Comput Methods Programs Biomed - MATLAB-implemented estimation procedure for model-based assessment of hepatic insulin degradation from standard intravenous glucose tolerance test data.

Tópicos

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Resumo

Present study provides a novel MATLAB-based parameter estimation procedure for individual assessment of hepatic insulin degradation (HID) process from standard frequently-sampled intravenous glucose tolerance test (FSIGTT) data. Direct access to the source code, offered by MATLAB, enabled us to design an optimization procedure based on the alternating use of Gauss-Newton's and Levenberg-Marquardt's algorithms, which assures the full convergence of the process and the containment of computational time. Reliability was tested by direct comparison with the application, in eighteen non-diabetic subjects, of well-known kinetic analysis software package SAAM II, and by application on different data. Agreement between MATLAB and SAAM II was warranted by intraclass correlation coefficients =0.73; no significant differences between corresponding mean parameter estimates and prediction of HID rate; and consistent residual analysis. Moreover, MATLAB optimization procedure resulted in a significant 51% reduction of CV% for the worst-estimated parameter by SAAM II and in maintaining all model-parameter CV% <20%. In conclusion, our MATLAB-based procedure was suggested as a suitable tool for the individual assessment of HID process.

Resumo Limpo

present studi provid novel matlabbas paramet estim procedur individu assess hepat insulin degrad hid process standard frequentlysampl intraven glucos toler test fsigtt data direct access sourc code offer matlab enabl us design optim procedur base altern use gaussnewton levenbergmarquardt algorithm assur full converg process contain comput time reliabl test direct comparison applic eighteen nondiabet subject wellknown kinet analysi softwar packag saam ii applic differ data agreement matlab saam ii warrant intraclass correl coeffici signific differ correspond mean paramet estim predict hid rate consist residu analysi moreov matlab optim procedur result signific reduct cv worstestim paramet saam ii maintain modelparamet cv conclus matlabbas procedur suggest suitabl tool individu assess hid process

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