Comput Math Methods Med - Mathematical modeling of transmission dynamics and optimal control of vaccination and treatment for hepatitis B virus.

Tópicos

{ model(3480) simul(1196) paramet(876) }
{ treatment(1704) effect(941) patient(846) }
{ problem(2511) optim(1539) algorithm(950) }
{ state(1844) use(1261) util(961) }
{ general(901) number(790) one(736) }
{ imag(1057) registr(996) error(939) }
{ assess(1506) score(1403) qualiti(1306) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ inform(2794) health(2639) internet(1427) }
{ take(945) account(800) differ(722) }
{ motion(1329) object(1292) video(1091) }
{ algorithm(1844) comput(1787) effici(935) }
{ design(1359) user(1324) use(1319) }
{ case(1353) use(1143) diagnosi(1136) }
{ visual(1396) interact(850) tool(830) }
{ studi(1119) effect(1106) posit(819) }
{ health(3367) inform(1360) care(1135) }
{ cost(1906) reduc(1198) effect(832) }
{ can(981) present(881) function(850) }
{ structur(1116) can(940) graph(676) }
{ result(1111) use(1088) new(759) }
{ implement(1333) system(1263) develop(1122) }
{ model(3404) distribut(989) bayesian(671) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ data(1737) use(1416) pattern(1282) }
{ system(1976) rule(880) can(841) }
{ measur(2081) correl(1212) valu(896) }
{ bind(1733) structur(1185) ligand(1036) }
{ sequenc(1873) structur(1644) protein(1328) }
{ method(1219) similar(1157) match(930) }
{ featur(3375) classif(2383) classifi(1994) }
{ imag(2830) propos(1344) filter(1198) }
{ network(2748) neural(1063) input(814) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ studi(2440) review(1878) systemat(933) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ framework(1458) process(801) describ(734) }
{ error(1145) method(1030) estim(1020) }
{ chang(1828) time(1643) increas(1301) }
{ learn(2355) train(1041) set(1003) }
{ concept(1167) ontolog(924) domain(897) }
{ clinic(1479) use(1117) guidelin(835) }
{ extract(1171) text(1153) clinic(932) }
{ method(1557) propos(1049) approach(1037) }
{ data(1714) softwar(1251) tool(1186) }
{ control(1307) perform(991) simul(935) }
{ model(2220) cell(1177) simul(1124) }
{ care(1570) inform(1187) nurs(1089) }
{ method(984) reconstruct(947) comput(926) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ studi(1410) differ(1259) use(1210) }
{ risk(3053) factor(974) diseas(938) }
{ perform(999) metric(946) measur(919) }
{ research(1085) discuss(1038) issu(1018) }
{ system(1050) medic(1026) inform(1018) }
{ import(1318) role(1303) understand(862) }
{ model(2341) predict(2261) use(1141) }
{ compound(1573) activ(1297) structur(1058) }
{ perform(1367) use(1326) method(1137) }
{ blood(1257) pressur(1144) flow(957) }
{ spatial(1525) area(1432) region(1030) }
{ record(1888) medic(1808) patient(1693) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
{ gene(2352) biolog(1181) express(1162) }
{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ analysi(2126) use(1163) compon(1037) }
{ health(1844) social(1437) communiti(874) }
{ high(1669) rate(1365) level(1280) }
{ cancer(2502) breast(956) screen(824) }
{ use(976) code(926) identifi(902) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ decis(3086) make(1611) patient(1517) }
{ process(1125) use(805) approach(778) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1969) cluster(1462) data(1082) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

Hepatitis B virus (HBV) infection is a worldwide public health problem. In this paper, we study the dynamics of hepatitis B virus (HBV) infection which can be controlled by vaccination as well as treatment. Initially we consider constant controls for both vaccination and treatment. In the constant controls case, by determining the basic reproduction number, we study the existence and stability of the disease-free and endemic steady-state solutions of the model. Next, we take the controls as time and formulate the appropriate optimal control problem and obtain the optimal control strategy to minimize both the number of infectious humans and the associated costs. Finally at the end numerical simulation results show that optimal combination of vaccination and treatment is the most effective way to control hepatitis B virus infection.

