Comput Methods Programs Biomed - A patient specific electro-mechanical model of the heart.

Tópicos

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Resumo

This paper presents a patient specific deformable heart model that involves the known electrical and mechanical properties of the cardiac cells and tissue. The whole heart model comprises ten Tusscher's ventricular and Nygren's atrial cell models, the anatomical and electrophysiological model descriptions of the atria (introduced by Harrild et al.) and ventricle (given by Winslow et al.), and the mechanical model of the periodical cardiac contraction and resting phenomena proposed by Moireau et al. During the propagation of the depolarization wave, the kinetic, compositional and rotational anisotropy is handled by the tissue, organ and torso model. The applied patient specific parameters were determined by an evolutionary computation method. An intensive parameter reduction was performed using the abstract formulation of the searching space. This patient specific parameter representation enables the adjustment of deformable model parameters in real-time. The validation process was performed using simultaneously measured ECG and ultrasound image records that were compared with simulated signals and shapes using an abstract, parameterized evaluation criterion.

Resumo Limpo

paper present patient specif deform heart model involv known electr mechan properti cardiac cell tissu whole heart model compris ten tusscher ventricular nygren atrial cell model anatom electrophysiolog model descript atria introduc harrild et al ventricl given winslow et al mechan model period cardiac contract rest phenomena propos moireau et al propag depolar wave kinet composit rotat anisotropi handl tissu organ torso model appli patient specif paramet determin evolutionari comput method intens paramet reduct perform use abstract formul search space patient specif paramet represent enabl adjust deform model paramet realtim valid process perform use simultan measur ecg ultrasound imag record compar simul signal shape use abstract parameter evalu criterion

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