Comput Math Methods Med - Therapeutic vascular compliance change may cause significant variation in coronary perfusion: a numerical study.

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Resumo

In some pathological conditions like aortic stiffening and calcific aortic stenosis (CAS), the microstructure of the aortic root and the aortic valve leaflets are altered in response to stress resulting in changes in tissue thickness, stiffness, or both. This aortic stiffening and CAS are thought to affect coronary blood flow. The goal of the present paper was to include the flow in the coronary ostia in the previous fluid structure interaction model we have developed and to analyze the effect of diseased tissues (aortic root stiffening and CAS) on coronary perfusion. Results revealed a significant impact on the coronary perfusion due to a moderate increase in the aortic wall stiffness and CAS (increase of the aortic valve leaflets thickness). A marked drop of coronary peak velocity occurred when the values of leaflet thickness and aortic wall stiffness were above a certain threshold, corresponding to a threefold of their normal value. Consequently, mild and prophylactic treatments such as smoking cessation, exercise, or diet, which have been proven to increase the aortic compliance, may significantly improve the coronary perfusion.

Resumo Limpo

patholog condit like aortic stiffen calcif aortic stenosi cas microstructur aortic root aortic valv leaflet alter respons stress result chang tissu thick stiff aortic stiffen cas thought affect coronari blood flow goal present paper includ flow coronari ostia previous fluid structur interact model develop analyz effect diseas tissu aortic root stiffen cas coronari perfus result reveal signific impact coronari perfus due moder increas aortic wall stiff cas increas aortic valv leaflet thick mark drop coronari peak veloc occur valu leaflet thick aortic wall stiff certain threshold correspond threefold normal valu consequ mild prophylact treatment smoke cessat exercis diet proven increas aortic complianc may signific improv coronari perfus

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