Comput Math Methods Med - Superficial collagen fibril modulus and pericellular fixed charge density modulate chondrocyte volumetric behaviour in early osteoarthritis.

Tópicos

{ model(2220) cell(1177) simul(1124) }
{ chang(1828) time(1643) increas(1301) }
{ blood(1257) pressur(1144) flow(957) }
{ studi(1119) effect(1106) posit(819) }
{ model(3480) simul(1196) paramet(876) }
{ structur(1116) can(940) graph(676) }
{ activ(1138) subject(705) human(624) }
{ algorithm(1844) comput(1787) effici(935) }
{ spatial(1525) area(1432) region(1030) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1219) similar(1157) match(930) }
{ problem(2511) optim(1539) algorithm(950) }
{ imag(2830) propos(1344) filter(1198) }
{ design(1359) user(1324) use(1319) }
{ perform(999) metric(946) measur(919) }
{ research(1085) discuss(1038) issu(1018) }
{ perform(1367) use(1326) method(1137) }
{ data(2317) use(1299) case(1017) }
{ cancer(2502) breast(956) screen(824) }
{ implement(1333) system(1263) develop(1122) }
{ method(1969) cluster(1462) data(1082) }
{ model(3404) distribut(989) bayesian(671) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ data(1737) use(1416) pattern(1282) }
{ inform(2794) health(2639) internet(1427) }
{ system(1976) rule(880) can(841) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
{ sequenc(1873) structur(1644) protein(1328) }
{ featur(3375) classif(2383) classifi(1994) }
{ network(2748) neural(1063) input(814) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ take(945) account(800) differ(722) }
{ studi(2440) review(1878) systemat(933) }
{ motion(1329) object(1292) video(1091) }
{ assess(1506) score(1403) qualiti(1306) }
{ treatment(1704) effect(941) patient(846) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ framework(1458) process(801) describ(734) }
{ error(1145) method(1030) estim(1020) }
{ learn(2355) train(1041) set(1003) }
{ concept(1167) ontolog(924) domain(897) }
{ clinic(1479) use(1117) guidelin(835) }
{ extract(1171) text(1153) clinic(932) }
{ method(1557) propos(1049) approach(1037) }
{ data(1714) softwar(1251) tool(1186) }
{ control(1307) perform(991) simul(935) }
{ care(1570) inform(1187) nurs(1089) }
{ general(901) number(790) one(736) }
{ method(984) reconstruct(947) comput(926) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ case(1353) use(1143) diagnosi(1136) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ studi(1410) differ(1259) use(1210) }
{ risk(3053) factor(974) diseas(938) }
{ system(1050) medic(1026) inform(1018) }
{ import(1318) role(1303) understand(862) }
{ model(2341) predict(2261) use(1141) }
{ visual(1396) interact(850) tool(830) }
{ compound(1573) activ(1297) structur(1058) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ state(1844) use(1261) util(961) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
{ gene(2352) biolog(1181) express(1162) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ analysi(2126) use(1163) compon(1037) }
{ health(1844) social(1437) communiti(874) }
{ high(1669) rate(1365) level(1280) }
{ use(976) code(926) identifi(902) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ result(1111) use(1088) new(759) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ decis(3086) make(1611) patient(1517) }
{ process(1125) use(805) approach(778) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

The aim of this study was to investigate if the experimentally detected altered chondrocyte volumetric behavior in early osteoarthritis can be explained by changes in the extracellular and pericellular matrix properties of cartilage. Based on our own experimental tests and the literature, the structural and mechanical parameters for normal and osteoarthritic cartilage were implemented into a multiscale fibril-reinforced poroelastic swelling model. Model simulations were compared with experimentally observed cell volume changes in mechanically loaded cartilage, obtained from anterior cruciate ligament transected rabbit knees. We found that the cell volume increased by 7% in the osteoarthritic cartilage model following mechanical loading of the tissue. In contrast, the cell volume decreased by 4% in normal cartilage model. These findings were consistent with the experimental results. Increased local transversal tissue strain due to the reduced collagen fibril stiffness accompanied with the reduced fixed charge density of the pericellular matrix could increase the cell volume up to 12%. These findings suggest that the increase in the cell volume in mechanically loaded osteoarthritic cartilage is primarily explained by the reduction in the pericellular fixed charge density, while the superficial collagen fibril stiffness is suggested to contribute secondarily to the cell volume behavior.

