Comput Methods Programs Biomed - Assessment of ventricular contractility and ventricular-arterial coupling with a model-based sensor.


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Estimation of ventricular contractility and ventricular arterial coupling is clinically important in diagnosing and treating cardiac dysfunction in the critically ill. However, experimental assessment of indexes of ventricular contractility, such as the end-systolic pressure-volume relationship, requires a highly invasive maneuver and measurements that are not typical in an intensive care unit (ICU). This research describes the use of a previously validated cardiovascular system model and parameter identification process to evaluate the right ventricular arterial coupling in septic shock. Model-based ventricular arterial coupling is defined by the ratio of the end systolic right ventricular elastance (E(esrvf)) over the pulmonary artery elastance (E(pa)) or the mean pulmonary inflow resistance (R(pulin)). Results are compared to the clinical gold-standard assessment (conductance catheter method). Six anesthetized healthy pigs weighing 20-30kg received a 0.5mg kg(-1) endotoxin infusion over a period of 30min from T0 to T30, to induce septic shock and veno-venous hemofiltration was used from T60 onward. The results show good agreement with the gold-standard experimental assessment. In particular, the model-based right ventricular elastance (E(esrvf)) correlates well with the clinical gold standard (R(2)=0.69) and the model-based non-invasive coupling (E(esrvf)/R(pulin)) follow the same trends and dynamics (R(2)=0.37). The overall results show the potential to develop a model-based sensor to monitor ventricular-arterial coupling in clinical real-time.

Resumo Limpo

estim ventricular contractil ventricular arteri coupl clinic import diagnos treat cardiac dysfunct critic ill howev experiment assess index ventricular contractil endsystol pressurevolum relationship requir high invas maneuv measur typic intens care unit icu research describ use previous valid cardiovascular system model paramet identif process evalu right ventricular arteri coupl septic shock modelbas ventricular arteri coupl defin ratio end systol right ventricular elast eesrvf pulmonari arteri elast epa mean pulmonari inflow resist rpulin result compar clinic goldstandard assess conduct cathet method six anesthet healthi pig weigh kg receiv mg kg endotoxin infus period min t t induc septic shock venoven hemofiltr use t onward result show good agreement goldstandard experiment assess particular modelbas right ventricular elast eesrvf correl well clinic gold standard r modelbas noninvas coupl eesrvfrpulin follow trend dynam r overal result show potenti develop modelbas sensor monitor ventriculararteri coupl clinic realtim

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