Comput Math Methods Med - Relationship between concentration difference of different density lipoproteins and shear stress in atherosclerosis.

Tópicos

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Resumo

Previous research has observed concentration polarization in LDL and HDL in the arterial system. However, there is no report that links this concentration polarization to the development of vascular atherosclerosis (AS). Therefore, the purpose of this study is to establish the relationship between concentration difference of LDL and HDL and shear stress using a carotid bifurcation vascular model. PTFE was employed to create the carotid bifurcation model. Endothelial cells were coated on the inner wall of the graft. In a recirculation system, HDL and LDL concentration were measured under two different ICA flow velocities at 5 different locations within our model. We report the following: (1) LDL and HDL concentration difference was observed in both high flow and low flow environments; (2) the degree of LDL and HDL concentration polarization varied depending of high flow and low flow environment; (3) absolute values of concentration difference between LDL and HDL at the inner wall surface decreased with the increase in shear stress when shear stress was more than 1.5Pa. This variation trend would be more pronounced if shear stress were less than 0.5Pa. Our study suggests that under the action of shear stress, concentration differences of LDL or HDL create a disturbance in the balance of atherogenic factors and anti-As factors, resulting in the occurrence of AS.

Resumo Limpo

previous research observ concentr polar ldl hdl arteri system howev report link concentr polar develop vascular atherosclerosi therefor purpos studi establish relationship concentr differ ldl hdl shear stress use carotid bifurc vascular model ptfe employ creat carotid bifurc model endotheli cell coat inner wall graft recircul system hdl ldl concentr measur two differ ica flow veloc differ locat within model report follow ldl hdl concentr differ observ high flow low flow environ degre ldl hdl concentr polar vari depend high flow low flow environ absolut valu concentr differ ldl hdl inner wall surfac decreas increas shear stress shear stress pa variat trend pronounc shear stress less pa studi suggest action shear stress concentr differ ldl hdl creat disturb balanc atherogen factor antia factor result occurr

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