Resumo Limpo

hepat b virus hbv infect worldwid public health problem paper studi dynam hepat b virus hbv infect can control vaccin well treatment initi consid constant control vaccin treatment constant control case determin basic reproduct number studi exist stabil diseasefre endem steadyst solut model next take control time formul appropri optim control problem obtain optim control strategi minim number infecti human associ cost final end numer simul result show optim combin vaccin treatment effect way control hepat b virus infect

Resumos Similares

Comput Math Methods Med - A mathematical study of a TB Model with treatment interruptions and two latent periods. ( 0,791674279796857 )
Comput Math Methods Med - Dynamics analysis and simulation of a modified HIV infection model with a saturated infection rate. ( 0,738301179204111 )
Comput Math Methods Med - A theoretical model for the transmission dynamics of the Buruli ulcer with saturated treatment. ( 0,730641199584972 )
Comput. Biol. Med. - Modeling multiple experiments using regularized optimization: A case study on bacterial glucose utilization dynamics. ( 0,713724391629719 )
Comput Math Methods Med - Modeling schistosomiasis and HIV/AIDS codynamics. ( 0,680969538375339 )
Comput Math Methods Med - Fast parameters estimation in medication efficacy assessment model for heart failure treatment. ( 0,678553683645285 )
Comput Math Methods Med - Analytical solutions for the mathematical model describing the formation of liver zones via Adomian's method. ( 0,663936042927906 )
Comput Methods Programs Biomed - Solving delay differential equations in S-ADAPT by method of steps. ( 0,650801584163482 )
Comput Biol Chem - A state-time epidemiology model of tuberculosis: importance of re-infection. ( 0,645572630315632 )
Wiley Interdiscip Rev Syst Biol Med - Glass-like dynamics in the cell and in cellular collectives. ( 0,639639867828788 )
Comput. Biol. Med. - Computing the stability of steady-state solutions of mathematical models of the electrical activity in the heart. ( 0,639108285855931 )
Comput Methods Programs Biomed - An efficient passive planar micromixer with ellipse-like micropillars for continuous mixing of human blood. ( 0,632982688226078 )
Brief. Bioinformatics - Choosing appropriate models for protein-protein interaction networks: a comparison study. ( 0,617919263381611 )
IEEE Trans Image Process - Reinitialization-free level set evolution via reaction diffusion. ( 0,614619320980966 )
Comput Methods Programs Biomed - Reprint of Pharmacokinetic modelling of the anti-malarial drug artesunate and its active metabolite dihydroartemisinin. ( 0,614378249223978 )
Comput Math Methods Med - Noninvasive monitoring of hepatic damage from hepatitis C virus infection. ( 0,612220737980418 )
IEEE Trans Image Process - Box relaxation schemes in staggered discretizations for the dual formulation of total variation minimization. ( 0,607853315874334 )
Comput Math Methods Med - ModeLang: a new approach for experts-friendly viral infections modeling. ( 0,604083990316323 )
Comput Math Methods Med - Solutions of a linearized mathematical model for capillary formation in tumor angiogenesis: an initial data perturbation approximation. ( 0,603259433177557 )
Comput. Biol. Med. - Modelling and simulating reaction-diffusion systems using coloured Petri nets. ( 0,603252512960547 )
J Integr Bioinform - An advanced environment for hybrid modeling of biological systems based on modelica. ( 0,599248479085497 )
Comput. Biol. Med. - Mathematical modeling of brain glioma growth using modified reaction-diffusion equation on brain MR images. ( 0,596991635978542 )
Comput Math Methods Med - Variational principles for buckling of microtubules modeled as nonlocal orthotropic shells. ( 0,593243038860816 )
Comput Math Methods Med - Computational modeling of microabscess formation. ( 0,592059856576842 )
Neural Comput - Cross-talk induces bifurcations in nonlinear models of synaptic plasticity. ( 0,591778888696327 )
Comput. Biol. Med. - Network and Nakamura tridiagonal computational simulation of electrically-conducting biopolymer micro-morphic transport phenomena. ( 0,58978558309431 )
Comput Biol Chem - An efficient nonlinear finite-difference approach in the computational modeling of the dynamics of a nonlinear diffusion-reaction equation in microbial ecology. ( 0,588697908200939 )
Lifetime Data Anal - Bayesian dynamic regression models for interval censored survival data with application to children dental health. ( 0,585490593739808 )
Med Decis Making - Cross-cultural evaluation of the WHOQOL-BREF domains in primary care depressed patients using Rasch analysis. ( 0,580544957660116 )
Comput Math Methods Med - Global stability analysis of SEIR model with holling type II incidence function. ( 0,57797578429095 )
Neural Comput - Computing confidence intervals for point process models. ( 0,576733056053753 )
Comput Methods Programs Biomed - Feedback controlled electrical nerve stimulation: a computer simulation. ( 0,575769245612468 )