Resumo Limpo

aim studi investig experiment detect alter chondrocyt volumetr behavior earli osteoarthr can explain chang extracellular pericellular matrix properti cartilag base experiment test literatur structur mechan paramet normal osteoarthrit cartilag implement multiscal fibrilreinforc poroelast swell model model simul compar experiment observ cell volum chang mechan load cartilag obtain anterior cruciat ligament transect rabbit knee found cell volum increas osteoarthrit cartilag model follow mechan load tissu contrast cell volum decreas normal cartilag model find consist experiment result increas local transvers tissu strain due reduc collagen fibril stiff accompani reduc fix charg densiti pericellular matrix increas cell volum find suggest increas cell volum mechan load osteoarthrit cartilag primarili explain reduct pericellular fix charg densiti superfici collagen fibril stiff suggest contribut secondarili cell volum behavior

Resumos Similares

Med Biol Eng Comput - The remodeling of alveolar bone supporting the mandibular first molar with different levels of periodontal attachment. ( 0,875116102240386 )
Med Biol Eng Comput - Temporal evolution of skeletal regenerated tissue: what can mechanical investigation add to biological? ( 0,866228882660877 )
Med Biol Eng Comput - Influence of ischemic core muscle fibers on surface depolarization potentials in superfused cardiac tissue preparations: a simulation study. ( 0,866168583979479 )
Int J Comput Assist Radiol Surg - Multi-scale model for investigating the electrical properties and mechanical properties of liver tissue undergoing ablation. ( 0,857639972534741 )
Comput. Biol. Med. - Computational studies on strain transmission from a collagen gel construct to a cell and its internal cytoskeletal filaments. ( 0,850817625048519 )
Med Biol Eng Comput - Effects of simulated injury on the anteroinferior glenohumeral capsule. ( 0,850732197123978 )
Med Biol Eng Comput - Sensitivity studies of pediatric material properties on juvenile lumbar spine responses using finite element analysis. ( 0,848647036234126 )
Comput. Biol. Med. - Biological-data-based finite-element stress analysis of mandibular bone with implant-supported overdenture. ( 0,848147032324102 )
Med Biol Eng Comput - Change of mechanical vertebrae properties due to progressive osteoporosis: combined biomechanical and finite-element analysis within a rat model. ( 0,844240642949184 )
Comput Math Methods Med - A finite element study of micropipette aspiration of single cells: effect of compressibility. ( 0,843171097702003 )
Comput. Biol. Med. - Finite element modelling of diseased carotid bifurcations generated from in vivo computerised tomographic angiography. ( 0,842939718388519 )
Comput Math Methods Med - Morphological measurement of living cells in methanol with digital holographic microscopy. ( 0,842435269095406 )
Comput Math Methods Med - Altered knee joint mechanics in simple compression associated with early cartilage degeneration. ( 0,841775589455094 )
Med Biol Eng Comput - Modeling and experimental methods to predict oxygen distribution in bone defects following cell transplantation. ( 0,840292291871487 )
Comput Math Methods Med - A review of the combination of experimental measurements and fibril-reinforced modeling for investigation of articular cartilage and chondrocyte response to loading. ( 0,83633238948076 )
Med Biol Eng Comput - Mechanical and microarchitectural analyses of cancellous bone through experiment and computer simulation. ( 0,834734658545389 )
Comput Math Methods Med - Fluid structural analysis of human cerebral aneurysm using their own wall mechanical properties. ( 0,832972418719029 )
Med Biol Eng Comput - Effect of heterogeneities in the cellular microstructure on propagation of the cardiac action potential. ( 0,829784147761814 )
Comput Methods Programs Biomed - Experiment and hydro-mechanical coupling simulation study on the human periodontal ligament. ( 0,829243289254191 )
Comput Methods Programs Biomed - A phenomenological mathematical model of the articular cartilage damage. ( 0,827883456392783 )
