Comput Methods Programs Biomed - Optimal bone density distributions: numerical analysis of the osteocyte spatial influence in bone remodeling.

Tópicos

{ model(2220) cell(1177) simul(1124) }
{ error(1145) method(1030) estim(1020) }
{ general(901) number(790) one(736) }
{ perform(1367) use(1326) method(1137) }
{ estim(2440) model(1874) function(577) }
{ measur(2081) correl(1212) valu(896) }
{ compound(1573) activ(1297) structur(1058) }
{ network(2748) neural(1063) input(814) }
{ problem(2511) optim(1539) algorithm(950) }
{ group(2977) signific(1463) compar(1072) }
{ first(2504) two(1366) second(1323) }
{ cancer(2502) breast(956) screen(824) }
{ model(3404) distribut(989) bayesian(671) }
{ system(1976) rule(880) can(841) }
{ imag(2830) propos(1344) filter(1198) }
{ model(3480) simul(1196) paramet(876) }
{ cost(1906) reduc(1198) effect(832) }
{ structur(1116) can(940) graph(676) }
{ drug(1928) target(777) effect(648) }
{ imag(1947) propos(1133) code(1026) }
{ sequenc(1873) structur(1644) protein(1328) }
{ chang(1828) time(1643) increas(1301) }
{ design(1359) user(1324) use(1319) }
{ risk(3053) factor(974) diseas(938) }
{ import(1318) role(1303) understand(862) }
{ model(2341) predict(2261) use(1141) }
{ visual(1396) interact(850) tool(830) }
{ studi(1119) effect(1106) posit(819) }
{ spatial(1525) area(1432) region(1030) }
{ ehr(2073) health(1662) electron(1139) }
{ sampl(1606) size(1419) use(1276) }
{ gene(2352) biolog(1181) express(1162) }
{ activ(1138) subject(705) human(624) }
{ can(981) present(881) function(850) }
{ high(1669) rate(1365) level(1280) }
{ use(976) code(926) identifi(902) }
{ result(1111) use(1088) new(759) }
{ process(1125) use(805) approach(778) }
{ method(2212) result(1239) propos(1039) }
{ can(774) often(719) complex(702) }
{ data(1737) use(1416) pattern(1282) }
{ inform(2794) health(2639) internet(1427) }
{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
{ method(1219) similar(1157) match(930) }
{ featur(3375) classif(2383) classifi(1994) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ take(945) account(800) differ(722) }
{ studi(2440) review(1878) systemat(933) }
{ motion(1329) object(1292) video(1091) }
{ assess(1506) score(1403) qualiti(1306) }
{ treatment(1704) effect(941) patient(846) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ framework(1458) process(801) describ(734) }
{ learn(2355) train(1041) set(1003) }
{ concept(1167) ontolog(924) domain(897) }
{ clinic(1479) use(1117) guidelin(835) }
{ algorithm(1844) comput(1787) effici(935) }
{ extract(1171) text(1153) clinic(932) }
{ method(1557) propos(1049) approach(1037) }
{ data(1714) softwar(1251) tool(1186) }
{ control(1307) perform(991) simul(935) }
{ care(1570) inform(1187) nurs(1089) }
{ method(984) reconstruct(947) comput(926) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ case(1353) use(1143) diagnosi(1136) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ studi(1410) differ(1259) use(1210) }
{ perform(999) metric(946) measur(919) }
{ research(1085) discuss(1038) issu(1018) }
{ system(1050) medic(1026) inform(1018) }
{ blood(1257) pressur(1144) flow(957) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ monitor(1329) mobil(1314) devic(1160) }
{ state(1844) use(1261) util(961) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ data(3008) multipl(1320) sourc(1022) }
{ intervent(3218) particip(2042) group(1664) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ analysi(2126) use(1163) compon(1037) }
{ health(1844) social(1437) communiti(874) }
{ use(1733) differ(960) four(931) }
{ implement(1333) system(1263) develop(1122) }
{ survey(1388) particip(1329) question(1065) }
{ decis(3086) make(1611) patient(1517) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1969) cluster(1462) data(1082) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

In this paper a control and optimization procedure for bone remodeling simulations was adopted to study the effect of the osteocyte influence range on the predicted density distribution. In order to reach this goal, the osteocyte network regulating bone remodeling process in a 2-D bone sample was numerically simulated. The assumed proportional-integral-derivative (PID) bone remodeling rule was related to the error signal between the strain energy density and a selected target. Furthermore the control parameters and the target were optimally determined minimizing a suitable cost index: the goal was to minimize the final mass and the energy thus maximizing the stiffness. The continuum model results show that the developed and adapted trabecular structure was consistent with the applied loads and only depended on the external forces, the value of the cost index, the maximum attainable elastic modulus value (hence, the maximum density value) and the value of the energy target. The remodeling phenomenon determined the number and thickness of the trabeculae which are formed from a uniform distribution of mass density in the considered domain; this number and these thicknesses are controlled by the values assigned to the parameters of the model. In particular, the osteocyte decay distance (D) of the influence range affected the trabecular patterns formation, showing an important effect in the adaptive capacity of the optimization numerical model.

