Comput Methods Programs Biomed - Validated finite element models of the proximal femur using two-dimensional projected geometry and bone density.


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Two-dimensional finite element models of cadaveric femoral stiffness were developed to study their suitability as surrogates of bone stiffness and strength, using two-dimensional representations of femoral geometry and bone mineral density distributions. If successfully validated, such methods could be clinically applied to estimate patient bone stiffness and strength using simpler and less costly radiographs. Two-dimensional femur images were derived by projection of quantitative computed tomography scans of 22 human cadaveric femurs. The same femurs were fractured in a fall on the hip configuration. Femoral stiffness and fracture load were measured, and high speed video was recorded. Digital image correlation analysis was used to calculate the strain distribution from the high speed video recordings. Two-dimensional projection images were segmented and meshed with second-order triangular elements for finite element analysis. Elastic moduli of the finite elements were calculated based on the projected mineral density values inside the elements. The mapping of projection density values to elastic modulus was obtained using optimal parameter identification in a set of nine of the 22 specimens, and validated on the remaining 13 specimens. Finite element calculated proximal stiffness and strength correlated much better with experimental data than areal bone mineral density alone. In addition, finite element calculated strain distributions compared very well with strains obtained from digital image processing of the high speed video recordings, further validating the two-dimensional projected subject-specific finite element models.

Resumo Limpo

twodimension finit element model cadaver femor stiff develop studi suitabl surrog bone stiff strength use twodimension represent femor geometri bone miner densiti distribut success valid method clinic appli estim patient bone stiff strength use simpler less cost radiograph twodimension femur imag deriv project quantit comput tomographi scan human cadaver femur femur fractur fall hip configur femor stiff fractur load measur high speed video record digit imag correl analysi use calcul strain distribut high speed video record twodimension project imag segment mesh secondord triangular element finit element analysi elast moduli finit element calcul base project miner densiti valu insid element map project densiti valu elast modulus obtain use optim paramet identif set nine specimen valid remain specimen finit element calcul proxim stiff strength correl much better experiment data areal bone miner densiti alon addit finit element calcul strain distribut compar well strain obtain digit imag process high speed video record valid twodimension project subjectspecif finit element model

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