Comput Methods Programs Biomed - A new algorithm for quadratic sample entropy optimization for very short biomedical signals: application to blood pressure records.


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This paper describes a new method to optimize the computation of the quadratic sample entropy (QSE) metric. The objective is to enhance its segmentation capability between pathological and healthy subjects for short and unevenly sampled biomedical records, like those obtained using ambulatory blood pressure monitoring (ABPM). In ABPM, blood pressure is measured every 20-30 min during 24h while patients undergo normal daily activities. ABPM is indicated for a number of applications such as white-coat, suspected, borderline, or masked hypertension. Hypertension is a very important clinical issue that can lead to serious health implications, and therefore its identification and characterization is of paramount importance. Nonlinear processing of signals by means of entropy calculation algorithms has been used in many medical applications to distinguish among signal classes. However, most of these methods do not perform well if the records are not long enough and/or not uniformly sampled. That is the case for ABPM records. These signals are extremely short and scattered with outliers or missing/resampled data. This is why ABPM Blood pressure signal screening using nonlinear methods is a quite unexplored field. We propose an additional stage for the computation of QSE independently of its parameter r and the input signal length. This enabled us to apply a segmentation process to ABPM records successfully. The experimental dataset consisted of 61 blood pressure data records of control and pathological subjects with only 52 samples per time series. The entropy estimation values obtained led to the segmentation of the two groups, while other standard nonlinear methods failed.

Resumo Limpo

paper describ new method optim comput quadrat sampl entropi qse metric object enhanc segment capabl patholog healthi subject short uneven sampl biomed record like obtain use ambulatori blood pressur monitor abpm abpm blood pressur measur everi min h patient undergo normal daili activ abpm indic number applic whitecoat suspect borderlin mask hypertens hypertens import clinic issu can lead serious health implic therefor identif character paramount import nonlinear process signal mean entropi calcul algorithm use mani medic applic distinguish among signal class howev method perform well record long enough andor uniform sampl case abpm record signal extrem short scatter outlier missingresampl data abpm blood pressur signal screen use nonlinear method quit unexplor field propos addit stage comput qse independ paramet r input signal length enabl us appli segment process abpm record success experiment dataset consist blood pressur data record control patholog subject sampl per time seri entropi estim valu obtain led segment two group standard nonlinear method fail

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