Comput Math Methods Med - A novel weighted support vector machine based on particle swarm optimization for gene selection and tumor classification.

Tópicos

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Resumo

We develop a detection model based on support vector machines (SVMs) and particle swarm optimization (PSO) for gene selection and tumor classification problems. The proposed model consists of two stages: first, the well-known minimum redundancy-maximum relevance (mRMR) method is applied to preselect genes that have the highest relevance with the target class and are maximally dissimilar to each other. Then, PSO is proposed to form a novel weighted SVM (WSVM) to classify samples. In this WSVM, PSO not only discards redundant genes, but also especially takes into account the degree of importance of each gene and assigns diverse weights to the different genes. We also use PSO to find appropriate kernel parameters since the choice of gene weights influences the optimal kernel parameters and vice versa. Experimental results show that the proposed mRMR-PSO-WSVM model achieves highest classification accuracy on two popular leukemia and colon gene expression datasets obtained from DNA microarrays. Therefore, we can conclude that our proposed method is very promising compared to the previously reported results.

Resumo Limpo

develop detect model base support vector machin svms particl swarm optim pso gene select tumor classif problem propos model consist two stage first wellknown minimum redundancymaximum relev mrmr method appli preselect gene highest relev target class maxim dissimilar pso propos form novel weight svm wsvm classifi sampl wsvm pso discard redund gene also especi take account degre import gene assign divers weight differ gene also use pso find appropri kernel paramet sinc choic gene weight influenc optim kernel paramet vice versa experiment result show propos mrmrpsowsvm model achiev highest classif accuraci two popular leukemia colon gene express dataset obtain dna microarray therefor can conclud propos method promis compar previous report result

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