Comput Methods Programs Biomed - Minimising retinal vessel artefacts in optical coherence tomography images.

Tópicos

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Resumo

Optical coherence tomography (OCT) is commonly used to investigate the layers of the retina including retinal nerve fiber layer (RNFL) and retinal pigment epithelium (RPE). OCT images are altered by vessels on the retinal surface producing artefacts. We propose a new approach to compensate for these artefacts and enhance quality of OCT images. A total of 28 (20 normal and 8 glaucoma subjects) OCT images were obtained using Spectralis (Heidelberg, Germany). Shadows were detected along the image and compensated by the A-Scan intensity difference from surrounding non-affected areas. Images were then segmented and the area and thickness of RNFL and RPE were measured and compared. 10 subjects were tested twice to determine the effect of this on reproducibility of measurements. Shadow-suppressed images reflected the profile of the retinal layers more closely when assessed qualitatively, minimising distortion. The segmentation of RNFL and RPE thickness demonstrated a mean change of 2.4% ? 1 and 6% ? 1 from the original images. Much larger changes were observed in areas with vessels. Reproducibility of RNFL thickness was improved, specifically in the higher density vessel location, i.e. inferior and superior. Therefore, OCT images can be enhanced by an image processing procedure. Vessel artefacts may cause errors in assessment of RNFL thickness and are a source of variability, which has clinical implications for diseases such as glaucoma where subtle changes in RNFL need to be monitored accurately over time.

Resumo Limpo

optic coher tomographi oct common use investig layer retina includ retin nerv fiber layer rnfl retin pigment epithelium rpe oct imag alter vessel retin surfac produc artefact propos new approach compens artefact enhanc qualiti oct imag total normal glaucoma subject oct imag obtain use spectrali heidelberg germani shadow detect along imag compens ascan intens differ surround nonaffect area imag segment area thick rnfl rpe measur compar subject test twice determin effect reproduc measur shadowsuppress imag reflect profil retin layer close assess qualit minimis distort segment rnfl rpe thick demonstr mean chang origin imag much larger chang observ area vessel reproduc rnfl thick improv specif higher densiti vessel locat ie inferior superior therefor oct imag can enhanc imag process procedur vessel artefact may caus error assess rnfl thick sourc variabl clinic implic diseas glaucoma subtl chang rnfl need monitor accur time

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