Comput Math Methods Med - Identification of crucial parameters in a mathematical multiscale model of glioblastoma growth.

Tópicos

{ model(2220) cell(1177) simul(1124) }
{ treatment(1704) effect(941) patient(846) }
{ compound(1573) activ(1297) structur(1058) }
{ drug(1928) target(777) effect(648) }
{ perform(1367) use(1326) method(1137) }
{ design(1359) user(1324) use(1319) }
{ model(3480) simul(1196) paramet(876) }
{ analysi(2126) use(1163) compon(1037) }
{ blood(1257) pressur(1144) flow(957) }
{ gene(2352) biolog(1181) express(1162) }
{ structur(1116) can(940) graph(676) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ algorithm(1844) comput(1787) effici(935) }
{ general(901) number(790) one(736) }
{ import(1318) role(1303) understand(862) }
{ implement(1333) system(1263) develop(1122) }
{ data(1737) use(1416) pattern(1282) }
{ system(1976) rule(880) can(841) }
{ bind(1733) structur(1185) ligand(1036) }
{ sequenc(1873) structur(1644) protein(1328) }
{ method(1219) similar(1157) match(930) }
{ imag(2830) propos(1344) filter(1198) }
{ network(2748) neural(1063) input(814) }
{ studi(2440) review(1878) systemat(933) }
{ framework(1458) process(801) describ(734) }
{ chang(1828) time(1643) increas(1301) }
{ concept(1167) ontolog(924) domain(897) }
{ clinic(1479) use(1117) guidelin(835) }
{ case(1353) use(1143) diagnosi(1136) }
{ risk(3053) factor(974) diseas(938) }
{ research(1085) discuss(1038) issu(1018) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }
{ model(3404) distribut(989) bayesian(671) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ inform(2794) health(2639) internet(1427) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ featur(3375) classif(2383) classifi(1994) }
{ take(945) account(800) differ(722) }
{ motion(1329) object(1292) video(1091) }
{ assess(1506) score(1403) qualiti(1306) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ problem(2511) optim(1539) algorithm(950) }
{ error(1145) method(1030) estim(1020) }
{ learn(2355) train(1041) set(1003) }
{ extract(1171) text(1153) clinic(932) }
{ method(1557) propos(1049) approach(1037) }
{ data(1714) softwar(1251) tool(1186) }
{ control(1307) perform(991) simul(935) }
{ care(1570) inform(1187) nurs(1089) }
{ method(984) reconstruct(947) comput(926) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ studi(1410) differ(1259) use(1210) }
{ perform(999) metric(946) measur(919) }
{ system(1050) medic(1026) inform(1018) }
{ model(2341) predict(2261) use(1141) }
{ visual(1396) interact(850) tool(830) }
{ studi(1119) effect(1106) posit(819) }
{ spatial(1525) area(1432) region(1030) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ state(1844) use(1261) util(961) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ health(1844) social(1437) communiti(874) }
{ high(1669) rate(1365) level(1280) }
{ cancer(2502) breast(956) screen(824) }
{ use(976) code(926) identifi(902) }
{ use(1733) differ(960) four(931) }
{ result(1111) use(1088) new(759) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ decis(3086) make(1611) patient(1517) }
{ process(1125) use(805) approach(778) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1969) cluster(1462) data(1082) }

Resumo

Glioblastomas are highly malignant brain tumours. Mathematical models and their analysis provide a tool to support the understanding of the development of these tumours as well as the design of more effective treatment strategies. We have previously developed a multiscale model of glioblastoma progression that covers processes on the cellular and molecular scale. Here, we present a novel nutrient-dependent multiscale sensitivity analysis of this model that helps to identify those reaction parameters of the molecular interaction network that influence the tumour progression on the cellular scale the most. In particular, those parameters are identified that essentially determine tumour expansion and could be therefore used as potential therapy targets. As indicators for the success of a potential therapy target, a deceleration of the tumour expansion and a reduction of the tumour volume are employed. From the results, it can be concluded that no single parameter variation results in a less aggressive tumour. However, it can be shown that a few combined perturbations of two systematically selected parameters cause a slow-down of the tumour expansion velocity accompanied with a decrease of the tumour volume. Those parameters are primarily linked to the reactions that involve the microRNA-451 and the thereof regulated protein MO25.

