Comput Methods Programs Biomed - A SAS macro for direct adjusted survival curves based on Aalen's additive model.

Tópicos

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{ framework(1458) process(801) describ(734) }
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Resumo

Aalen's additive model defines the covariate effects on the survival outcome to be time-varying. The aim of this paper is to explore the application of Aalen's model in assessing treatment effects, adjusting for possibly different patient profiles between the treatment groups. We treat Aalen's model as the underlying model and compute the direct adjusted survival curves for different treatments. The treatment comparison can be performed by finding a confidence interval for the difference between two direct adjusted survivals. We developed a SAS macro that calculates the direct adjusted survival estimates and the standard errors, based on Aalen's model. In this paper, we give two examples to explain the syntax for using the macro.

Resumo Limpo

aalen addit model defin covari effect surviv outcom timevari aim paper explor applic aalen model assess treatment effect adjust possibl differ patient profil treatment group treat aalen model under model comput direct adjust surviv curv differ treatment treatment comparison can perform find confid interv differ two direct adjust surviv develop sas macro calcul direct adjust surviv estim standard error base aalen model paper give two exampl explain syntax use macro

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