Comput Methods Programs Biomed - Online analysis of in vitro resistance to antimalarial drugs through nonlinear regression.

Tópicos

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Resumo

Malaria remains one of the leading causes of morbidity and mortality worldwide which is partly due to the emergence of the parasite resistance to antimalarial drugs. In vitro testing of drugs allows an early detection of resistance. The common parameter used for the monitoring of resistance is the concentration that inhibits 50% of the parasite's activity (IC(50)). Various methods of calculation are already used but none of them consider new available tools nor display the precision of IC(50) estimation. We proposed an approach based on the inhibitory sigmoid E(max) model, which is often used in pharmacology, with estimation of IC(50) through nonlinear regression using a standard function of the R software. To facilitate the usage of that tool we have developed an online version available on the website ICEstimator (ICEstimator website http://www.antimalarial-icestimator.net/, 2009) [1]. This website is used by various teams in the world and the user can do the analysis without knowing R using the GUI. This article describes version 2.1 of this website and shows illustration on five different real examples.

Resumo Limpo

malaria remain one lead caus morbid mortal worldwid part due emerg parasit resist antimalari drug vitro test drug allow earli detect resist common paramet use monitor resist concentr inhibit parasit activ ic various method calcul alreadi use none consid new avail tool display precis ic estim propos approach base inhibitori sigmoid emax model often use pharmacolog estim ic nonlinear regress use standard function r softwar facilit usag tool develop onlin version avail websit icestim icestim websit httpwwwantimalarialicestimatornet websit use various team world user can analysi without know r use gui articl describ version websit show illustr five differ real exampl

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