Med Biol Eng Comput - Multi-scale study of nanoparticle transport and deposition in tissues during an injection process. ( 0,821763900760627 )
Med Biol Eng Comput - Sensitivity of patient-specific vertebral finite element model from low dose imaging to material properties and loading conditions. ( 0,818183489425992 )
Comput. Biol. Med. - Biomechanical simulation of various surface roughnesses and geometric designs on an immediately loaded dental implant. ( 0,81711480337267 )
J Med Syst - Post-operative assessment of an implant fixation in anterior cruciate ligament reconstructive surgery. ( 0,815685232444024 )
Comput Methods Programs Biomed - Subject-specific finite element simulation of the human femur considering inhomogeneous material properties: a straightforward method and convergence study. ( 0,814970243267296 )
Med Biol Eng Comput - Clinically oriented real-time monitoring of the individual's risk for deep tissue injury. ( 0,814272402441069 )
Med Biol Eng Comput - 3D network model of NO transport in tissue. ( 0,812390122168182 )
Med Biol Eng Comput - 3D finite element analysis on esthetic indirect dental restorations under thermal and mechanical loading. ( 0,810119145101445 )
Med Biol Eng Comput - Calibration of the mechanical properties in a finite element model of a lumbar vertebra under dynamic compression up to failure. ( 0,80898260494942 )
Comput Math Methods Med - Recent advances in computational mechanics of the human knee joint. ( 0,80849468705237 )
Int J Comput Assist Radiol Surg - Bivariate optimization of orthodontic mini-implant thread height and pitch. ( 0,807717433702598 )
Int J Comput Assist Radiol Surg - Surgical stent planning: simulation parameter study for models based on DICOM standards. ( 0,805736425190395 )
Med Biol Eng Comput - Effects of skin wrinkles, age and wetness on mechanical loads in the stratum corneum as related to skin lesions. ( 0,805663139535125 )
Med Biol Eng Comput - A new method to include the gravitational forces in a finite element model of the scoliotic spine. ( 0,80476091459173 )
Med Biol Eng Comput - A three-dimensional finite element model of the cervical spine: an investigation of whiplash injury. ( 0,804164167449769 )
Med Biol Eng Comput - Biomechanical characterisation of fresh and cadaverous human small intestine: applications for abdominal trauma. ( 0,795817044776262 )
Med Biol Eng Comput - Validation efforts and flexibilities of an eight-year-old human juvenile lumbar spine using a three-dimensional finite element model. ( 0,791157363959955 )
Med Biol Eng Comput - Continuous flow left ventricular pump support and its effect on regional left ventricular wall stress: finite element analysis study. ( 0,790743444926808 )
Comput Math Methods Med - Comparative evaluation of osseointegrated dental implants based on platform-switching concept: influence of diameter, length, thread shape, and in-bone positioning depth on stress-based performance. ( 0,790475372406296 )
IEEE J Biomed Health Inform - Skin Temperature Prediction in Lower Limb Prostheses. ( 0,788763032086644 )
Comput Methods Programs Biomed - Prediction of coronary plaque location on arteries having myocardial bridge, using finite element models. ( 0,788713433491619 )
Comput Math Methods Med - Contribution to the determination of in vivo mechanical characteristics of human skin by indentation test. ( 0,784949573751928 )
Med Biol Eng Comput - In-silico modeling of atrial repolarization in normal and atrial fibrillation remodeled state. ( 0,784211861186419 )
J. Comput. Biol. - Cytopede: a three-dimensional tool for modeling cell motility on a flat surface. ( 0,783276889650179 )
Comput. Biol. Med. - Application of an anatomically-detailed finite element thorax model to investigate pediatric cardiopulmonary resuscitation techniques on hard bed. ( 0,783127773519716 )
Comput. Biol. Med. - Protein transport in the connecting cilium of a photoreceptor cell: modeling the effects of bidirectional protein transitions between the diffusion-driven and motor-driven kinetic states. ( 0,783001660100777 )