Comput. Biol. Med. - ODE/PDE analysis of corneal curvature. ( 0,57570409254835 )
IEEE Trans Neural Netw Learn Syst - Discrete-Time Zhang Neural Network for Online Time-Varying Nonlinear Optimization With Application to Manipulator Motion Generation. ( 0,575564041111245 )
Comput Math Methods Med - Numerical solutions for a model of tissue invasion and migration of tumour cells. ( 0,573904447569232 )
Comput Biol Chem - A stochastic evolution model for residue Insertion-Deletion Independent from Substitution. ( 0,56511821416693 )
Comput Methods Programs Biomed - Computer simulation of structured treatment interruption for HIV infection. ( 0,56349627715732 )
Methods Inf Med - A negative feedback model for a mechanism based description of longitudinal observations. Application for bone turnover biomarkers. ( 0,56309760460736 )
Neural Comput - Analytical integrate-and-fire neuron models with conductance-based dynamics and realistic postsynaptic potential time course for event-driven simulation strategies. ( 0,56260162601626 )
Comput Methods Programs Biomed - First pilot trial of the STAR-Liege protocol for tight glycemic control in critically ill patients. ( 0,561301431836731 )
Comput Math Methods Med - Improved reconstruction quality of bioluminescent images by combining SP(3) equations and Bregman iteration method. ( 0,561160676670612 )
Neural Comput - Effect of phase response curve skewness on synchronization of electrically coupled neuronal oscillators. ( 0,560975609756098 )
Comput Math Methods Med - Global hopf bifurcation on two-delays leslie-gower predator-prey system with a prey refuge. ( 0,560152690674634 )
Comput Methods Programs Biomed - Parametric-based brain Magnetic Resonance Elastography using a Rayleigh damping material model. ( 0,559925965097508 )
Comput Methods Programs Biomed - Functionality of the baroreceptor nerves in heart rate regulation. ( 0,559543967903229 )
J. Med. Internet Res. - Comparing in-person to videoconference-based cognitive behavioral therapy for mood and anxiety disorders: randomized controlled trial. ( 0,558253346071215 )
Comput Methods Programs Biomed - Biomechanical analyses of static and dynamic fixation techniques of retrograde interlocking femoral nailing using nonlinear finite element methods. ( 0,558060909148619 )
Comput Math Methods Med - Disease control of delay SEIR model with nonlinear incidence rate and vertical transmission. ( 0,557651871471887 )
Comput Methods Programs Biomed - Accounting for large deformations in real-time simulations of soft tissues based on reduced-order models. ( 0,556477516371433 )
IEEE Trans Image Process - New class tiling design for dot-diffused halftoning. ( 0,555887217880378 )
IEEE Trans Image Process - Efficiency of semi-implicit schemes for anisotropic diffusion in the hypercube. ( 0,555285541714054 )
Comput. Biol. Med. - Examples of testing global identifiability of biological and biomedical models with the DAISY software. ( 0,554827223521803 )
IEEE Trans Pattern Anal Mach Intell - Maximal Linear Embedding for Dimensionality Reduction. ( 0,553759590760481 )
J. Med. Internet Res. - Development and initial evaluation of an Internet-based support system for face-to-face cognitive behavior therapy: a proof of concept study. ( 0,553255267879737 )
Comput Methods Programs Biomed - Innovative model to simulate exhalation phase in human respiratory system. ( 0,550502886137929 )
IEEE Trans Pattern Anal Mach Intell - Bi-polynomial Modeling of Low-frequency Reflectances. ( 0,549961492194717 )
Comput Methods Programs Biomed - 3D hybrid wound devices for spatiotemporally controlled release kinetics. ( 0,548556576438922 )
J. Comput. Biol. - Is an intuitive convergence definition of molecular dynamics simulations solely based on the root mean square deviation possible? ( 0,548553516912286 )
Comput. Biol. Med. - A synergic simulation-optimization approach for analyzing biomolecular dynamics in living organisms. ( 0,548143354178283 )
Med Biol Eng Comput - CSF dynamic analysis of a predictive pulsatility-based infusion test for normal pressure hydrocephalus. ( 0,548020507297972 )
Comput. Biol. Med. - Semi-computational simulation of magneto-hemodynamic flow in a semi-porous channel using optimal homotopy and differential transform methods. ( 0,54682261633355 )
Comput. Biol. Med. - Phase lagging model of brain response to external stimuli-modeling of single action potential. ( 0,546745343117555 )
Med Biol Eng Comput - A fluid-structure interaction model of the aortic valve with coaptation and compliant aortic root. ( 0,545246749386272 )
Comput. Biol. Med. - A compartment model of alveolar-capillary oxygen diffusion with ventilation-perfusion gradient and dynamics of air transport through the respiratory tract. ( 0,544200593662457 )
J. Med. Internet Res. - Posttreatment attrition and its predictors, attrition bias, and treatment efficacy of the anxiety online programs. ( 0,544066047247787 )
J Chem Inf Model - Fitting of dihedral terms in classical force fields as an analytic linear least-squares problem. ( 0,542537259221882 )
