Comput Math Methods Med - An estrogen model: the relationship between body mass index, menopausal status, estrogen replacement therapy, and breast cancer risk.

Tópicos

{ cancer(2502) breast(956) screen(824) }
{ time(1939) patient(1703) rate(768) }
{ model(2656) set(1616) predict(1553) }
{ risk(3053) factor(974) diseas(938) }
{ general(901) number(790) one(736) }
{ use(1733) differ(960) four(931) }
{ patient(2315) diseas(1263) diabet(1191) }
{ model(2341) predict(2261) use(1141) }
{ spatial(1525) area(1432) region(1030) }
{ state(1844) use(1261) util(961) }
{ activ(1138) subject(705) human(624) }
{ treatment(1704) effect(941) patient(846) }
{ method(1557) propos(1049) approach(1037) }
{ method(984) reconstruct(947) comput(926) }
{ case(1353) use(1143) diagnosi(1136) }
{ studi(1410) differ(1259) use(1210) }
{ medic(1828) order(1363) alert(1069) }
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{ use(976) code(926) identifi(902) }
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{ model(3480) simul(1196) paramet(876) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
{ gene(2352) biolog(1181) express(1162) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ analysi(2126) use(1163) compon(1037) }
{ health(1844) social(1437) communiti(874) }
{ structur(1116) can(940) graph(676) }
{ high(1669) rate(1365) level(1280) }
{ drug(1928) target(777) effect(648) }
{ result(1111) use(1088) new(759) }
{ implement(1333) system(1263) develop(1122) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ process(1125) use(805) approach(778) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1969) cluster(1462) data(1082) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

We present a mathematical model that lends support to the hypothesis that estrogen levels mediate the complex relationship between body mass index (BMI), menopausal status, estrogen-only hormone replacement therapy (HRT), and breast cancer risk. The model predicts a decrease in the relative risk of breast cancer of 3% per unit increase in BMI (kg/m(2)) for premenopausal women and an increase in the relative risk of 4% per unit increase in BMI for postmenopausal women who are not HRT users. When comparing postmenopausal women who use estrogen-only HRT to postmenopausal women who do not use HRT, the model predicts an increased risk of breast cancer associated with use of estrogen that diminishes with increasing BMI, with a relative risk of 1.6 for women with BMI of 18, 1.2 for women with BMI of 25, and 1.0 for women with BMI = 30. Model predictions agree with data from five major epidemiological studies.

Resumo Limpo

present mathemat model lend support hypothesi estrogen level mediat complex relationship bodi mass index bmi menopaus status estrogenon hormon replac therapi hrt breast cancer risk model predict decreas relat risk breast cancer per unit increas bmi kgm premenopaus women increas relat risk per unit increas bmi postmenopaus women hrt user compar postmenopaus women use estrogenon hrt postmenopaus women use hrt model predict increas risk breast cancer associ use estrogen diminish increas bmi relat risk women bmi women bmi women bmi model predict agre data five major epidemiolog studi

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