Comput Math Methods Med - Revealing -1 programmed ribosomal frameshifting mechanisms by single-molecule techniques and computational methods.

Tópicos

{ gene(2352) biolog(1181) express(1162) }
{ cancer(2502) breast(956) screen(824) }
{ bind(1733) structur(1185) ligand(1036) }
{ activ(1138) subject(705) human(624) }
{ can(774) often(719) complex(702) }
{ algorithm(1844) comput(1787) effici(935) }
{ extract(1171) text(1153) clinic(932) }
{ method(1557) propos(1049) approach(1037) }
{ research(1085) discuss(1038) issu(1018) }
{ import(1318) role(1303) understand(862) }
{ model(3480) simul(1196) paramet(876) }
{ data(1737) use(1416) pattern(1282) }
{ imag(1057) registr(996) error(939) }
{ featur(3375) classif(2383) classifi(1994) }
{ imag(2830) propos(1344) filter(1198) }
{ take(945) account(800) differ(722) }
{ motion(1329) object(1292) video(1091) }
{ chang(1828) time(1643) increas(1301) }
{ control(1307) perform(991) simul(935) }
{ care(1570) inform(1187) nurs(1089) }
{ featur(1941) imag(1645) propos(1176) }
{ studi(1410) differ(1259) use(1210) }
{ age(1611) year(1155) adult(843) }
{ signal(2180) analysi(812) frequenc(800) }
{ group(2977) signific(1463) compar(1072) }
{ can(981) present(881) function(850) }
{ analysi(2126) use(1163) compon(1037) }
{ structur(1116) can(940) graph(676) }
{ use(976) code(926) identifi(902) }
{ implement(1333) system(1263) develop(1122) }
{ estim(2440) model(1874) function(577) }
{ process(1125) use(805) approach(778) }
{ method(2212) result(1239) propos(1039) }
{ model(3404) distribut(989) bayesian(671) }
{ imag(1947) propos(1133) code(1026) }
{ inform(2794) health(2639) internet(1427) }
{ system(1976) rule(880) can(841) }
{ measur(2081) correl(1212) valu(896) }
{ sequenc(1873) structur(1644) protein(1328) }
{ method(1219) similar(1157) match(930) }
{ network(2748) neural(1063) input(814) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ studi(2440) review(1878) systemat(933) }
{ assess(1506) score(1403) qualiti(1306) }
{ treatment(1704) effect(941) patient(846) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ framework(1458) process(801) describ(734) }
{ problem(2511) optim(1539) algorithm(950) }
{ error(1145) method(1030) estim(1020) }
{ learn(2355) train(1041) set(1003) }
{ concept(1167) ontolog(924) domain(897) }
{ clinic(1479) use(1117) guidelin(835) }
{ data(1714) softwar(1251) tool(1186) }
{ design(1359) user(1324) use(1319) }
{ model(2220) cell(1177) simul(1124) }
{ general(901) number(790) one(736) }
{ method(984) reconstruct(947) comput(926) }
{ search(2224) databas(1162) retriev(909) }
{ case(1353) use(1143) diagnosi(1136) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ risk(3053) factor(974) diseas(938) }
{ perform(999) metric(946) measur(919) }
{ system(1050) medic(1026) inform(1018) }
{ model(2341) predict(2261) use(1141) }
{ visual(1396) interact(850) tool(830) }
{ compound(1573) activ(1297) structur(1058) }
{ perform(1367) use(1326) method(1137) }
{ studi(1119) effect(1106) posit(819) }
{ blood(1257) pressur(1144) flow(957) }
{ spatial(1525) area(1432) region(1030) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ state(1844) use(1261) util(961) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ data(2317) use(1299) case(1017) }
{ medic(1828) order(1363) alert(1069) }
{ cost(1906) reduc(1198) effect(832) }
{ sampl(1606) size(1419) use(1276) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ health(1844) social(1437) communiti(874) }
{ high(1669) rate(1365) level(1280) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ result(1111) use(1088) new(759) }
{ survey(1388) particip(1329) question(1065) }
{ decis(3086) make(1611) patient(1517) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1969) cluster(1462) data(1082) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

Programmed ribosomal frameshifting (PRF) serves as an intrinsic translational regulation mechanism employed by some viruses to control the ratio between structural and enzymatic proteins. Most viral mRNAs which use PRF adapt an H-type pseudoknot to stimulate -1 PRF. The relationship between the thermodynamic stability and the frameshifting efficiency of pseudoknots has not been fully understood. Recently, single-molecule force spectroscopy has revealed that the frequency of -1 PRF correlates with the unwinding forces required for disrupting pseudoknots, and that some of the unwinding work dissipates irreversibly due to the torsional restraint of pseudoknots. Complementary to single-molecule techniques, computational modeling provides insights into global motions of the ribosome, whose structural transitions during frameshifting have not yet been elucidated in atomic detail. Taken together, recent advances in biophysical tools may help to develop antiviral therapies that target the ubiquitous -1 PRF mechanism among viruses.