J Clin Monit Comput - The standard strong ion difference, standard total titratable base, and their relationship to the Boston compensation rules and the Van Slyke equation for extracellular fluid. ( 0,541733235291413 )
IEEE Trans Image Process - Vectorial total variation-based regularization for variational image registration. ( 0,540298890337836 )
Comput Methods Programs Biomed - Development of a computer algorithm for feedback controlled electrical nerve fiber stimulation. ( 0,539887460810361 )
J. Med. Internet Res. - Mining online social network data for biomedical research: a comparison of clinicians' and patients' perceptions about amyotrophic lateral sclerosis treatments. ( 0,539703624171124 )
Int J Med Robot - Computer-aided parachute guiding system for closed reduction of diaphyseal fractures. ( 0,537705228199564 )
Comput Methods Programs Biomed - A therapy parameter-based model for predicting blood glucose concentrations in patients with type 1 diabetes. ( 0,536162900720945 )
Comput Methods Programs Biomed - Describing the effectiveness of immunosuppression drugs and apheresis in the treatment of transplant patients. ( 0,535922706517303 )
IEEE Trans Neural Netw Learn Syst - Finite-Horizon Approximate Optimal Guaranteed Cost Control of Uncertain Nonlinear Systems With Application to Mars Entry Guidance. ( 0,535831679305348 )
J. Med. Internet Res. - An Internet-based intervention to promote mental fitness for mildly depressed adults: randomized controlled trial. ( 0,535231063926446 )
Comput. Biol. Med. - Density-based Monte Carlo filter and its applications in nonlinear stochastic differential equation models. ( 0,532264683924695 )
Comput. Biol. Med. - epiModel: a system to build automatically systems of differential equations of compartmental type-epidemiological models. ( 0,531854626608581 )
Med Decis Making - Treatment evolution and new standards of care: implications for cost-effectiveness analysis. ( 0,531171741251181 )
J. Med. Internet Res. - Cost-utility and cost-effectiveness of internet-based treatment for adults with depressive symptoms: randomized trial. ( 0,530062385069618 )
IEEE Trans Image Process - Additive log-logistic model for networked video quality assessment. ( 0,52949756340901 )
Comput Math Methods Med - Numerical stability of partitioned approach in fluid-structure interaction for a deformable thin-walled vessel. ( 0,529122147447411 )
J Clin Monit Comput - Simulating physiological interactions in a hybrid system of mathematical models. ( 0,528630065992637 )
IEEE Trans Image Process - Multi-Wiener SURE-LET deconvolution. ( 0,528120582277171 )
Int J Neural Syst - Multiple oscillatory states in models of collective neuronal dynamics. ( 0,527381701693085 )
J. Med. Internet Res. - Internet-based cognitive behavioral therapy for patients with chronic somatic conditions: a meta-analytic review. ( 0,526776082117065 )
IEEE Trans Image Process - Rate-distortion analysis of dead-zone plus uniform threshold scalar quantization and its application--part I: fundamental theory. ( 0,525745257452574 )
Wiley Interdiscip Rev Syst Biol Med - Influenza A virus infection kinetics: quantitative data and models. ( 0,524229741852078 )
J Chem Inf Model - Full and partial agonism of ionotropic glutamate receptors indicated by molecular dynamics simulations. ( 0,523824310755286 )
J Biomed Inform - Avatar-based simulation in the evaluation of diagnosis and management of mental health disorders in primary care. ( 0,523236997716175 )
J Telemed Telecare - Email reminders as a self-management tool in depression: a needs assessment to determine patients' interests and preferences. ( 0,520774692297849 )
Comput Math Methods Med - Uncertainty quantification in simulations of epidemics using polynomial chaos. ( 0,520466024598985 )
Comput Math Methods Med - Modeling innate immune response to early Mycobacterium infection. ( 0,520086939810999 )
Comput Math Methods Med - A meshfree method for simulating myocardial electrical activity. ( 0,519516413827513 )
Comput Math Methods Med - Spongiosa primary development: a biochemical hypothesis by Turing patterns formations. ( 0,518963637081489 )
Med Biol Eng Comput - Characterisation of the iterative integral parameter identification method. ( 0,518951623450337 )
J. Comput. Biol. - An Exact Algorithm to Compute the Double-Cut-and-Join Distance for Genomes with Duplicate Genes. ( 0,518123966198989 )
Comput Biol Chem - Stochastic synchronization of interacting pathways in testosterone model. ( 0,518122830116029 )
Wiley Interdiscip Rev Syst Biol Med - A conceptual framework for computational models of Achilles tendon homeostasis. ( 0,517711066302441 )
Med Biol Eng Comput - Assessing the effectiveness of robot facilitated neurorehabilitation for relearning motor skills following a stroke. ( 0,517527735652831 )
Med Decis Making - Do clinical psychologists extend the bereavement exclusion for major depression to other stressful life events? ( 0,517382346071489 )