Med Biol Eng Comput - A nonlinear finite element simulation of balloon expandable stent for assessment of plaque vulnerability inside a stenotic artery. ( 0,781242968838756 )
Med Biol Eng Comput - Finite element modeling of mitral leaflet tissue using a layered shell approximation. ( 0,778460212639951 )
Med Biol Eng Comput - Backflow length predictions during flow-controlled infusions using a nonlinear biphasic finite element model. ( 0,775250202763225 )
Int J Med Robot - A physics-based algorithm for real-time simulation of electrosurgery procedures in minimally invasive surgery. ( 0,774907749881593 )
Med Biol Eng Comput - Strain rate-dependent viscohyperelastic constitutive modeling of bovine liver tissue. ( 0,774218659613615 )
Comput Methods Programs Biomed - Growth plate stress distribution implications during bone development: a simple framework computational approach. ( 0,772167422813266 )
Comput Methods Programs Biomed - Computational analysis of cartilage implants based on an interpenetrated polymer network for tissue repairing. ( 0,771768330123012 )
Int J Comput Assist Radiol Surg - Real-time simulation of the nonlinear visco-elastic deformations of soft tissues. ( 0,770612916734977 )
Med Biol Eng Comput - Biomechanical modeling of brace treatment of scoliosis: effects of gravitational loads. ( 0,769245271061699 )
Med Biol Eng Comput - Characterization of cellular elastic modulus using structure based double layer model. ( 0,769107415923461 )
Med Biol Eng Comput - Estimation of the retainer height biomechanical contribution in posterior resin-bonded fixed partial dentures: a structural-thermal coupled finite element analysis. ( 0,768444629821108 )
Comput Math Methods Med - Quantitative imaging of young's modulus of soft tissues from ultrasound water jet indentation: a finite element study. ( 0,767547140781699 )
Artif Intell Med - Relationship between preparation of cells for therapy and cell quality using artificial neural network analysis. ( 0,76703948415994 )
Med Biol Eng Comput - Biomechanical analysis of the effects of medial meniscectomy on degenerative osteoarthritis. ( 0,765378057843685 )
Med Biol Eng Comput - Modeling and analysis of coagulated liver tissue and its interaction with a scalpel blade. ( 0,764785191143729 )
Med Biol Eng Comput - Finite element analysis of the influence of loading rate on a model of the full lumbar spine under dynamic loading conditions. ( 0,763699762464897 )
Med Biol Eng Comput - Biomechanical analysis of traumatic mesenteric avulsion. ( 0,762631122093249 )
Med Biol Eng Comput - Patient-specific finite element modeling of the Cardiokinetix Parachute(?) device: effects on left ventricular wall stress and function. ( 0,762537005862649 )
Comput Math Methods Med - The effect of inhibitory neuron on the evolution model of higher-order coupling neural oscillator population. ( 0,760740117085521 )
Comput. Biol. Med. - Prediction of stress shielding around an orthopedic screw: using stress and strain energy density as mechanical stimuli. ( 0,760037621193019 )
Med Biol Eng Comput - Biomechanics of thoracolumbar junction vertebral fractures from various kinematic conditions. ( 0,758281065889826 )
Comput Methods Programs Biomed - Monte Carlo method for photon heating using temperature-dependent optical properties. ( 0,757427494572228 )
Med Biol Eng Comput - Computer simulation of three-dimensional plaque formation and progression in the carotid artery. ( 0,757260961038536 )
Comput. Biol. Med. - A computational study of the respiratory airflow characteristics in normal and obstructed human airways. ( 0,75669540683919 )
Comput Math Methods Med - The influence of the specimen shape and loading conditions on the parameter identification of a viscoelastic brain model. ( 0,754029197309452 )
Med Biol Eng Comput - Mathematical modeling of stem cell proliferation. ( 0,75268305755334 )
J Clin Monit Comput - Monitoring CO2 in shock states. ( 0,750782459333085 )