Resumo Limpo

program ribosom frameshift prf serv intrins translat regul mechan employ virus control ratio structur enzymat protein viral mrnas use prf adapt htype pseudoknot stimul prf relationship thermodynam stabil frameshift effici pseudoknot fulli understood recent singlemolecul forc spectroscopi reveal frequenc prf correl unwind forc requir disrupt pseudoknot unwind work dissip irrevers due torsion restraint pseudoknot complementari singlemolecul techniqu comput model provid insight global motion ribosom whose structur transit frameshift yet elucid atom detail taken togeth recent advanc biophys tool may help develop antivir therapi target ubiquit prf mechan among virus

Resumos Similares

Comput Methods Programs Biomed - TMT-HCC: a tool for text mining the biomedical literature for hepatocellular carcinoma (HCC) biomarkers identification. ( 0,763924070772461 )
Comput Math Methods Med - Identification and functional annotation of genome-wide ER-regulated genes in breast cancer based on ChIP-Seq data. ( 0,72408082773421 )
Comput. Biol. Med. - Genome-wide identification and structure-function studies of proteases and protease inhibitors in Cicer arietinum (chickpea). ( 0,71624300263586 )
Comput Math Methods Med - Mathematical model of dynamic protein interactions regulating p53 protein stability for tumor suppression. ( 0,713756761165776 )
J Biomed Inform - Protein interaction network underpins concordant prognosis among heterogeneous breast cancer signatures. ( 0,691750825771146 )
Med Biol Eng Comput - A method for detecting significant genomic regions associated with oral squamous cell carcinoma using aCGH. ( 0,690676274574703 )
J Biomed Inform - Serum cancer biomarker discovery through analysis of gene expression data sets across multiple tumor and normal tissues. ( 0,690381942827435 )
Comput. Biol. Med. - Learning the local Bayesian network structure around the ZNF217 oncogene in breast tumours. ( 0,689587410350627 )
Brief. Bioinformatics - Deciphering oncogenic drivers: from single genes to integrated pathways. ( 0,676807995461213 )
Comput. Biol. Med. - ICP: A novel approach to predict prognosis of prostate cancer with inner-class clustering of gene expression data. ( 0,675236829668062 )
Comput Methods Programs Biomed - TC-VGC: a tumor classification system using variations in genes' correlation. ( 0,672557797364308 )
Comput Biol Chem - Revealing weak differential gene expressions and their reproducible functions associated with breast cancer metastasis. ( 0,672257246468257 )
Brief. Bioinformatics - Breast cancer classification: linking molecular mechanisms to disease prognosis. ( 0,670628280693514 )
Comput. Biol. Med. - Network-based approach reveals Y chromosome influences prostate cancer susceptibility. ( 0,66924565759916 )
Wiley Interdiscip Rev Syst Biol Med - ?-Arrestin-kinase scaffolds: turn them on or turn them off? ( 0,669024832231766 )
Comput Biol Chem - Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. ( 0,668014411867313 )
Comput. Biol. Med. - Impact of TGF-b on breast cancer from a quantitative proteomic analysis. ( 0,663221549789603 )
Wiley Interdiscip Rev Syst Biol Med - Cyclic nucleotide signaling in intestinal epithelia: getting to the gut of the matter. ( 0,661359585118408 )
AMIA Annu Symp Proc - Adverse Drug Event-based Stratification of Tumor Mutations: A Case Study of Breast Cancer Patients Receiving Aromatase Inhibitors. ( 0,661165153367884 )
J Biomed Inform - Selecting significant genes by randomization test for cancer classification using gene expression data. ( 0,66110014175431 )
Wiley Interdiscip Rev Syst Biol Med - miRNA regulation in the context of functional protein networks: principles and applications. ( 0,654495367737831 )
