Comput Math Methods Med - The relationship between the 24h blood pressure variability and carotid intima-media thickness: a compared study.

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Resumo

Large blood pressure variability (BPV) will not only harm the target organ but also increase the possibility of the cardiovascular events. Since the damage of vascular system always leads to the alteration of the carotid wall, the structure and function of the carotid artery have been extensively examined in previous studies. In this work we conduct a study (60 subjects, aged 33-79) to evaluate the relationship between BPV and carotid intima-media thickness (IMT) in Shenzhen, which is one large city in the southern area of China. In our study, the blood pressure (BP) was collected using the 24h ambulatory BP monitoring, and the BPV was evaluated using standard deviation (SD), coefficient of variation (CV), and average real variability (ARV) during 24h, daytime and nighttime. All the IMT measurements are collected by ultrasound. The results show that both the daytime, and 24h systolic BPV evaluated by three indices are positively associated with IMT. Among them, daytime systolic BPV evaluated with ARV is the best variable to represent the increasing of carotid IMT. In addition, after adjusting by age, sex, smoking, hypertension, and mean BP and PP values, 24h diastolic BPV evaluated with SD also presents the favorable performance.

Resumo Limpo

larg blood pressur variabl bpv will harm target organ also increas possibl cardiovascular event sinc damag vascular system alway lead alter carotid wall structur function carotid arteri extens examin previous studi work conduct studi subject age evalu relationship bpv carotid intimamedia thick imt shenzhen one larg citi southern area china studi blood pressur bp collect use h ambulatori bp monitor bpv evalu use standard deviat sd coeffici variat cv averag real variabl arv h daytim nighttim imt measur collect ultrasound result show daytim h systol bpv evalu three indic posit associ imt among daytim systol bpv evalu arv best variabl repres increas carotid imt addit adjust age sex smoke hypertens mean bp pp valu h diastol bpv evalu sd also present favor perform

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