Resumo Limpo

paper control optim procedur bone remodel simul adopt studi effect osteocyt influenc rang predict densiti distribut order reach goal osteocyt network regul bone remodel process d bone sampl numer simul assum proportionalintegralderiv pid bone remodel rule relat error signal strain energi densiti select target furthermor control paramet target optim determin minim suitabl cost index goal minim final mass energi thus maxim stiff continuum model result show develop adapt trabecular structur consist appli load depend extern forc valu cost index maximum attain elast modulus valu henc maximum densiti valu valu energi target remodel phenomenon determin number thick trabecula form uniform distribut mass densiti consid domain number thick control valu assign paramet model particular osteocyt decay distanc d influenc rang affect trabecular pattern format show import effect adapt capac optim numer model

Resumos Similares

Med Biol Eng Comput - Multi-scale study of nanoparticle transport and deposition in tissues during an injection process. ( 0,811353106825748 )
Med Biol Eng Comput - Characterization of cellular elastic modulus using structure based double layer model. ( 0,808320238777067 )
Comput Math Methods Med - Morphological measurement of living cells in methanol with digital holographic microscopy. ( 0,800455392960267 )
Comput. Biol. Med. - Computational studies on strain transmission from a collagen gel construct to a cell and its internal cytoskeletal filaments. ( 0,799862414495247 )
Med Biol Eng Comput - A new method to include the gravitational forces in a finite element model of the scoliotic spine. ( 0,799618801232647 )
Med Biol Eng Comput - Sensitivity of patient-specific vertebral finite element model from low dose imaging to material properties and loading conditions. ( 0,793287272606526 )
Int J Comput Assist Radiol Surg - Bivariate optimization of orthodontic mini-implant thread height and pitch. ( 0,792596707572622 )
Comput Methods Programs Biomed - Modelling of mandible bone properties in the numerical analysis of oral implant biomechanics. ( 0,792049767542228 )
Comput. Biol. Med. - Biological-data-based finite-element stress analysis of mandibular bone with implant-supported overdenture. ( 0,788661615778005 )
Comput Methods Programs Biomed - Growth plate stress distribution implications during bone development: a simple framework computational approach. ( 0,787687632000633 )
Med Biol Eng Comput - Mechanical and microarchitectural analyses of cancellous bone through experiment and computer simulation. ( 0,778034710542377 )
Med Biol Eng Comput - A three-dimensional finite element model of the cervical spine: an investigation of whiplash injury. ( 0,777478020916811 )
Med Biol Eng Comput - Calibration of the mechanical properties in a finite element model of a lumbar vertebra under dynamic compression up to failure. ( 0,777002870680888 )
Med Biol Eng Comput - Temporal evolution of skeletal regenerated tissue: what can mechanical investigation add to biological? ( 0,776729372823469 )
Med Biol Eng Comput - Sensitivity studies of pediatric material properties on juvenile lumbar spine responses using finite element analysis. ( 0,776297094372777 )
Int J Comput Assist Radiol Surg - Surgical stent planning: simulation parameter study for models based on DICOM standards. ( 0,770116788679156 )
Med Biol Eng Comput - Biomechanical analysis of traumatic mesenteric avulsion. ( 0,769350620405525 )
Med Biol Eng Comput - Effects of skin wrinkles, age and wetness on mechanical loads in the stratum corneum as related to skin lesions. ( 0,768511805134114 )
Comput Methods Programs Biomed - Determination of nonlinear fibre-reinforced biphasic poroviscoelastic constitutive parameters of articular cartilage using stress relaxation indentation testing and an optimizing finite element analysis. ( 0,768409596639517 )
Med Biol Eng Comput - Modeling and experimental methods to predict oxygen distribution in bone defects following cell transplantation. ( 0,767037900700454 )