Resumo Limpo

glioblastoma high malign brain tumour mathemat model analysi provid tool support understand develop tumour well design effect treatment strategi previous develop multiscal model glioblastoma progress cover process cellular molecular scale present novel nutrientdepend multiscal sensit analysi model help identifi reaction paramet molecular interact network influenc tumour progress cellular scale particular paramet identifi essenti determin tumour expans therefor use potenti therapi target indic success potenti therapi target deceler tumour expans reduct tumour volum employ result can conclud singl paramet variat result less aggress tumour howev can shown combin perturb two systemat select paramet caus slowdown tumour expans veloc accompani decreas tumour volum paramet primarili link reaction involv microrna thereof regul protein mo

Resumos Similares

Comput Math Methods Med - Effective admittivity of biological tissues as a coefficient of elliptic PDE. ( 0,716264333945897 )
J Clin Monit Comput - Analysis of a mathematical model of apoptosis: individual differences and malfunction in programmed cell death. ( 0,687420166299548 )
Sci Data - Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies. ( 0,65875496068625 )
J Chem Inf Model - Identification of compounds with potential antibacterial activity against Mycobacterium through structure-based drug screening. ( 0,639629383402914 )
Comput. Biol. Med. - Mathematical model of the coagulation in the bone-dental implant interface. ( 0,63475964911837 )
J Chem Inf Model - Consensus ranking approach to understanding the underlying mechanism with QSAR. ( 0,620597939256162 )
J Chem Inf Model - Discovery of novel selective serotonin reuptake inhibitors through development of a protein-based pharmacophore. ( 0,612811274378677 )
Comput Math Methods Med - On the stability of lung parenchymal lesions with applications to early pneumothorax diagnosis. ( 0,611994996745925 )
Comput Methods Programs Biomed - Optimal bone density distributions: numerical analysis of the osteocyte spatial influence in bone remodeling. ( 0,603008591024365 )
J Med Syst - Thermal shock resistance of skin tissue. ( 0,597193215452962 )
Med Biol Eng Comput - A model for simulation and patient-specific visualization of the tissue volume of influence during brain microdialysis. ( 0,593530826148785 )
Med Biol Eng Comput - Influence of ischemic core muscle fibers on surface depolarization potentials in superfused cardiac tissue preparations: a simulation study. ( 0,591297221318957 )
Comput Math Methods Med - Simulation of arrhythmogenic effect of rogue RyRs in failing heart by using a coupled model. ( 0,591242367377077 )
Med Biol Eng Comput - Continuous flow left ventricular pump support and its effect on regional left ventricular wall stress: finite element analysis study. ( 0,585571375339026 )
Med Biol Eng Comput - Biomechanical analysis of traumatic mesenteric avulsion. ( 0,585501245795133 )
Comput Math Methods Med - Circadian models of serum potassium, sodium, and calcium concentrations in healthy individuals and their application to cardiac electrophysiology simulations at individual level. ( 0,585174423974639 )
Wiley Interdiscip Rev Syst Biol Med - Computational and experimental characterization of skin mechanics: identifying current challenges and future directions. ( 0,583100904987351 )
Med Biol Eng Comput - Multi-scale study of nanoparticle transport and deposition in tissues during an injection process. ( 0,582255327601472 )
Med Biol Eng Comput - 3D network model of NO transport in tissue. ( 0,582179099304847 )
J. Comput. Biol. - Cytopede: a three-dimensional tool for modeling cell motility on a flat surface. ( 0,581812750451499 )
Comput Methods Programs Biomed - Development and application of efficient pathway enumeration algorithms for metabolic engineering applications. ( 0,580887058971793 )
