Comput Math Methods Med - Exploratory bioinformatics study of lncRNAs in Alzheimer's disease mRNA sequences with application to drug development.

Tópicos

{ measur(2081) correl(1212) valu(896) }
{ gene(2352) biolog(1181) express(1162) }
{ sequenc(1873) structur(1644) protein(1328) }
{ studi(2440) review(1878) systemat(933) }
{ studi(1119) effect(1106) posit(819) }
{ age(1611) year(1155) adult(843) }
{ cancer(2502) breast(956) screen(824) }
{ drug(1928) target(777) effect(648) }
{ compound(1573) activ(1297) structur(1058) }
{ model(2220) cell(1177) simul(1124) }
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{ import(1318) role(1303) understand(862) }
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{ use(976) code(926) identifi(902) }
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{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ analysi(2126) use(1163) compon(1037) }
{ health(1844) social(1437) communiti(874) }
{ structur(1116) can(940) graph(676) }
{ use(1733) differ(960) four(931) }
{ survey(1388) particip(1329) question(1065) }
{ decis(3086) make(1611) patient(1517) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1969) cluster(1462) data(1082) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

Long noncoding RNA (lncRNA) within mRNA sequences of Alzheimer's disease genes, namely, APP, APOE, PSEN1, and PSEN2, has been analyzed using fractal dimension (FD) computation and correlation analysis. We examined lncRNA by comparing mRNA FD to corresponding coding DNA sequences (CDSs) FD. APP, APOE, and PSEN1 CDSs select slightly higher FDs compared to the mRNA, while PSEN2 CDSs FDs are lower. The correlation coefficient for these sequences is 0.969. A comparative study of differentially expressed MAPK signaling pathway lncRNAs in pancreatic cancer cells shows a correlation of 0.771. Selection of higher FD CDSs could indicate interaction of Alzheimer's gene products APP, APOE, and PSEN1. Including hypocretin sequences (where all CDSs have higher fractal dimensions than mRNA) in the APP, APOE, and PSEN1 sequence analyses improves correlation, but the inclusion of erythropoietin (where all CDSs have higher FD than mRNA) would suppress correlation, suggesting that HCRT, a hypothalamus neurotransmitter related to the wake/sleep cycle, might be better when compared to EPO, a glycoprotein hormone, for targeting Alzheimer's disease drug development. Fractal dimension and entropy correlation have provided supporting evidence, consistent with evolutionary studies, for using a zebrafish model together with a mouse model, in HCRT drug development.

Resumo Limpo

long noncod rna lncrna within mrna sequenc alzheim diseas gene name app apo psen psen analyz use fractal dimens fd comput correl analysi examin lncrna compar mrna fd correspond code dna sequenc cdss fd app apo psen cdss select slight higher fds compar mrna psen cdss fds lower correl coeffici sequenc compar studi differenti express mapk signal pathway lncrnas pancreat cancer cell show correl select higher fd cdss indic interact alzheim gene product app apo psen includ hypocretin sequenc cdss higher fractal dimens mrna app apo psen sequenc analys improv correl inclus erythropoietin cdss higher fd mrna suppress correl suggest hcrt hypothalamus neurotransmitt relat wakesleep cycl might better compar epo glycoprotein hormon target alzheim diseas drug develop fractal dimens entropi correl provid support evid consist evolutionari studi use zebrafish model togeth mous model hcrt drug develop

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