Med Biol Eng Comput - Validation efforts and flexibilities of an eight-year-old human juvenile lumbar spine using a three-dimensional finite element model. ( 0,765141854330506 )
Med Biol Eng Comput - Change of mechanical vertebrae properties due to progressive osteoporosis: combined biomechanical and finite-element analysis within a rat model. ( 0,763222837122969 )
Comput Methods Programs Biomed - A phenomenological mathematical model of the articular cartilage damage. ( 0,762047295383961 )
Comput Math Methods Med - A review of the combination of experimental measurements and fibril-reinforced modeling for investigation of articular cartilage and chondrocyte response to loading. ( 0,758324145803549 )
Comput Methods Programs Biomed - Experiment and hydro-mechanical coupling simulation study on the human periodontal ligament. ( 0,758080645810431 )
Comput Methods Programs Biomed - Subject-specific finite element simulation of the human femur considering inhomogeneous material properties: a straightforward method and convergence study. ( 0,755840024291258 )
Med Biol Eng Comput - Biomechanical characterisation of fresh and cadaverous human small intestine: applications for abdominal trauma. ( 0,755592049273991 )
Med Biol Eng Comput - Continuous flow left ventricular pump support and its effect on regional left ventricular wall stress: finite element analysis study. ( 0,753876423566007 )
Comput. Biol. Med. - Protein transport in the connecting cilium of a photoreceptor cell: modeling the effects of bidirectional protein transitions between the diffusion-driven and motor-driven kinetic states. ( 0,753616273010165 )
Comput Math Methods Med - Contribution to the determination of in vivo mechanical characteristics of human skin by indentation test. ( 0,750432594392706 )
Comput Math Methods Med - Quantitative imaging of young's modulus of soft tissues from ultrasound water jet indentation: a finite element study. ( 0,747829990184196 )
Med Biol Eng Comput - A quasi-brittle continuum damage finite element model of the human proximal femur based on element deletion. ( 0,747544300493508 )
Med Biol Eng Comput - Can common adhesion molecules and microtopography affect cellular elasticity? A combined atomic force microscopy and optical study. ( 0,747525230242596 )
Med Biol Eng Comput - Strain rate-dependent viscohyperelastic constitutive modeling of bovine liver tissue. ( 0,744338743674016 )
J Med Syst - Post-operative assessment of an implant fixation in anterior cruciate ligament reconstructive surgery. ( 0,743945797854401 )
Comput. Biol. Med. - Prediction of stress shielding around an orthopedic screw: using stress and strain energy density as mechanical stimuli. ( 0,743283550209741 )
Comput Math Methods Med - Comparative evaluation of osseointegrated dental implants based on platform-switching concept: influence of diameter, length, thread shape, and in-bone positioning depth on stress-based performance. ( 0,742520730271547 )
Comput Math Methods Med - Study of tumor growth under hyperthermia condition. ( 0,741586321471954 )
Comput Math Methods Med - Recent advances in computational mechanics of the human knee joint. ( 0,741489864424875 )
Med Biol Eng Comput - 3D finite element analysis on esthetic indirect dental restorations under thermal and mechanical loading. ( 0,741189087987732 )
Med Biol Eng Comput - Modeling and analysis of coagulated liver tissue and its interaction with a scalpel blade. ( 0,74097990949867 )
Comput Math Methods Med - A finite element study of micropipette aspiration of single cells: effect of compressibility. ( 0,74008970869375 )
Comput Math Methods Med - Modeling the relationship between fluorodeoxyglucose uptake and tumor radioresistance as a function of the tumor microenvironment. ( 0,738861473256172 )
Neural Comput - Ambient GABA responsible for age-related changes in multistable perception. ( 0,73830126607918 )