J Chem Inf Model - Unbinding pathways of GW4064 from human farnesoid X receptor as revealed by molecular dynamics simulations. ( 0,6533089510326 )
Comput Math Methods Med - Molecular signature of cancer at gene level or pathway level? Case studies of colorectal cancer and prostate cancer microarray data. ( 0,651499105784688 )
J Biomed Inform - Hemojuvelin-hepcidin axis modeled and analyzed using Petri nets. ( 0,651102225865595 )
Wiley Interdiscip Rev Syst Biol Med - Regulatory variation: an emerging vantage point for cancer biology. ( 0,646786022419529 )
J Integr Bioinform - Integrating protein-protein interaction networks with gene-gene co-expression networks improves gene signatures for classifying breast cancer metastasis. ( 0,64346654249477 )
Brief. Bioinformatics - Genome-wide identification and predictive modeling of polyadenylation sites in eukaryotes. ( 0,643114069678904 )
Artif Intell Med - Pathway-based identification of a smoking associated 6-gene signature predictive of lung cancer risk and survival. ( 0,638236858825194 )
Wiley Interdiscip Rev Syst Biol Med - Bioimage informatics for understanding spatiotemporal dynamics of cellular processes. ( 0,637795514735254 )
J Integr Bioinform - Computer and statistical analysis of transcription factor binding and chromatin modifications by ChIP-seq data in embryonic stem cell. ( 0,636649328262553 )
J Biomed Inform - Prioritization of potential candidate disease genes by topological similarity of protein-protein interaction network and phenotype data. ( 0,634824896642 )
J Integr Bioinform - Knowledge enrichment analysis for human tissue-specific genes uncover new biological insights. ( 0,631426362360614 )
J Am Med Inform Assoc - Identifying survival associated morphological features of triple negative breast cancer using multiple datasets. ( 0,631360728275509 )
J Biomed Inform - Drug target identification in sphingolipid metabolism by computational systems biology tools: metabolic control analysis and metabolic pathway analysis. ( 0,631243247933906 )
AMIA Annu Symp Proc - Genetic variants improve breast cancer risk prediction on mammograms. ( 0,630714886853753 )
Comput Biol Chem - Computational analysis of 3'UTR region of CASP3 with respect to miRSNPs and SNPs in targetting miRNAs. ( 0,628905642485591 )
Sci Data - The systematic identification of cytoskeletal genes required for Drosophila melanogaster muscle maintenance. ( 0,627809689985704 )
Wiley Interdiscip Rev Syst Biol Med - Genomics and epigenomics of colorectal cancer. ( 0,627104330182992 )
Comput. Biol. Med. - Mathematical modeling and sensitivity analysis of the integrated TNFa-mediated apoptotic pathway for identifying key regulators. ( 0,626836616893173 )
Wiley Interdiscip Rev Syst Biol Med - Genome-wide approaches in the study of microRNA biology. ( 0,625027241537136 )
Wiley Interdiscip Rev Syst Biol Med - Toward a quantitative understanding of the Wnt/?-catenin pathway through simulation and experiment. ( 0,624269478163373 )
J Chem Inf Model - Scoring function based approach for locating binding sites and understanding recognition mechanism of protein-DNA complexes. ( 0,622960691246704 )
J Am Med Inform Assoc - Advantages of genomic complexity: bioinformatics opportunities in microRNA cancer signatures. ( 0,619188916364867 )
Wiley Interdiscip Rev Syst Biol Med - Modeling cellular compartmentation in one-carbon metabolism. ( 0,619167642416075 )
Wiley Interdiscip Rev Syst Biol Med - Noncoding RNAs in gene regulation. ( 0,618099111492572 )
J. Comput. Biol. - Computational disease gene prioritization: an appraisal. ( 0,616767461661685 )
Comput. Biol. Med. - Identification and analysis of the regulatory network of Myc and microRNAs from high-throughput experimental data. ( 0,61342045358846 )
