lung cancer. ( 0,784716335385749 )
Comput Math Methods Med - Computer implementation of a new therapeutic model for GBM tumor. ( 0,762294364759738 )
Med Biol Eng Comput - Measurement of bioelectric and acoustic profile of breast tissue using hybrid magnetoacoustic method for cancer detection. ( 0,759899519118116 )
J Med Syst - Thermography based breast cancer detection using texture features and Support Vector Machine. ( 0,752024616347261 )
J Med Syst - Breast alert: an on-line tool for predicting the lifetime risk of women breast cancer. ( 0,749039321189333 )
Comput Methods Programs Biomed - Ultrasound based application for intraglandular mapping of breast cancer. ( 0,739293991973026 )
Comput. Biol. Med. - Segmentation of histopathology HER2/neu images with fuzzy decision tree and Takagi-Sugeno reasoning. ( 0,735178458251259 )
Comput Math Methods Med - Delay differential model for tumour-immune response with chemoimmunotherapy and optimal control. ( 0,719148648493191 )
Comput Math Methods Med - Computer aided detection of breast density and mass, and visualization of other breast anatomical regions on mammograms using graph cuts. ( 0,714020031194829 )
AMIA Annu Symp Proc - Alignment and clustering of breast cancer patients by longitudinal treatment history. ( 0,706073250625101 )
Comput Math Methods Med - Modeling the spatial distribution of chronic tumor hypoxia: implications for experimental and clinical studies. ( 0,700893894229161 )
Comput Math Methods Med - Assessing the effects of estrogen on the dynamics of breast cancer. ( 0,700573829831007 )
Comput Methods Programs Biomed - Critical laboratory result reporting system in cancer patients. ( 0,698240386446118 )
Med Decis Making - The influence of disease risk on the optimal time interval between screens for the early detection of cancer: a mathematical approach. ( 0,697219981877972 )
Comput Math Methods Med - A mathematical model of cancer treatment by radiotherapy. ( 0,693779682733545 )
Comput Math Methods Med - An estrogen model: the relationship between body mass index, menopausal status, estrogen replacement therapy, and breast cancer risk. ( 0,684090884621864 )
BMC Med Inform Decis Mak - Accuracy validation of adjuvant! online in Taiwanese breast cancer patients--a 10-year analysis. ( 0,680929988229369 )
Comput Methods Programs Biomed - The classification of cancer stage microarray data. ( 0,680632766945919 )
BMC Med Inform Decis Mak - Essential pre-treatment imaging examinations in patients with endoscopically-diagnosed early gastric cancer. ( 0,67810025637779 )
J Med Syst - An improved decision support system for detection of lesions in mammograms using Differential Evolution Optimized Wavelet Neural Network. ( 0,675306969881646 )
Comput Methods Programs Biomed - A coarse-to-fine approach for segmenting melanocytic skin lesions in standard camera images. ( 0,67432218097056 )
Comput Methods Programs Biomed - Mammogram retrieval on similar mass lesions. ( 0,667037231598623 )
Comput. Biol. Med. - ICP: A novel approach to predict prognosis of prostate cancer with inner-class clustering of gene expression data. ( 0,663647725929035 )
AMIA Annu Symp Proc - Analysis of Breast Contour using Rotated Catenary. ( 0,663586358643135 )
Comput. Biol. Med. - Risk classification of cancer survival using ANN with gene expression data from multiple laboratories. ( 0,663452360636661 )
Comput Methods Programs Biomed - Automated estimation of disease recurrence in head and neck cancer using routine healthcare data. ( 0,66068894519334 )
Int J Health Geogr - Estrogen receptor positive breast cancers and their association with environmental factors. ( 0,659096346854478 )
Comput Math Methods Med - Modeling of non-small cell lung cancer volume changes during CT-based image guided radiotherapy: patterns observed and clinical implications. ( 0,658312884965919 )
Comput Methods Programs Biomed - An intelligent decision support algorithm for diagnosis of colorectal cancer through serum tumor markers. ( 0,64993660162886 )
Int J Med Inform - Evaluation of different features of an eHealth application for personalized illness management support: cancer patients' use and appraisal of usefulness. ( 0,644112810358848 )
Int J Med Inform - Redefining the sonography workflow through the application of a departmental computerized workflow management system. ( 0,642605090348459 )
Comput Math Methods Med - Artificial neural networks in mammography interpretation and diagnostic decision making. ( 0,638794461024697 )
Wiley Interdiscip Rev Syst Biol Med - Gut stem cells in tissue renewal and disease: methods, markers, and myths. ( 0,637803945881522 )
