Comput Math Methods Med - Group factor analysis for Alzheimer's disease.

Tópicos

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Resumo

For any neuroimaging study in an institute, brain images are normally acquired from healthy controls and patients using a single track of protocol. Traditionally, the factor analysis procedure analyzes image data for healthy controls and patients either together or separately. The former unifies the factor pattern across subjects and the latter deals with measurement errors individually. This paper proposes a group factor analysis model for neuroimaging applications by assigning separate factor patterns to control and patient groups. The clinical diagnosis information is used for categorizing subjects into groups in the analysis procedure. The proposed method allows different groups of subjects to share a common covariance matrix of measurement errors. The empirical results show that the proposed method provides more reasonable factor scores and patterns and is more suitable for medical research based on image data as compared with the conventional factor analysis model.

Resumo Limpo

neuroimag studi institut brain imag normal acquir healthi control patient use singl track protocol tradit factor analysi procedur analyz imag data healthi control patient either togeth separ former unifi factor pattern across subject latter deal measur error individu paper propos group factor analysi model neuroimag applic assign separ factor pattern control patient group clinic diagnosi inform use categor subject group analysi procedur propos method allow differ group subject share common covari matrix measur error empir result show propos method provid reason factor score pattern suitabl medic research base imag data compar convent factor analysi model

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