J. Comput. Biol. - Bioinformatics method to analyze the mechanism of pancreatic cancer disorder. ( 0,611460596992774 )
Methods Inf Med - Identification of breast cancer prognosis markers using integrative sparse boosting. ( 0,611410720793544 )
Comput Biol Chem - On the modelling and analysis of the regulatory network of dengue virus pathogenesis and clearance. ( 0,61128448639179 )
Comput Math Methods Med - Genomic biomarkers for personalized medicine: development and validation in clinical studies. ( 0,608803413730044 )
J Chem Inf Model - Molecular dynamics simulations reveal a novel mechanism for ATP inhibition of insulin degrading enzyme. ( 0,608623624398759 )
Wiley Interdiscip Rev Syst Biol Med - The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation. ( 0,606954630737994 )
Brief. Bioinformatics - Evolution of gene regulation--on the road towards computational inferences. ( 0,604926215382916 )
J Biomed Inform - Where we stand, where we are moving: Surveying computational techniques for identifying miRNA genes and uncovering their regulatory role. ( 0,604493057496331 )
Comput. Biol. Med. - A review on the computational approaches for gene regulatory network construction. ( 0,604355219222787 )
Wiley Interdiscip Rev Syst Biol Med - Recent advances in prostate development and links to prostatic diseases. ( 0,603614712372772 )
Wiley Interdiscip Rev Syst Biol Med - Using variability in gene expression as a tool for studying gene regulation. ( 0,601641452655843 )
Wiley Interdiscip Rev Syst Biol Med - Protein microarrays for genome-wide posttranslational modification analysis. ( 0,601152802597661 )
Wiley Interdiscip Rev Syst Biol Med - Branched-chain amino acid supplementation: impact on signaling and relevance to critical illness. ( 0,600396243162384 )
Comput Math Methods Med - Dynamic regulatory network reconstruction for Alzheimer's disease based on matrix decomposition techniques. ( 0,600396056538716 )
J Chem Inf Model - 3D-QSAR based on quantum-chemical molecular fields: toward an improved description of halogen interactions. ( 0,60026252287423 )
Comput. Biol. Med. - Screening for cancer associated MiRNAs through co-gene, co-function and co-pathway analysis. ( 0,59968824314928 )
Med Biol Eng Comput - Cell sheet integrity and nanomechanical breakdown during programmed cell death. ( 0,598673493087042 )
Wiley Interdiscip Rev Syst Biol Med - Diverse functional networks of Tbx3 in development and disease. ( 0,596767158957533 )
Comput Math Methods Med - Understanding the pathogenesis of Kawasaki disease by network and pathway analysis. ( 0,596326953068764 )
Brief. Bioinformatics - A statistical procedure to map high-order epistasis for complex traits. ( 0,596068081365492 )
Comput. Aided Surg. - A method for three-dimensional evaluation and computer aided treatment of femoroacetabular impingement. ( 0,59574954540428 )
J Chem Inf Model - Ligand binding and functional selectivity of L-tryptophan metabolites at the mouse aryl hydrocarbon receptor (mAhR). ( 0,59512408882628 )
Comput Biol Chem - Mutually exclusive binding of APPL(PH) to BAR domain and Reptin regulates ?-catenin dependent transcriptional events. ( 0,594942361604643 )
Brief. Bioinformatics - Literature-aided interpretation of gene expression data with the weighted global test. ( 0,594827807233917 )
Brief. Bioinformatics - Identifying miRNAs, targets and functions. ( 0,594744424297158 )
Brief. Bioinformatics - Bayesian inference for genomic imprinting underlying developmental characteristics. ( 0,593088132775067 )
J Am Med Inform Assoc - Network models of genome-wide association studies uncover the topological centrality of protein interactions in complex diseases. ( 0,593074889914479 )