Med Biol Eng Comput - Clinically oriented real-time monitoring of the individual's risk for deep tissue injury. ( 0,73786990572318 )
Comput. Biol. Med. - Tooth fracture risk analysis based on a new finite element dental structure models using micro-CT data. ( 0,737383141871291 )
Med Biol Eng Comput - Biomechanical modeling of brace treatment of scoliosis: effects of gravitational loads. ( 0,736946177626161 )
Med Biol Eng Comput - Estimation of flexible needle deflection in layered soft tissues with different elastic moduli. ( 0,735464250196148 )
Int J Comput Assist Radiol Surg - Quasi-linear viscoelastic modeling of arterial wall for surgical simulation. ( 0,735421500968259 )
Med Biol Eng Comput - The remodeling of alveolar bone supporting the mandibular first molar with different levels of periodontal attachment. ( 0,735162778503709 )
Comput. Biol. Med. - Biomechanical simulation of various surface roughnesses and geometric designs on an immediately loaded dental implant. ( 0,734289588730658 )
Comput. Biol. Med. - Volume conductor models in surface electromyography: applications to signal interpretation and algorithm test. ( 0,731866417335241 )
Med Biol Eng Comput - Finite element analysis of the influence of loading rate on a model of the full lumbar spine under dynamic loading conditions. ( 0,731477524895867 )
Med Biol Eng Comput - Finite element modeling of mitral leaflet tissue using a layered shell approximation. ( 0,731063642859204 )
Med Biol Eng Comput - Mathematical modeling of stem cell proliferation. ( 0,731059293087766 )
Comput. Biol. Med. - Estimation of the reliability of all-ceramic crowns using finite element models and the stress-strength interference theory. ( 0,731033742664846 )
Wiley Interdiscip Rev Syst Biol Med - Ischemic kidney injury and mechanisms of tissue repair. ( 0,730608840859401 )
Med Biol Eng Comput - Finite element analysis of idealised unit cell cancellous structure based on morphological indices of cancellous bone. ( 0,730352174857566 )
Comput. Biol. Med. - Mathematical model of the coagulation in the bone-dental implant interface. ( 0,729952167239256 )
Med Biol Eng Comput - Effects of simulated injury on the anteroinferior glenohumeral capsule. ( 0,729881133452306 )
Med Biol Eng Comput - Backflow length predictions during flow-controlled infusions using a nonlinear biphasic finite element model. ( 0,729666294980859 )
Comput Methods Programs Biomed - Computational analysis of cartilage implants based on an interpenetrated polymer network for tissue repairing. ( 0,729288932997129 )
Int J Comput Assist Radiol Surg - Multi-scale model for investigating the electrical properties and mechanical properties of liver tissue undergoing ablation. ( 0,728287465202951 )
Med Biol Eng Comput - Effect of heterogeneities in the cellular microstructure on propagation of the cardiac action potential. ( 0,728215828250307 )
Comput Math Methods Med - Fluid structural analysis of human cerebral aneurysm using their own wall mechanical properties. ( 0,726792167156041 )
Comput Methods Programs Biomed - Monte Carlo method for photon heating using temperature-dependent optical properties. ( 0,726674657975852 )
Med Biol Eng Comput - A nonlinear finite element simulation of balloon expandable stent for assessment of plaque vulnerability inside a stenotic artery. ( 0,726420662276502 )
Int J Comput Assist Radiol Surg - Reality based modeling and simulation of gallbladder shape deformation using variational methods. ( 0,725186252284551 )
Comput. Biol. Med. - Dynamic finite element analysis and moving particle simulation of human enamel on a microscale. ( 0,72379643747331 )
Comput. Biol. Med. - Modeling of tumor growth undergoing virotherapy. ( 0,723498850216541 )
Comput Math Methods Med - Superficial collagen fibril modulus and pericellular fixed charge density modulate chondrocyte volumetric behaviour in early osteoarthritis. ( 0,723486899467189 )
Comput. Biol. Med. - Design, analysis and verification of a knee joint oncological prosthesis finite element model. ( 0,722354959156613 )
