Comput Methods Programs Biomed - HELOW: a program for testing extreme homogeneity in meta-analysis.

Tópicos

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Resumo

Meta-analysis aims to synthesize results from different studies. Although, in a meta-analysis the presence of large between-study heterogeneity is routinely evaluated, in some instances is also important to probe whether there is extreme between-study homogeneity (i.e. extreme low between-study heterogeneity). HELOW (HEterogeneity LOW) is a program for testing extreme homogeneity in a meta-analysis of risk ratios when binary outcome and Mantel-Haenszel fixed effects summary risk ratio estimate are employed. The significance of extreme homogeneity is assessed using a Monte Carlo test. Extreme homogeneity may yield insights for the statistical and clinical interpretation of the data.

Resumo Limpo

metaanalysi aim synthes result differ studi although metaanalysi presenc larg betweenstudi heterogen routin evalu instanc also import probe whether extrem betweenstudi homogen ie extrem low betweenstudi heterogen helow heterogen low program test extrem homogen metaanalysi risk ratio binari outcom mantelhaenszel fix effect summari risk ratio estim employ signific extrem homogen assess use mont carlo test extrem homogen may yield insight statist clinic interpret data

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