Comput Math Methods Med - Quantitative measurements in 3-dimensional datasets of mouse lymph nodes resolve organ-wide functional dependencies.

Tópicos

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Resumo

Deep tissue imaging has become state of the art in biology, but now the problem is to quantify spatial information in a global, organ-wide context. Although access to the raw data is no longer a limitation, the computational tools to extract biologically useful information out of these large data sets is still catching up. In many cases, to understand the mechanism behind a biological process, where molecules or cells interact with each other, it is mandatory to know their mutual positions. We illustrate this principle here with the immune system. Although the general functions of lymph nodes as immune sentinels are well described, many cellular and molecular details governing the interactions of lymphocytes and dendritic cells remain unclear to date and prevent an in-depth mechanistic understanding of the immune system. We imaged ex vivo lymph nodes isolated from both wild-type and transgenic mice lacking key factors for dendritic cell positioning and used software written in MATLAB to determine the spatial distances between the dendritic cells and the internal high endothelial vascular network. This allowed us to quantify the spatial localization of the dendritic cells in the lymph node, which is a critical parameter determining the effectiveness of an adaptive immune response.

Resumo Limpo

deep tissu imag becom state art biolog now problem quantifi spatial inform global organwid context although access raw data longer limit comput tool extract biolog use inform larg data set still catch mani case understand mechan behind biolog process molecul cell interact mandatori know mutual posit illustr principl immun system although general function lymph node immun sentinel well describ mani cellular molecular detail govern interact lymphocyt dendrit cell remain unclear date prevent indepth mechanist understand immun system imag ex vivo lymph node isol wildtyp transgen mice lack key factor dendrit cell posit use softwar written matlab determin spatial distanc dendrit cell intern high endotheli vascular network allow us quantifi spatial local dendrit cell lymph node critic paramet determin effect adapt immun respons

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