Comput Math Methods Med - Computational fluid dynamics simulations of contrast agent bolus dispersion in a coronary bifurcation: impact on MRI-based quantification of myocardial perfusion.


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Contrast-enhanced first-pass magnetic resonance imaging (MRI) in combination with a tracer kinetic model, for example, MMID4, can be used to determine myocardial blood flow (MBF) and myocardial perfusion reserve (MPR). Typically, the arterial input function (AIF) required for this methodology is estimated from the left ventricle (LV). Dispersion of the contrast agent bolus might occur between the LV and the myocardial tissue. Negligence of bolus dispersion could cause an error in MBF determination. The aim of this study was to investigate the influence of bolus dispersion in a simplified coronary bifurcation geometry including one healthy and one stenotic branch on the quantification of MBF and MPR. Computational fluid dynamics (CFD) simulations were combined with MMID4. Different inlet boundary conditions describing pulsatile and constant flows for rest and hyperemia and differing outflow conditions have been investigated. In the bifurcation region, the increase of the dispersion was smaller than inside the straight vessels. A systematic underestimation of MBF values up to -16.1% for pulsatile flow and an overestimation of MPR up to 7.5% were found. It was shown that, under the conditions considered in this study, bolus dispersion can significantly influence the results of quantitative myocardial MR-perfusion measurements.

Resumo Limpo

contrastenhanc firstpass magnet reson imag mri combin tracer kinet model exampl mmid can use determin myocardi blood flow mbf myocardi perfus reserv mpr typic arteri input function aif requir methodolog estim left ventricl lv dispers contrast agent bolus might occur lv myocardi tissu neglig bolus dispers caus error mbf determin aim studi investig influenc bolus dispers simplifi coronari bifurc geometri includ one healthi one stenot branch quantif mbf mpr comput fluid dynam cfd simul combin mmid differ inlet boundari condit describ pulsatil constant flow rest hyperemia differ outflow condit investig bifurc region increas dispers smaller insid straight vessel systemat underestim mbf valu pulsatil flow overestim mpr found shown condit consid studi bolus dispers can signific influenc result quantit myocardi mrperfus measur

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