Comput. Biol. Med. - Finite element modelling of diseased carotid bifurcations generated from in vivo computerised tomographic angiography. ( 0,721447094649253 )
IEEE Trans Vis Comput Graph - A Hexahedral Multigrid Approach for Simulating Cuts in Deformable Objects. ( 0,721415898389661 )
Comput. Biol. Med. - Application of an anatomically-detailed finite element thorax model to investigate pediatric cardiopulmonary resuscitation techniques on hard bed. ( 0,717910196590922 )
Med Biol Eng Comput - Development of a subject-specific model to predict the forces in the knee ligaments at high flexion angles. ( 0,714811073556848 )
Comput Math Methods Med - The influence of the specimen shape and loading conditions on the parameter identification of a viscoelastic brain model. ( 0,714443705702245 )
Comput Methods Programs Biomed - A patient specific electro-mechanical model of the heart. ( 0,714222157641914 )
Med Biol Eng Comput - Biomechanical comparison of fusionless growth modulation corrective techniques in pediatric scoliosis. ( 0,712489061198861 )
Comput. Biol. Med. - A computational study of the respiratory airflow characteristics in normal and obstructed human airways. ( 0,712067066984739 )
Med Biol Eng Comput - Effect of layer heterogeneity on the biomechanical properties of ascending thoracic aortic aneurysms. ( 0,711924591338159 )
Comput Methods Programs Biomed - HiL simulation in biomechanics: a new approach for testing total joint replacements. ( 0,711373346586819 )
Med Biol Eng Comput - Extracting the parameters of the double-dispersion Cole bioimpedance model from magnitude response measurements. ( 0,708840228031799 )
Med Biol Eng Comput - In-silico modeling of atrial repolarization in normal and atrial fibrillation remodeled state. ( 0,707288349194591 )
J Med Syst - Thermal shock resistance of skin tissue. ( 0,705241791159984 )
J Biomed Inform - Efficient computation of interacting model systems. ( 0,703633550067015 )
Comput Methods Programs Biomed - Growth of the flat bones of the membranous neurocranium: a computational model. ( 0,703564595970773 )
Med Biol Eng Comput - Influence of ischemic core muscle fibers on surface depolarization potentials in superfused cardiac tissue preparations: a simulation study. ( 0,703148964150356 )
Int J Comput Assist Radiol Surg - In-silico oncology: an approximate model of brain tumor mass effect based on directly manipulated free form deformation. ( 0,702050653262203 )
Int J Med Robot - A physics-based algorithm for real-time simulation of electrosurgery procedures in minimally invasive surgery. ( 0,700344217417847 )
Med Biol Eng Comput - Modeling of the dielectric properties of trabecular bone samples at microwave frequency. ( 0,700238033590417 )
Med Biol Eng Comput - Parameter estimation of the copernicus decompression model with venous gas emboli in human divers. ( 0,700127616611636 )
Med Biol Eng Comput - Biomechanics of thoracolumbar junction vertebral fractures from various kinematic conditions. ( 0,699339233176677 )
Sci Data - Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies. ( 0,698913095800427 )
Neural Comput - Deficient GABAergic gliotransmission may cause broader sensory tuning in schizophrenia. ( 0,697597728898737 )
Int J Comput Assist Radiol Surg - Real-time simulation of the nonlinear visco-elastic deformations of soft tissues. ( 0,696136691225238 )
Med Biol Eng Comput - Estimation of the retainer height biomechanical contribution in posterior resin-bonded fixed partial dentures: a structural-thermal coupled finite element analysis. ( 0,695822604716478 )
BMC Med Inform Decis Mak - Temporal aggregation impacts on epidemiological simulations employing microcontact data. ( 0,695332112395834 )
J. Comput. Biol. - Cytopede: a three-dimensional tool for modeling cell motility on a flat surface. ( 0,694920551476442 )
Comput Methods Programs Biomed - 3D reconstruction of TMJ after resection of the cyst and the stress-strain analyses. ( 0,692633179500581 )