Comput Math Methods Med - A new ratio for protocol categorization.

Tópicos

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Resumo

The present review describes and validates a new ratio "S" created for matching predictability and balance between TP and TN. Validity of S was studied in a three-step process as follows: (i) S was applied to the data of a past study predicting cardiac output response to fluid bolus from response to passive leg raise (PLR); (ii) S was comparatively analyzed with traditional ratios by modeling different 2 * 2 contingency tables in 1000 hypothetical patients; (iii) precision of S was compared with other ratios by computing random fluctuations in the same patients. In comparison to other ratios, S performs better in predicting the cardiac response to fluid bolus and supports more directly the clinical conclusions. When the proportion of false responses is high, S is close to the coefficient correlation (CC). When the proportion of true responses is high, S is the unique ratio that identifies the categorization that balances the proportion of TP and TN. The precision of S is close to that of CC. In conclusion, S should be considered for creating categories from quantitative variables; especially when matching predictability with balance between TP and TN is a concern.

Resumo Limpo

present review describ valid new ratio s creat match predict balanc tp tn valid s studi threestep process follow s appli data past studi predict cardiac output respons fluid bolus respons passiv leg rais plr ii s compar analyz tradit ratio model differ conting tabl hypothet patient iii precis s compar ratio comput random fluctuat patient comparison ratio s perform better predict cardiac respons fluid bolus support direct clinic conclus proport fals respons high s close coeffici correl cc proport true respons high s uniqu ratio identifi categor balanc proport tp tn precis s close cc conclus s consid creat categori quantit variabl especi match predict balanc tp tn concern

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