J. Med. Internet Res. - An online resource of digital stories about cancer genetics: qualitative study of patient preferences and information needs. ( 0,637179619147204 )
Comput Methods Programs Biomed - Breast density classification to reduce false positives in CADe systems. ( 0,635870300678973 )
BMC Med Inform Decis Mak - A model building exercise of mortality risk for Taiwanese women with breast cancer. ( 0,635255508487411 )
Comput. Aided Surg. - A method for three-dimensional evaluation and computer aided treatment of femoroacetabular impingement. ( 0,634998857245571 )
Lifetime Data Anal - The k-sample problem in a multi-state model and testing transition probability matrices. ( 0,631510758719342 )
J Am Med Inform Assoc - Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality. ( 0,628707851971652 )
Med Biol Eng Comput - In vitro electroretinogram for the study of the functionality of differentiated retinal pigment epithelium cells. ( 0,62521093486932 )
J Am Med Inform Assoc - Automatic classification of mammography reports by BI-RADS breast tissue composition class. ( 0,625169023990974 )
Med Decis Making - Patients' preferences and priorities regarding colorectal cancer screening. ( 0,624668922686926 )
Comput. Biol. Med. - Computer simulations on multiprobe freezing of irregularly shaped tumors. ( 0,622824834062416 )
Int J Med Robot - Robotic surgery for staging of serous papillary and clear cell carcinoma of the endometrium. ( 0,622525641498496 )
J Med Syst - Classification of benign and malignant breast masses based on shape and texture features in sonography images. ( 0,622395070791972 )
Int J Comput Assist Radiol Surg - Breast masses detection using phase portrait analysis and fuzzy inference systems. ( 0,620712164896343 )
Telemed J E Health - A content analysis of chronic diseases social groups on Facebook and Twitter. ( 0,618439361667347 )
Comput Math Methods Med - Microdosimetry for targeted alpha therapy of cancer. ( 0,616395236060097 )
Med Decis Making - Decision Regret following Treatment for Localized Breast Cancer: Is Regret Stable Over Time? ( 0,615601836326326 )
IEEE J Biomed Health Inform - Augmenting breath regulation using a mobile driven virtual reality therapy framework. ( 0,614982234800404 )
Med Decis Making - How does early detection by screening affect disease progression? Modeling estimated benefits in prostate cancer screening. ( 0,614575477099792 )
BMC Med Inform Decis Mak - Factors influencing the surgery intentions and choices of women with early breast cancer: the predictive utility of an extended theory of planned behaviour. ( 0,61431588424982 )
J Med Syst - Construction the model on the breast cancer survival analysis use support vector machine, logistic regression and decision tree. ( 0,614194917636574 )
Comput. Biol. Med. - Screening for cancer associated MiRNAs through co-gene, co-function and co-pathway analysis. ( 0,613179024630573 )
Comput. Biol. Med. - Thermal analysis of a three-dimensional breast model with embedded tumour using the transmission line matrix (TLM) method. ( 0,612840756881682 )
J. Med. Internet Res. - Benefits of peer support in online Japanese breast cancer communities: differences between lurkers and posters. ( 0,610190672089158 )
Med Decis Making - Comparison of surveillance strategies for low-risk bladder cancer patients. ( 0,609074825864524 )
J Clin Monit Comput - Potential of surface acoustic wave biosensors for early sepsis diagnosis. ( 0,607811743731955 )
Med Decis Making - Deceiving numbers: survival rates and their impact on doctors' risk communication. ( 0,606330614556187 )
Comput Methods Programs Biomed - Pectoral muscle segmentation: a review. ( 0,605105094719657 )
Comput Math Methods Med - Separable transition density in the hybrid model for tumor-immune system competition. ( 0,602982085668348 )
Lifetime Data Anal - Group sequential tests for long-term survival comparisons. ( 0,60198342149398 )
Int J Health Geogr - Correlation of the ratio of metastatic to non-metastatic cancer cases with the degree of socioeconomic deprivation among Texas counties. ( 0,601978066597081 )
Comput Methods Programs Biomed - A new algorithm for automatic vascular mapping of DCE-MRI of the breast: Clinical application of a potential new biomarker. ( 0,601840746620047 )
Comput Math Methods Med - Risk-adaptive volumetric modulated arc therapy using biological objective functions for subvolume boosting in radiotherapy. ( 0,601384779324264 )
Int J Comput Assist Radiol Surg - Value of CT, FDG PET-CT and serum tumor markers in staging recurrent colorectal cancer. ( 0,601111253312164 )
J Am Med Inform Assoc - An interactive Bayesian model for prediction of lymph node ratio and survival in pancreatic cancer patients. ( 0,599527956921176 )
