Comput Methods Programs Biomed - Optimal dosing of cancer chemotherapy using model predictive control and moving horizon state/parameter estimation.

Tópicos

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{ treatment(1704) effect(941) patient(846) }
{ state(1844) use(1261) util(961) }
{ model(2656) set(1616) predict(1553) }
{ system(1050) medic(1026) inform(1018) }
{ cancer(2502) breast(956) screen(824) }
{ imag(1057) registr(996) error(939) }
{ howev(809) still(633) remain(590) }
{ perform(999) metric(946) measur(919) }
{ import(1318) role(1303) understand(862) }
{ visual(1396) interact(850) tool(830) }
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Resumo

Model predictive control (MPC), originally developed in the community of industrial process control, is a potentially effective approach to optimal scheduling of cancer therapy. The basis of MPC is usually a state-space model (a system of ordinary differential equations), whereby existing studies usually assume that the entire states can be directly measured. This paper aims to demonstrate that when the system states are not fully measurable, in conjunction with model parameter discrepancy, MPC is still a useful method for cancer treatment. This aim is achieved through the application of moving horizon estimation (MHE), an optimisation-based method to jointly estimate the system states and parameters. The effectiveness of the MPC-MHE scheme is illustrated through scheduling the dose of tamoxifen for simulated tumour-bearing patients, and the impact of estimation horizon and magnitude of parameter discrepancy is also investigated.

Resumo Limpo

model predict control mpc origin develop communiti industri process control potenti effect approach optim schedul cancer therapi basi mpc usual statespac model system ordinari differenti equat wherebi exist studi usual assum entir state can direct measur paper aim demonstr system state fulli measur conjunct model paramet discrep mpc still use method cancer treatment aim achiev applic move horizon estim mhe optimisationbas method joint estim system state paramet effect mpcmhe scheme illustr schedul dose tamoxifen simul tumourbear patient impact estim horizon magnitud paramet discrep also investig

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