Med Biol Eng Comput - Influence of heterogeneous and anisotropic tissue conductivity on electric field distribution in deep brain stimulation. ( 0,749962875686185 )
Med Biol Eng Comput - Comparison of the influences of structural characteristics on bulk mechanical behaviour: experimental study using a bone surrogate. ( 0,7476428214428 )
Comput. Biol. Med. - A computational pipeline for quantification of mouse myocardial stiffness parameters. ( 0,746669250566059 )
Comput Methods Programs Biomed - Modelling of mandible bone properties in the numerical analysis of oral implant biomechanics. ( 0,74654329609181 )
Med Biol Eng Comput - Can common adhesion molecules and microtopography affect cellular elasticity? A combined atomic force microscopy and optical study. ( 0,746395285626144 )
Med Biol Eng Comput - Biomechanical comparison of fusionless growth modulation corrective techniques in pediatric scoliosis. ( 0,7456954820076 )
Comput Math Methods Med - Dynamics of posttranslational modifications of p53. ( 0,74354425781417 )
Comput Math Methods Med - Study of tumor growth under hyperthermia condition. ( 0,74159986134888 )
Comput Methods Programs Biomed - 3D reconstruction of TMJ after resection of the cyst and the stress-strain analyses. ( 0,740932476831265 )
J Med Syst - Functional and mechanical evaluation of nerve stretch injury. ( 0,740121896842291 )
Comput Math Methods Med - Circadian models of serum potassium, sodium, and calcium concentrations in healthy individuals and their application to cardiac electrophysiology simulations at individual level. ( 0,740016460793203 )
Med Biol Eng Comput - Generating anatomical models of the heart and the aorta from medical images for personalized physiological simulations. ( 0,737012837609653 )
Wiley Interdiscip Rev Syst Biol Med - Integrative approaches for modeling regulation and function of the respiratory system. ( 0,736669874299854 )
Comput Math Methods Med - A literature review of the numerical analysis of abdominal aortic aneurysms treated with endovascular stent grafts. ( 0,736058065101767 )
IEEE Trans Vis Comput Graph - A Hexahedral Multigrid Approach for Simulating Cuts in Deformable Objects. ( 0,736017021618728 )
Wiley Interdiscip Rev Syst Biol Med - Vascular tissue engineering: from in vitro to in situ. ( 0,732524948223957 )
Comput Methods Programs Biomed - Determination of nonlinear fibre-reinforced biphasic poroviscoelastic constitutive parameters of articular cartilage using stress relaxation indentation testing and an optimizing finite element analysis. ( 0,731976516382673 )
Med Biol Eng Comput - Unsteady wall shear stress analysis from image-based computational fluid dynamic aneurysm models under Newtonian and Casson rheological models. ( 0,730117085573688 )
Med Biol Eng Comput - Comparison of four mathematical models to analyze indicator-dilution curves in the coronary circulation. ( 0,729710525664553 )
Comput Math Methods Med - Modeling the relationship between fluorodeoxyglucose uptake and tumor radioresistance as a function of the tumor microenvironment. ( 0,728910059662123 )
Comput Math Methods Med - Excitation-contraction coupling between human atrial myocytes with fibroblasts and stretch activated channel current: a simulation study. ( 0,728622945365066 )
Comput Math Methods Med - A computational modeling approach for investigating soft tissue balancing in bicruciate retaining knee arthroplasty. ( 0,728117672990004 )
Comput. Biol. Med. - Tooth fracture risk analysis based on a new finite element dental structure models using micro-CT data. ( 0,727150147694075 )
Comput. Biol. Med. - Modeling of tumor growth undergoing virotherapy. ( 0,724551588674193 )
Wiley Interdiscip Rev Syst Biol Med - A systems biology approach to synovial joint lubrication in health, injury, and disease. ( 0,724368499319682 )
Comput Methods Programs Biomed - An FDTD-based computer simulation platform for shock wave propagation in electrohydraulic lithotripsy. ( 0,72360863684421 )
Comput Methods Programs Biomed - Optimal bone density distributions: numerical analysis of the osteocyte spatial influence in bone remodeling. ( 0,723486899467189 )