Comput Methods Programs Biomed - Cerebral arterial inflow assessment with 18F-FDG PET: methodology and feasibility.

Tópicos

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Resumo

Positron emission tomography (PET) with 18fluorodeoxyglucose (18F-FDG) is increasingly used in neurology. The measurement of cerebral arterial inflow (QA) using 18F-FDG complements the information provided by standard brain PET imaging. Here, injections were performed after the beginning of dynamic acquisitions and the time to arrival (t0) of activity in the gantry's field of view was computed. We performed a phantom study using a branched tube (internal diameter: 4mm) and a 18F-FDG solution injected at 240 mL/min. Data processing consisted of (i) reconstruction of the first 3s after t0, (ii) vascular signal enhancement and (iii) clustering. This method was then applied in four subjects. We measured the volumes of the tubes or vascular trees and calculated the corresponding flows. In the phantom, the flow was calculated to be 244.2 mL/min. In each subject, our QA value was compared with that obtained by quantitative cine-phase contrast magnetic resonance imaging; the mean QA value of 581.4?217.5 mL/min calculated with 18F-FDG PET was consistent with the mean value of 593.3?205.8 mL/min calculated with quantitative cine-phase contrast magnetic resonance imaging. Our 18F-FDG PET method constitutes a novel, fully automatic means of measuring QA.

Resumo Limpo

positron emiss tomographi pet fluorodeoxyglucos ffdg increas use neurolog measur cerebr arteri inflow qa use ffdg complement inform provid standard brain pet imag inject perform begin dynam acquisit time arriv t activ gantri field view comput perform phantom studi use branch tube intern diamet mm ffdg solut inject mlmin data process consist reconstruct first s t ii vascular signal enhanc iii cluster method appli four subject measur volum tube vascular tree calcul correspond flow phantom flow calcul mlmin subject qa valu compar obtain quantit cinephas contrast magnet reson imag mean qa valu mlmin calcul ffdg pet consist mean valu mlmin calcul quantit cinephas contrast magnet reson imag ffdg pet method constitut novel fulli automat mean measur qa

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