J Chem Inf Model - Structure and ligand-based design of mTOR and PI3-kinase inhibitors leading to the clinical candidates VS-5584 (SB2343) and SB2602. ( 0,576940710717142 )
Comput. Biol. Med. - Prediction of stress shielding around an orthopedic screw: using stress and strain energy density as mechanical stimuli. ( 0,574175690190098 )
Comput Methods Programs Biomed - External fixator configurations in tibia fractures: 1D optimization and 3D analysis comparison. ( 0,573752355667279 )
Comput. Biol. Med. - Self-expanding aortic valve stent-material optimization. ( 0,572771089286818 )
Wiley Interdiscip Rev Syst Biol Med - Fatty acid oxidation: systems analysis and applications. ( 0,572101459464158 )
Med Biol Eng Comput - Modeling the pharyngeal anatomical effects on breathing resistance and aerodynamically generated sound. ( 0,5686743796638 )
Wiley Interdiscip Rev Syst Biol Med - Integrative approaches for modeling regulation and function of the respiratory system. ( 0,568140275913627 )
Comput Methods Programs Biomed - 3D hybrid wound devices for spatiotemporally controlled release kinetics. ( 0,563606245902257 )
Med Biol Eng Comput - In-silico modeling of atrial repolarization in normal and atrial fibrillation remodeled state. ( 0,561787458262292 )
Comput Math Methods Med - Pressure dynamic characteristics of pressure controlled ventilation system of a lung simulator. ( 0,561097941786812 )
Int J Comput Assist Radiol Surg - Surgical stent planning: simulation parameter study for models based on DICOM standards. ( 0,559743564102733 )
J Biomed Inform - Efficient computation of interacting model systems. ( 0,558715222781783 )
Comput Math Methods Med - Morphological measurement of living cells in methanol with digital holographic microscopy. ( 0,556596972487244 )
Comput Methods Programs Biomed - An FDTD-based computer simulation platform for shock wave propagation in electrohydraulic lithotripsy. ( 0,556442437221081 )
Med Biol Eng Comput - Biomechanical modeling of brace treatment of scoliosis: effects of gravitational loads. ( 0,548565284308614 )
Comput Methods Programs Biomed - A phenomenological mathematical model of the articular cartilage damage. ( 0,548217653565789 )
Comput Math Methods Med - Superficial collagen fibril modulus and pericellular fixed charge density modulate chondrocyte volumetric behaviour in early osteoarthritis. ( 0,547116075618915 )
Comput. Biol. Med. - Drug perfusion enhancement in tissue model by steady streaming induced by oscillating microbubbles. ( 0,546503343623774 )
Med Biol Eng Comput - The effects of femoral neck cut, cable tension, and muscles forces on the greater trochanter fixation. ( 0,544919962578738 )
J Am Med Inform Assoc - Determining molecular predictors of adverse drug reactions with causality analysis based on structure learning. ( 0,544669944583672 )
Comput. Biol. Med. - A computerized decision support system to predict the variations in the cerebral blood flow of mechanically ventilated infants. ( 0,544583221146881 )
Comput Methods Programs Biomed - Drug release profile in core-shell nanofibrous structures: a study on Peppas equation and artificial neural network modeling. ( 0,544570556308973 )
Comput Biol Chem - A structural comparative approach to identifying novel antimalarial inhibitors. ( 0,544512727005817 )
Comput Methods Programs Biomed - Assessing bone loss in micro-gravity: a fuzzy approach. ( 0,544356359440671 )
Comput Methods Programs Biomed - Computer simulation of structured treatment interruption for HIV infection. ( 0,543708650224305 )
Neural Comput - Ambient GABA responsible for age-related changes in multistable perception. ( 0,543091865479058 )
Wiley Interdiscip Rev Syst Biol Med - Vascular tissue engineering: from in vitro to in situ. ( 0,542435187367137 )
Med Biol Eng Comput - 3D dynamic position assessment of the coronary sinus lead in cardiac resynchronization therapy. ( 0,540878398855377 )