Comput Biol Chem - Using gene expression programming to infer gene regulatory networks from time-series data. ( 0,592916170397508 )
Sci Data - Genome-wide functional genomic and transcriptomic analyses for genes regulating sensitivity to vorinostat. ( 0,592602241807908 )
Comput. Biol. Med. - A molecular prospective provides new insights into implication of PDYN and OPRK1 genes in alcohol dependence. ( 0,592507935298115 )
Comput Math Methods Med - First comprehensive in silico analysis of the functional and structural consequences of SNPs in human GalNAc-T1 gene. ( 0,59138297151416 )
Brief. Bioinformatics - Exploring the function of genetic variants in the non-coding genomic regions: approaches for identifying human regulatory variants affecting gene expression. ( 0,590852419530225 )
J Biomed Inform - Data driven linear algebraic methods for analysis of molecular pathways: application to disease progression in shock/trauma. ( 0,590199020433726 )
Wiley Interdiscip Rev Syst Biol Med - Mediators and dynamics of DNA methylation. ( 0,590178500600711 )
Wiley Interdiscip Rev Syst Biol Med - Systems vaccinology: learning to compute the behavior of vaccine induced immunity. ( 0,5898265720203 )
Brief. Bioinformatics - A model-free approach for detecting interactions in genetic association studies. ( 0,588874673981742 )
J. Comput. Biol. - A topology-based score for pathway enrichment. ( 0,587909129796871 )
AMIA Annu Symp Proc - Towards mechanism classifiers: expression-anchored Gene Ontology signature predicts clinical outcome in lung adenocarcinoma patients. ( 0,587691693070795 )
Sci Data - Transcriptomic analysis of midbrain and individual hindbrain rhombomeres in the chick embryo. ( 0,586974535285218 )
Brief. Bioinformatics - A quantitative model of transcriptional differentiation driving host-pathogen interactions. ( 0,585478656927764 )
J. Comput. Biol. - Biological network querying techniques: analysis and comparison. ( 0,585273423315624 )
Comput Biol Chem - Expression patterns of photoperiod and temperature regulated heading date genes in Oryza sativa. ( 0,584705017437699 )
AMIA Annu Symp Proc - Comparing the value of mammographic features and genetic variants in breast cancer risk prediction. ( 0,584212308061534 )
Brief. Bioinformatics - Apoptosis regulatory protein-protein interaction demonstrates hierarchical scale-free fractal network. ( 0,584208965827229 )
J Am Med Inform Assoc - Identifying disease genes and module biomarkers by differential interactions. ( 0,583506675022699 )
Comput Biol Chem - Disruption of murine Tcte3-3 induces tissue specific apoptosis via co-expression of Anxa5 and Pebp1. ( 0,583092857117766 )
Wiley Interdiscip Rev Syst Biol Med - Understanding multimodal biological decisions from single cell and population dynamics. ( 0,582226760313165 )
J Am Med Inform Assoc - 'N-of-1-pathways' unveils personal deregulated mechanisms from a single pair of RNA-Seq samples: towards precision medicine. ( 0,581208060919254 )
J. Comput. Biol. - Informational requirements for transcriptional regulation. ( 0,580564732669741 )
J Biomed Inform - Systems-based biological concordance and predictive reproducibility of gene set discovery methods in cardiovascular disease. ( 0,580164019979404 )
Comput Biol Chem - GPEC: a Cytoscape plug-in for random walk-based gene prioritization and biomedical evidence collection. ( 0,579692314809679 )
Comput Biol Chem - Identification of novel splice variants and exons of human endothelial cell-specific chemotaxic regulator (ECSCR) by bioinformatics analysis. ( 0,579650825481362 )
J Chem Inf Model - Molecular dynamics studies of the STAT3 homodimer:DNA complex: relationships between STAT3 mutations and protein-DNA recognition. ( 0,579162629060229 )