Comput Math Methods Med - Attenuation correction for small animal PET images: a comparison of two methods.

Tópicos

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Resumo

In order to extract quantitative parameters from PET images, several physical effects such as photon attenuation, scatter, and partial volume must be taken into account. The main objectives of this work were the evaluation of photon attenuation in small animals and the implementation of two attenuation correction methods based on X-rays CT and segmentation of emission images. The accuracy of the first method with respect to the beam hardening effect was investigated by using Monte Carlo simulations. Mouse- and rat-sized phantoms were acquired in order to evaluate attenuation correction in terms of counts increment and recovery of uniform activity concentration. Both methods were applied to mice and rat images acquired with several radiotracers such as(18)F-FDG, (11)C-acetate, (68)Ga-chloride, and (18)F-NaF. The accuracy of the proposed methods was evaluated in heart and tumour tissues using (18)F-FDG images and in liver, kidney, and spinal column tissues using (11)C-acetate, (68)Ga-chloride, and (18)F-NaF images, respectively. In vivo results from animal studies show that, except for bone scans, differences between the proposed methods were about 10% in rats and 3% in mice. In conclusion, both methods provide equivalent results; however, the segmentation-based approach has several advantages being less time consuming and simple to implement.

Resumo Limpo

order extract quantit paramet pet imag sever physic effect photon attenu scatter partial volum must taken account main object work evalu photon attenu small anim implement two attenu correct method base xray ct segment emiss imag accuraci first method respect beam harden effect investig use mont carlo simul mous ratsiz phantom acquir order evalu attenu correct term count increment recoveri uniform activ concentr method appli mice rat imag acquir sever radiotrac asffdg cacet gachlorid fnaf accuraci propos method evalu heart tumour tissu use ffdg imag liver kidney spinal column tissu use cacet gachlorid fnaf imag respect vivo result anim studi show except bone scan differ propos method rat mice conclus method provid equival result howev segmentationbas approach sever advantag less time consum simpl implement

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