Comput Math Methods Med - Understanding immunology via engineering design: the role of mathematical prototyping.

Tópicos

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Resumo

A major challenge in immunology is how to translate data into knowledge given the inherent complexity and dynamics of human physiology. Both the physiology and engineering communities have rich histories in applying computational approaches to translate data obtained from complex systems into knowledge of system behavior. However, there are some differences in how disciplines approach problems. By referring to mathematical models as mathematical prototypes, we aim to highlight aspects related to the process (i.e., prototyping) rather than the product (i.e., the model). The objective of this paper is to review how two related engineering concepts, specifically prototyping and "fitness for use," can be applied to overcome the pressing challenge in translating data into improved knowledge of basic immunology that can be used to improve therapies for disease. These concepts are illustrated using two immunology-related examples. The prototypes presented focus on the beta cell mass at the onset of type 1 diabetes and the dynamics of dendritic cells in the lung. This paper is intended to illustrate some of the nuances associated with applying mathematical modeling to improve understanding of the dynamics of disease progression in humans.

Resumo Limpo

major challeng immunolog translat data knowledg given inher complex dynam human physiolog physiolog engin communiti rich histori appli comput approach translat data obtain complex system knowledg system behavior howev differ disciplin approach problem refer mathemat model mathemat prototyp aim highlight aspect relat process ie prototyp rather product ie model object paper review two relat engin concept specif prototyp fit use can appli overcom press challeng translat data improv knowledg basic immunolog can use improv therapi diseas concept illustr use two immunologyrel exampl prototyp present focus beta cell mass onset type diabet dynam dendrit cell lung paper intend illustr nuanc associ appli mathemat model improv understand dynam diseas progress human

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