Comput Math Methods Med - Impact of dose and sensitivity heterogeneity on TCP.

Tópicos

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Resumo

This present paper presents an analytical description and numerical simulations of the influence of macroscopic intercell dose variations and intercell sensitivity variations on the probability of controlling the tumour. Computer simulations of tumour control probability accounting for heterogeneity in dose and radiation sensitivity were performed. An analytical expression for tumor control probability accounting for heterogeneity in sensitivity was also proposed and validated against simulations. The results show good agreement between numerical simulations and the calculated TCP using the proposed analytical expression for the case of a heterogeneous dose and sensitivity distributions. When the intratumour variations of dose and sensitivity are taken into account, the total dose required for achieving the same level of control as for the case of homogeneous distribution is only slightly higher, the influence of the variations in the two factors taken into account being additive. The results of this study show that the interplay between cell or tumour variation in the sensitivity to radiation and the inherent heterogeneity in dose distribution is highly complex and therefore should be taken into account when predicting the outcome of a given treatment in terms of tumor control probability.

Resumo Limpo

present paper present analyt descript numer simul influenc macroscop intercel dose variat intercel sensit variat probabl control tumour comput simul tumour control probabl account heterogen dose radiat sensit perform analyt express tumor control probabl account heterogen sensit also propos valid simul result show good agreement numer simul calcul tcp use propos analyt express case heterogen dose sensit distribut intratumour variat dose sensit taken account total dose requir achiev level control case homogen distribut slight higher influenc variat two factor taken account addit result studi show interplay cell tumour variat sensit radiat inher heterogen dose distribut high complex therefor taken account predict outcom given treatment term tumor control probabl

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