Comput Methods Programs Biomed - Growth plate stress distribution implications during bone development: a simple framework computational approach.

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Resumo

Mechanical stimuli play a significant role in the process of long bone development as evidenced by clinical observations and in vivo studies. Up to now approaches to understand stimuli characteristics have been limited to the first stages of epiphyseal development. Furthermore, growth plate mechanical behavior has not been widely studied. In order to better understand mechanical influences on bone growth, we used Carter and Wong biomechanical approximation to analyze growth plate mechanical behavior, and explore stress patterns for different morphological stages of the growth plate. To the best of our knowledge this work is the first attempt to study stress distribution on growth plate during different possible stages of bone development, from gestation to adolescence. Stress distribution analysis on the epiphysis and growth plate was performed using axisymmetric (3D) finite element analysis in a simplified generic epiphyseal geometry using a linear elastic model as the first approximation. We took into account different growth plate locations, morphologies and widths, as well as different epiphyseal developmental stages. We found stress distribution during bone development established osteogenic index patterns that seem to influence locally epiphyseal structures growth and coincide with growth plate histological arrangement.

Resumo Limpo

mechan stimuli play signific role process long bone develop evidenc clinic observ vivo studi now approach understand stimuli characterist limit first stage epiphys develop furthermor growth plate mechan behavior wide studi order better understand mechan influenc bone growth use carter wong biomechan approxim analyz growth plate mechan behavior explor stress pattern differ morpholog stage growth plate best knowledg work first attempt studi stress distribut growth plate differ possibl stage bone develop gestat adolesc stress distribut analysi epiphysi growth plate perform use axisymmetr d finit element analysi simplifi generic epiphys geometri use linear elast model first approxim took account differ growth plate locat morpholog width well differ epiphys development stage found stress distribut bone develop establish osteogen index pattern seem influenc local epiphys structur growth coincid growth plate histolog arrang

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