J Med Syst - Microwave tomography analysis system for breast tumor detection. ( 0,597171143287857 )
Wiley Interdiscip Rev Syst Biol Med - Intercellular adhesion: mechanisms for growth and metastasis of epithelial cancers. ( 0,596284468209593 )
BMC Med Inform Decis Mak - An improved survivability prognosis of breast cancer by using sampling and feature selection technique to solve imbalanced patient classification data. ( 0,592297274664974 )
J Med Syst - Prediction of breast cancer using artificial neural networks. ( 0,592270241758746 )
Inform Health Soc Care - Spontaneously published illness stories on a website for young women with breast cancer: do writers and themes reflect the wider population? ( 0,591766404161274 )
Med Biol Eng Comput - Biomedical application of fuzzy association rules for identifying breast cancer biomarkers. ( 0,591160269415174 )
Int J Comput Assist Radiol Surg - Four-dimensional radiotherapeutic dose calculation using biomechanical respiratory motion description. ( 0,584645072361381 )
Comput Math Methods Med - Screening for cervical cancer using automated analysis of PAP-smears. ( 0,583772716093408 )
Comput Math Methods Med - Steady-state analysis of necrotic core formation for solid avascular tumors with time delays in regulatory apoptosis. ( 0,579199740528288 )
J Med Syst - Breast tissue image classification based on Semi-supervised Locality Discriminant Projection with Kernels. ( 0,577475840439185 )
J Med Syst - Mammographic image based breast tissue classification with kernel self-optimized fisher discriminant for breast cancer diagnosis. ( 0,577435976651371 )
J Digit Imaging - Presentation of similar images as a reference for distinction between benign and malignant masses on mammograms: analysis of initial observer study. ( 0,576830157809735 )
J Med Syst - Application of intelligent systems in asthma disease: designing a fuzzy rule-based system for evaluating level of asthma exacerbation. ( 0,575009559977792 )
Res Synth Methods - Network meta-analysis of parametric survival curves. ( 0,566139202843207 )
Comput Math Methods Med - Solutions of a linearized mathematical model for capillary formation in tumor angiogenesis: an initial data perturbation approximation. ( 0,564687525555863 )
J Am Med Inform Assoc - Automatic glaucoma diagnosis through medical imaging informatics. ( 0,564044187993686 )
Comput Math Methods Med - The value of private patient information in the physician-patient relationship: a game-theoretic account. ( 0,563320409011262 )
Comput Methods Programs Biomed - MRI-based finite element simulation on radiofrequency ablation of thyroid cancer. ( 0,562960495466747 )
BMC Med Inform Decis Mak - Public stated preferences and predicted uptake for genome-based colorectal cancer screening. ( 0,562691294615914 )
J. Med. Internet Res. - Cancer survivorship in the age of YouTube and social media: a narrative analysis. ( 0,561159840422882 )
Comput. Biol. Med. - Learning the local Bayesian network structure around the ZNF217 oncogene in breast tumours. ( 0,560875471461321 )
Brief. Bioinformatics - Breast cancer classification: linking molecular mechanisms to disease prognosis. ( 0,560274343604184 )
J Biomed Inform - Computer-aided detection of breast cancer on mammograms: a swarm intelligence optimized wavelet neural network approach. ( 0,558650806069525 )
Comput Math Methods Med - Evaluation of the diagnostic power of thermography in breast cancer using Bayesian network classifiers. ( 0,557003945341301 )
Comput. Biol. Med. - Automatic segmentation of lung nodules with growing neural gas and support vector machine. ( 0,556372991594128 )
Int J Med Inform - Internet based patient pathway as an educational tool for breast cancer patients. ( 0,556134419382101 )
Comput Methods Programs Biomed - Computer aided detection system for micro calcifications in digital mammograms. ( 0,554758007866853 )
Artif Intell Med - Pathway-based identification of a smoking associated 6-gene signature predictive of lung cancer risk and survival. ( 0,553844801610649 )
AMIA Annu Symp Proc - Adverse Drug Event-based Stratification of Tumor Mutations: A Case Study of Breast Cancer Patients Receiving Aromatase Inhibitors. ( 0,551868521949047 )
Res Synth Methods - Synthesis of survival and disease progression outcomes for health technology assessment of cancer therapies. ( 0,551437011609208 )
Comput Math Methods Med - A methodology for validating safety heuristics using clinical simulations: identifying and preventing possible technology-induced errors related to using health information systems. ( 0,550165422702268 )
Telemed J E Health - Mobile health is worth it! Economic benefit and impact on health of a population-based mobile screening program in new Mexico. ( 0,546870449443331 )