Comput Math Methods Med - On the stability of lung parenchymal lesions with applications to early pneumothorax diagnosis.

Tópicos

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Resumo

Spontaneous pneumothorax, a prevalent medical challenge in most trauma cases, is a form of sudden lung collapse closely associated with risk factors such as lung cancer and emphysema. Our work seeks to explore and quantify the currently unknown pathological factors underlying lesion rupture in pneumothorax through biomechanical modeling. We hypothesized that lesion instability is closely associated with elastodynamic strain of the pleural membrane from pulsatile air flow and collagen-elastin dynamics. Based on the principles of continuum mechanics and fluid-structure interaction, our proposed model coupled isotropic tissue deformation with pressure from pulsatile air motion and the pleural fluid. Next, we derived mathematical instability criteria for our ordinary differential equation system and then translated these mathematical instabilities to physically relevant structural instabilities via the incorporation of a finite energy limiter. The introduction of novel biomechanical descriptions for collagen-elastin dynamics allowed us to demonstrate that changes in the protein structure can lead to a transition from stable to unstable domains in the material parameter space for a general lesion. This result allowed us to create a novel streamlined algorithm for detecting material instabilities in transient lung CT scan data via analyzing deformations in a local tissue boundary.

Resumo Limpo

spontan pneumothorax preval medic challeng trauma case form sudden lung collaps close associ risk factor lung cancer emphysema work seek explor quantifi current unknown patholog factor under lesion ruptur pneumothorax biomechan model hypothes lesion instabl close associ elastodynam strain pleural membran pulsatil air flow collagenelastin dynam base principl continuum mechan fluidstructur interact propos model coupl isotrop tissu deform pressur pulsatil air motion pleural fluid next deriv mathemat instabl criteria ordinari differenti equat system translat mathemat instabl physic relev structur instabl via incorpor finit energi limit introduct novel biomechan descript collagenelastin dynam allow us demonstr chang protein structur can lead transit stabl unstabl domain materi paramet space general lesion result allow us creat novel streamlin algorithm detect materi instabl transient lung ct scan data via analyz deform local tissu boundari

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