Comput Math Methods Med - A mathematical model of immune-system-melanoma competition.

Tópicos

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Resumo

We present a mathematical model developed to reproduce the immune response entitled with the combined administration of activated OT1 cytotoxic T lymphocytes (CTLs) and Anti-CD137 monoclonal antibodies. The treatment is directed against melanoma in B16 OVA mouse models exposed to a specific immunotherapy strategy. We model two compartments: the injection point compartment where the treatment is administered and the skin compartment where melanoma tumor cells proliferate. To model the migration of OT1 CTLs and antibodies from the injection to the skin compartment, we use delay differential equations (DDEs). The outcomes of the mathematical model are in good agreement with the in vivo results. Moreover, sensitivity analysis of the mathematical model underlines the key role of OT1 CTLs and suggests that a possible reduction of the number of injected antibodies should not affect substantially the treatment efficacy.

Resumo Limpo

present mathemat model develop reproduc immun respons entitl combin administr activ ot cytotox t lymphocyt ctls anticd monoclon antibodi treatment direct melanoma b ova mous model expos specif immunotherapi strategi model two compart inject point compart treatment administ skin compart melanoma tumor cell prolifer model migrat ot ctls antibodi inject skin compart use delay differenti equat ddes outcom mathemat model good agreement vivo result moreov sensit analysi mathemat model underlin key role ot ctls suggest possibl reduct number inject antibodi affect substanti treatment efficaci

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