Med Biol Eng Comput - Sensitivity studies of pediatric material properties on juvenile lumbar spine responses using finite element analysis. ( 0,540757801170935 )
Brief. Bioinformatics - Similarity-based machine learning methods for predicting drug-target interactions: a brief review. ( 0,540751815685704 )
Int J Comput Assist Radiol Surg - Validation and prediction of traditional Chinese physical operation on spinal disease using multiple deformation models. ( 0,539663025536987 )
Med Biol Eng Comput - Effect of femoral neck modularity upon the prosthetic range of motion in total hip arthroplasty. ( 0,539635284366874 )
Med Biol Eng Comput - Temporal evolution of skeletal regenerated tissue: what can mechanical investigation add to biological? ( 0,539562212783849 )
Comput. Biol. Med. - Accurate computation of traveling wavefronts in a biological hydrodynamic model. ( 0,539097346480847 )
J Chem Inf Model - Design of novel rho kinase inhibitors using energy based pharmacophore modeling, shape-based screening, in silico virtual screening, and biological evaluation. ( 0,538827204188539 )
Med Biol Eng Comput - Computer simulation of three-dimensional plaque formation and progression in the carotid artery. ( 0,538650737766932 )
Comput. Biol. Med. - A computational study of the respiratory airflow characteristics in normal and obstructed human airways. ( 0,537600287536419 )
Comput. Biol. Med. - Protein transport in the connecting cilium of a photoreceptor cell: modeling the effects of bidirectional protein transitions between the diffusion-driven and motor-driven kinetic states. ( 0,534617923125825 )
IEEE Trans Vis Comput Graph - A Hexahedral Multigrid Approach for Simulating Cuts in Deformable Objects. ( 0,533520566385734 )
Med Biol Eng Comput - Can common adhesion molecules and microtopography affect cellular elasticity? A combined atomic force microscopy and optical study. ( 0,532756151050455 )
J Chem Inf Model - Discovery of inhibitors of Schistosoma mansoni HDAC8 by combining homology modeling, virtual screening, and in vitro validation. ( 0,532429108369068 )
J Chem Inf Model - Predicting drug-target interactions using probabilistic matrix factorization. ( 0,530522605752646 )
Comput. Biol. Med. - Predicting DNA-mediated drug delivery in interior carcinoma using electromagnetically excited nanoparticles. ( 0,530298574749326 )
J Chem Inf Model - Identification of small-molecule inhibitors against human leukocyte antigen-death receptor 4 (HLA-DR4) through a comprehensive strategy. ( 0,529820115011705 )
Med Biol Eng Comput - Biomechanical comparison of fusionless growth modulation corrective techniques in pediatric scoliosis. ( 0,529303403036845 )
Comput. Biol. Med. - Computational study of thermal effects of large blood vessels in human knee joint. ( 0,527892133860423 )
Comput. Biol. Med. - Computer-aided design of the human aortic root. ( 0,527667919272015 )
Wiley Interdiscip Rev Syst Biol Med - A systems biology approach to synovial joint lubrication in health, injury, and disease. ( 0,526792857487086 )
Wiley Interdiscip Rev Syst Biol Med - Virtual Cell: computational tools for modeling in cell biology. ( 0,52656647037057 )
J Chem Inf Model - Structural insights into trapping and dissociation of small molecules in K channels. ( 0,52631145277141 )
Comput Math Methods Med - The effect of inhibitory neuron on the evolution model of higher-order coupling neural oscillator population. ( 0,526008928877093 )
Wiley Interdiscip Rev Syst Biol Med - Glass-like dynamics in the cell and in cellular collectives. ( 0,525288617153005 )
Comput Methods Programs Biomed - Growth of the flat bones of the membranous neurocranium: a computational model. ( 0,524698950603148 )
Med Biol Eng Comput - A three-dimensional finite element model of the cervical spine: an investigation of whiplash injury. ( 0,524684489733853 )
