Comput Methods Programs Biomed - Growth of the flat bones of the membranous neurocranium: a computational model.

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Resumo

This article assumes two stages in the formation of the bones in the calvaria, the first one takes into account the formation of the primary centers of ossification. This step counts on the differentiation from mesenchymal cells into osteoblasts. A molecular mechanism is used based on a system of reaction-diffusion between two antagonistic molecules, which are BMP2 and Noggin. To this effect we used equations whose behavior allows finding Turing patterns that determine the location of the primary centers. In the second step of the model we used a molecule that is expressed by osteoblasts, called Dxl5 and that is expressed from the osteoblasts of each flat bone. This molecule allows bone growth through its borders through cell differentiation adjacent to each bone of the skull. The model has been implemented numerically using the finite element method. The results allow us to observe a good approximation of the formation of flat bones of the membranous skull as well as the formation of fontanelles and sutures.

Resumo Limpo

articl assum two stage format bone calvaria first one take account format primari center ossif step count differenti mesenchym cell osteoblast molecular mechan use base system reactiondiffus two antagonist molecul bmp noggin effect use equat whose behavior allow find ture pattern determin locat primari center second step model use molecul express osteoblast call dxl express osteoblast flat bone molecul allow bone growth border cell differenti adjac bone skull model implement numer use finit element method result allow us observ good approxim format flat bone membran skull well format fontanell sutur

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