Comput Math Methods Med - Simulations of complex and microscopic models of cardiac electrophysiology powered by multi-GPU platforms. ( 0,52390679577393 )
Comput Math Methods Med - Extended finite element method with simplified spherical harmonics approximation for the forward model of optical molecular imaging. ( 0,523548408312279 )
Comput Math Methods Med - A mathematical model of immune-system-melanoma competition. ( 0,523548408312279 )
Comput Math Methods Med - Comparative evaluation of osseointegrated dental implants based on platform-switching concept: influence of diameter, length, thread shape, and in-bone positioning depth on stress-based performance. ( 0,523033617174093 )
Int J Comput Assist Radiol Surg - NiftySim: A GPU-based nonlinear finite element package for simulation of soft tissue biomechanics. ( 0,523023958840758 )
Comput Math Methods Med - A review of the combination of experimental measurements and fibril-reinforced modeling for investigation of articular cartilage and chondrocyte response to loading. ( 0,52263461272671 )
Comput Math Methods Med - A literature review of the numerical analysis of abdominal aortic aneurysms treated with endovascular stent grafts. ( 0,522618787542751 )
Comput Math Methods Med - Quantitative imaging of young's modulus of soft tissues from ultrasound water jet indentation: a finite element study. ( 0,521574003539046 )
Comput. Biol. Med. - First-principles modeling of fluid and solute exchange in the human during normal and hemodialysis conditions. ( 0,521274498211383 )
J Chem Inf Model - admetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties. ( 0,520314048834239 )
Med Biol Eng Comput - Investigation of foot plantar pressure: experimental and numerical analysis. ( 0,520054854173446 )
Med Biol Eng Comput - Mechanical and microarchitectural analyses of cancellous bone through experiment and computer simulation. ( 0,519928282264319 )
Comput. Biol. Med. - Design, analysis and verification of a knee joint oncological prosthesis finite element model. ( 0,519753100881917 )
Int J Comput Assist Radiol Surg - Bivariate optimization of orthodontic mini-implant thread height and pitch. ( 0,519148743013137 )
J Biomed Inform - Drug target identification in sphingolipid metabolism by computational systems biology tools: metabolic control analysis and metabolic pathway analysis. ( 0,517565953225547 )
Comput Math Methods Med - Dynamics of posttranslational modifications of p53. ( 0,517503205726289 )
J Chem Inf Model - Lid closure mechanism of Yarrowia lipolytica lipase in methanol investigated by molecular dynamics simulation. ( 0,517274116020998 )
Med Biol Eng Comput - Biomechanical analysis of the effects of medial meniscectomy on degenerative osteoarthritis. ( 0,517176865407144 )
Med Biol Eng Comput - Estimation of the retainer height biomechanical contribution in posterior resin-bonded fixed partial dentures: a structural-thermal coupled finite element analysis. ( 0,517101656090175 )
J Chem Inf Model - Plane of best fit: a novel method to characterize the three-dimensionality of molecules. ( 0,516709554822575 )
Med Biol Eng Comput - Effects of simulated injury on the anteroinferior glenohumeral capsule. ( 0,516505843691322 )
Comput. Biol. Med. - Revealing pharmacodynamics of medicinal plants using in silico approach: a case study with wet lab validation. ( 0,515551507416294 )
Wiley Interdiscip Rev Syst Biol Med - Reprogramming cells and tissue patterning via bioelectrical pathways: molecular mechanisms and biomedical opportunities. ( 0,515436270357512 )
Comput Math Methods Med - Modelling tumour oxygenation, reoxygenation and implications on treatment outcome. ( 0,515091634979771 )
Med Biol Eng Comput - A new method to include the gravitational forces in a finite element model of the scoliotic spine. ( 0,514927369808993 )